DRSC/TRiP Functional Genomics Resources

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Protein Alignment puf and Usp7

DIOPT Version :9

Sequence 1:NP_001262923.1 Gene:puf / 42935 FlyBaseID:FBgn0039214 Length:3930 Species:Drosophila melanogaster
Sequence 2:NP_001019961.1 Gene:Usp7 / 360471 RGDID:1306915 Length:1103 Species:Rattus norvegicus


Alignment Length:1044 Identity:210/1044 - (20%)
Similarity:360/1044 - (34%) Gaps:306/1044 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  2000 WDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRM 2064
            ||      .:...|||||.|.||||||.|.:|.|:...|.|.||..:|...........|.|||:
  Rat   206 WD------SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRV 264

  Fly  2065 FAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPD--LKHLVKRLFC 2127
            | |.|:...|....:...:.:  ..:.|::..|.|:.|....|:..:|:....  ::..:.:||.
  Rat   265 F-YELQHSDKPVGTKKLTKSF--GWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFR 326

  Fly  2128 GSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRA 2192
            |.:.:.:...:..:.|...||:|.::..:...:|:.||..:....:.|:|||.|...:.|.: .|
  Rat   327 GKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQ-EA 390

  Fly  2193 EKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQ 2257
            ||...|..||.:|....||:.::..|....|:|..|.||.:|.:..:::||              
  Rat   391 EKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKT-------------- 441

  Fly  2258 KEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHE 2322
                                    |.::...|.|..|.||:|...||||..::..:      ...
  Rat   442 ------------------------DPKDPANYILHAVLVHSGDNHGGHYVVYLNPK------GDG 476

  Fly  2323 RWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQR 2387
            :|..|:|         .:.:.|...|.....|....:   |.|.....:||||.|.|      :.
  Rat   477 KWCKFDD---------DVVSRCTKEEAIEHNYGGHDD---DLSVRHCTNAYMLVYIR------ES 523

  Fly  2388 RHSELLVTPT----PSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKE 2448
            :.||:|...|    |...||   ..:|..::|....:.:.:..:.::|                :
  Rat   524 KLSEVLQAVTDHDIPQQLVE---RLQEEKRIEAQKRKERQEAHLYMQV----------------Q 569

  Fly  2449 TPAKEEIADDKSKQDEPEEK------KIEKQSREGE---EKSETDEKPTEMTTV-----STEEEK 2499
            ..|:::....:......|||      |:.|.|...|   ..|:|...|.:...:     .:...|
  Rat   570 IVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTK 634

  Fly  2500 QPTANCDNHQQNNNSNSKASNDQQPST--------SKAAQKLQLFRPLLNKELEDWIWQDNRQFL 2556
            :| |..||....:.:..:.|:::.|.|        ..||....|  |..:|:             
  Rat   635 RP-AMLDNEADGSKTMIELSDNENPWTIFLETVDPELAASGATL--PKFDKD------------- 683

  Fly  2557 QDRNIFEHTY------FNFMWQICGHIPQSLISETDVTCMAAKL------SVSFFIET--FIHAK 2607
            .|..:|...|      .|:    ||||      .|.::|....|      ...|..:|  .::.:
  Rat   684 HDVMLFLKMYDPKTRSLNY----CGHI------YTPISCKIRDLLPVMCDRAGFIQDTSLILYEE 738

  Fly  2608 EKPTMVPWV------------ELLTKQFNASQE------------ACEWFLSHMSQEPYWPVQVL 2648
            .||.:...:            ||:.......|:            |.|:|     ::.|..|.|:
  Rat   739 VKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYF-----RDLYHRVDVI 798

  Fly  2649 IQC----PN---------------QMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQ 2694
            . |    ||               |:.:.:.|||          :...:.|:....:..::..|.
  Rat   799 F-CDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRL----------NTDPMLLQFFKSQGYRDGPGN 852

  Fly  2695 ASCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQ 2759
            .             |.|.....||.|.::|       :....:.:|..:   ||..:..:...:.
  Rat   853 P-------------LRHNYEGTLRDLLQFF-------KPRQPKKLYYQQ---LKMKITDFENRRS 894

  Fly  2760 TDSIDISSDNEDNSSEEALSVEKMRPASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKG 2824
            ...|.::|    ...||.:::...:...:..::..|...||....|..||||             
  Rat   895 FKCIWLNS----QFREEEITLYPDKHGCVRDLLEECKKAVELGDEASGRLRL------------- 942

  Fly  2825 FPFLYQQIKDGINPHQTKHLIHALC-------RWDERLATQIIGMLFASVTKHTEL---CAPFFK 2879
            ...:..:|   |..||...|:..|.       |.:|....|:      ::.|..|:   .|.|.|
  Rat   943 LEIVSYKI---IGVHQEDELLECLSPATSRTFRIEEIPLDQV------NIDKENEMLITVAHFHK 998

  Fly  2880 LLTLLTETQGGPVGLPCFTQL--------ILPRMWDAAEYCPQSVLDWLSLQATKNKIA------ 2930
            .:.       |..|:|...::        ::.|:        ||:||....:..|.|.|      
  Rat   999 EVF-------GTFGIPFLLRIHQGEHFREVMKRI--------QSLLDIQEKEFEKFKFAIVMMGR 1048

  Fly  2931 HAWI 2934
            |.:|
  Rat  1049 HQYI 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pufNP_001262923.1 peptidase_C19C 2013..2382 CDD:239124 93/370 (25%)
UCH 2014..2377 CDD:278850 90/364 (25%)
DUF3517 2723..>2877 CDD:288853 28/163 (17%)
Usp7NP_001019961.1 Interaction with TSPYL5. /evidence=ECO:0000250|UniProtKB:Q93009 1..209 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Interaction with p53/TP53 and MDM2. /evidence=ECO:0000250|UniProtKB:Q93009 54..209 2/8 (25%)
COG5077 56..1101 CDD:227409 210/1044 (20%)
MATH_HAUSP 68..203 CDD:239741
Necessary for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q93009 71..206 210/1044 (20%)
peptidase_C19C 213..524 CDD:239124 93/376 (25%)
USP7_ICP0_bdg 621..866 CDD:289221 50/299 (17%)
USP7_C2 876..1087 CDD:291217 42/221 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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