Protein Alignment puf and usp25

DIOPT Version :10

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: XP_009303832.2
• Gene: usp25 / 406790
• ZFINID: ZDB-GENE-040426-2847
• Length: 1166
• Species: Danio rerio
• Alignment Length: 1064
• Identity: 206/1064 - (19%)
• Similarity: 359/1064 - (33%)
• Gaps: 370/1064 - (34%)

  Fly  1987 LAQHKSGPKQPYPWDYW-----PRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRV 2046
            :|::|:..|:.:. :.|     |.:..|.|...|||.|:|.||:.::.:|.|:.:.:.:..||..
Zfish   136 IAENKASLKRTHT-EVWSDSPNPHERKRMENCPVGLKNVGNTCWFSAVIQSLFNLLEFQRLVLHY 199

  Fly  2047 PPNA--------ARKHG--PTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMA 2101
            .|.|        .::|.  |.:.||:.:|:.|:.|:||..:|.....:.: |....:..:|:|::
Zfish   200 SPPARMQDLPRNQKEHRNLPFMQELRHLFSLLVGSKRKYVDPSGAVEILK-DAFKSSESQQQDVS 263

  Fly  2102 EFFIDLVSKLEDM------------TPDLKHLVKRLFCGS-LSNNVVSLDCGHVSRTAEDFYTVR 2153
            ||...|:..|||.            .|  |:.:..||.|. |:..|:.   |......|.|....
Zfish   264 EFTHKLLDWLEDAFQIKAEEDREGEKP--KNPMVELFYGRFLAVGVLE---GKKFENTEMFGQYP 323

  Fly  2154 CQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVT 2218
            .||...::|.|.|:...::..:|  ::::.....|   :.:...|.:||.:|.|...|:.||...
Zfish   324 LQVNGFKDLHECLEAAMIEGEIE--SLHSAENSAK---SGQEHWFTELPPVLTFELSRFEFNQAL 383

  Fly  2219 MLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEK----------------------- 2260
            ...||::....||..|.|..|:::.....:.|.|..||.||.
Zfish   384 GRPEKIHNKLEFPSMLYMDRYMDRNREITRIKREEIRRLKEHLTVLQQRLERYLSYGSGPKRFPL 448

  Fly  2261 --------------------------------------------------EGADGSGDG------ 2269
                                                              ..|:|||.|
Zfish   449 ADVLQYAMEFASSKPVCTSPVEDIDTTAPPGGTIAQLPPPASAGEQPDACVSAEGSGSGLQASQQ 513

  Fly  2270 -------------------------------------------------NDNEKAEATLD---DD 2282
                                                             ||....:|::.   ..
Zfish   514 QQQRVSIHKPFTQSRVPPDLPMHPAPRHITEEELRVLESCLHRWRSEVENDTRDLQASISRIHRT 578

  Fly  2283 IEECYE--------YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQ 2339
            ||..|.        |.|..|.||.|.|:.|||:::|.:|     | |:||..:||..|......:
Zfish   579 IELMYSDKSMMQVPYRLHAVLVHEGQANAGHYWAYIYDR-----H-HQRWMKYNDIAVTKSSWEE 637

  Fly  2340 IAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEE 2404
            :..:.|||                   .:..|||.|.|                 .....|.:.:
Zfish   638 LVRDSFGG-------------------YRNASAYCLMY-----------------IDDKKPFLIQ 666

  Fly  2405 KSEAEEPTKMETSSSEIKADVDVEVEVEEK-----------------DKEKPA------------ 2440
            :...:|..:|.:...::..|:.|.||.:.|                 .:||.|
Zfish   667 EEFDKETGQMLSGLDKLPPDLKVFVEADNKLFEREMEEWDALQARKLQQEKLALAAAAAAAAAAS 731

  Fly  2441 -QTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEKPTEMTTVSTE-EEKQPTA 2503
             .....|.|..:.:..|...:.|.:||  .:|:||..|:.|...::....::..:.| :||.|.|
Zfish   732 VAVQPMSTEPCSPDNTAPSAAPQHDPE--YMEQQSPSGDSKHLQEDTERAISKAAAEHDEKSPEA 794

  Fly  2504 NCDNHQQNNNSNSKASNDQQPS------------------TSKAAQKLQLFRPLLNKE---LEDW 2547
            .. |..|:::.:||.::|..|.                  ...|...:..| .:.:||   .::.
Zfish   795 LL-NTSQSSHPDSKLTSDPCPPPDPEQDDPTCPPPGPQRVVEVAIPNVGTF-VIQSKEGGYDDEA 857

  Fly  2548 IWQDNRQFL-----QDRNIFEHTYFNFMWQICGHIPQSL------ISETDVTCMAAK-------L 2594
            :...|.|.:     :.|::::.         ||  |::.      :..|.:..:|.:       .
Zfish   858 MMTPNMQGIIMAIGKSRSVYDK---------CG--PEAAFFKAMKVEYTRLLRLAQEDTPPERDY 911

  Fly  2595 SVSFFIETFIHAKEKPTMVPWVE-LLTKQFN----ASQEACEWFLS--------------HMSQE 2640
            .:...|..||| .|.|..:  || .|..||.    ...|.|:..:.              :|.:.
Zfish   912 RLQHVIVFFIH-NEAPKKI--VERTLLMQFADRNLGFDERCKSIMKVARAKLELIKPDEVNMEEY 973

  Fly  2641 PYW----------PVQVLIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQA 2695
            ..|          .|.:||.. ...:::.|...::::|      :|:.|        :|||:.:.
Zfish   974 EMWHQDYRIFRETSVFLLIGL-ELFMKKSFVEALMYLI------YAYQY--------NKELLAKG 1023

  Fly  2696 SCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQT 2760
            .    :.|....|:.|..|..|..|:||...|.|..    |||.....:.::..||...|.....
Zfish  1024 P----YRGHDEELIAHYRRECLLKLNEYAAALFETG----EEAKVNTGLSIMNDLVVPCLPLLLV 1080

  Fly  2761 DSIDISSDNEDNSSEEALSVEKMR 2784
            |.::         .::.::||.||
Zfish  1081 DEME---------EKDMVAVEDMR 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/530 (20%)
		DUF3517	2648..>2884	CDD:463438	30/137 (22%)
		MDN1	<3661..>3887	CDD:444083
usp25	XP_009303832.2	None