DRSC/TRiP Functional Genomics Resources

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Protein Alignment puf and usp24

DIOPT Version :9

Sequence 1:NP_001262923.1 Gene:puf / 42935 FlyBaseID:FBgn0039214 Length:3930 Species:Drosophila melanogaster
Sequence 2:XP_005170208.1 Gene:usp24 / 325631 ZFINID:ZDB-GENE-030131-4356 Length:2621 Species:Danio rerio


Alignment Length:2931 Identity:621/2931 - (21%)
Similarity:1043/2931 - (35%) Gaps:804/2931 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 STTLTMRLAGMAQINAHINLFNEICTTETVNEVELFGQRIANWLTENHIVQHLFG-----PNLHV 411
            ||.|...  |:|..:.:...|.:.|..|...:: |....:..|.||.|  :.::.     .:|..
Zfish   141 STCLARH--GLADADENCKRFIDRCMPEAFKKL-LTSSAVHKWGTEIH--EGIYNMLMLLVDLVA 200

  Fly   412 EIVKQAHVLLNFLAVENQISEEDIKLIWQATQLKHCSK---------TIFDILPSLVKNLTPRPA 467
            |.|||..:.:..:.|.......|.:..:: .::|.|.:         ::|.:.||  .:....|.
Zfish   201 ERVKQDPIPIGLMGVLTMAFNPDNEYHFK-NRMKACQRNWAEVFGEDSMFAVSPS--SSYQKEPH 262

  Fly   468 MHLYSLL-------------CRMDPKEHTEQSIYIASALTKQLWTRDTSRSQMNLMQDHLLGSNV 519
            ..|..|:             |:::.:   |..|...|||.:.|                    .|
Zfish   263 GWLVDLVNRFGEMGGFTAIQCKLNQE---EIEIGCVSALVQPL--------------------GV 304

  Fly   520 TASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRRHICDPTTEKG 584
            .|...:|..::                                            .:.||...  
Zfish   305 CAEYLNSSLVQ--------------------------------------------PMLDPVIH-- 323

  Fly   585 KQIS-PEDMAKVDLVNKRIVNIIDNTSSEEELQSRAALELQLHRSRKKTSNKRRRQKTNKQIILP 648
            |.|: .:::.:.||.:||:|:|      .|.|.:...|.::..|......:..|.....:.:..|
Zfish   324 KMITYVQNLEEKDLKDKRLVSI------PELLSAIKLLCMRFQRELVNVVDDLRLDILLRMLKTP 382

  Fly   649 H------ELVEIWDGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQLVPDAVLKHLQGEG 707
            |      .|.|:...:|:...|.......|              :|.....||.::||.      
Zfish   383 HFSAKMNSLKEVTKLIEESTVSKTVKNAID--------------TDRLLDWLVENSVLS------ 427

  Fly   708 PFIRAIETNINELLSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCS---- 768
               .|:|.||::        ..|...:     |.:.:.....:|  .:||:::...:|..|    
Zfish   428 ---IALEGNIDQ--------AQYCDRI-----KGIIELLGSKLS--LDELSKIWKIQAGQSSTVI 474

  Fly   769 -DVPPAFAAAAAAMMVAQSA---MALQKSGE----------SNVAAAAAAVAAAAAATGTAQQTL 819
             ::....||||......|.:   :.:|||.|          .::.......|.:.|.||...:.|
Zfish   475 ENIHTIIAAAAVKFNFDQLSHLFVLIQKSWEVESDRVRQKLLSLIGRIGREARSEATTGKVLEVL 539

  Fly   820 ----------VAMNRQA------SVAAAAAVVAAAK----AKSDSDVDLMDVVSGGKQHHSPKAS 864
                      .::.:||      .::.|.||....|    .|...|:..|.:....|   ||..:
Zfish   540 WELAHLPTLPTSLVQQALEEHLTILSDAYAVKETIKRNYIIKCIEDIKKMQIQEDSK---SPSET 601

  Fly   865 QGSSTSGSTPVQPSFKLNDVCQPGNTLLWDLLQDDKIGQLGESLALEAEKALATLLCFSMDRQLR 929
            |.|..:|:                    |                  .:|..::|...|.....:
Zfish   602 QVSFLTGT--------------------W------------------GKKKPSSLAKSSQQTNPQ 628

  Fly   930 TKFIEGCLYNVANNRSVIVSLRLLPKLFASF--QQFRPSDTHSMTMWAERNHRMMQCFFNNIRHY 992
            |.:             |:.:||.|.::..||  |.::..| .|:....::|..:::....::.. 
Zfish   629 TVW-------------VVPALRQLHEITRSFIKQTYQKQD-KSIIQDLKKNFEIVKLITGSLVS- 678

  Fly   993 ARRHAEVLITQNGEQQQQQLGGQLYSHKTQVSVRLQFLSSIFSTVGSPKSFRLTLEQLDALWEWL 1057
            ..|.|..:...||......:.|: ||::..:...|:||:......    |..|...:...:||.|
Zfish   679 CHRLAVSVAGSNGLSGSTLVDGR-YSYQEYLEGHLKFLAFFLQEA----SLYLVWNRAKEIWECL 738

  Fly  1058 AHDPECAD-----CYFSWLQAQAKGGDQHALGIEALQHLYLKKLPELRPEEFSMVALGLFQQLCS 1117
            ....:..:     | |.|.   .||  ||.|..:..|.|:.:|:.:|.|.|.:|....||:....
Zfish   739 VSGMDVCELDREMC-FEWF---TKG--QHDLESDVQQQLFKEKILKLEPYEITMNGFNLFKTFFE 797

  Fly  1118 FARIAMAEYDNHSDQISAS-ASAVGMYHLWKIALRAQSNDVSLAAIQYINMY-YMG-------QQ 1173
            ...::.........|:... ....||..:|:||:.:...|::..|||.|..| |:.       ..
Zfish   798 NVNLSDHRLKRQGTQLCVERLDLAGMDFIWRIAMESPDEDIANEAIQLIITYSYINLNPKMKKDS 862

  Fly  1174 LRLEKEFVSQCMENLVQA----------------------------ATALESIDDENALMRVQRG 1210
            :.|.|:|::.|.:.|..|                            ||:::|....:.|:.::|.
Zfish   863 VSLHKKFIADCYKRLEAASSALGGPTLTHAVTRATKMLTATAMPTVATSVQSPSRSSKLVIIERL 927

  Fly  1211 LLLLNTHLDTFRRRYAFHLRRWAIEGKGIGSHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACD 1275
            |||...::.|....|:...   .|...|...|        |.|:.:.:......:...|:.|:.:
Zfish   928 LLLAERYVITIEDLYSVPR---TILPHGASFH--------GHPVTLHITYESTKDTFTLEAHSNE 981

  Fly  1276 LIADLKAEVSKWWESLQTGLAAPVLGLLLSDGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYV 1340
            .|..::      |: :...|:.||       ..::|......||.:.|::.|...||.|.|.:.|
Zfish   982 TIGSIR------WK-IADQLSCPV-------DNVQIFANDSMLTMNRDQKLLNQLGFSDEQSLTV 1032

  Fly  1341 SLGGRG----------ARRKESN---------LEHPSMLPPPPKECLPTVLLLQPKYFEKLFCLM 1386
            ...|.|          |....|:         ||....||       ..|:.|....||.|:.| 
Zfish  1033 KSSGTGTPSGSSADSSASASSSSSGVFNSAYALEQEKSLP-------GVVMALVCNVFEMLYQL- 1089

  Fly  1387 QTLGDMQPQASTVNPQHHTKAQLLSRRVWDILAMLPTNPHILDAFKSLVTDLSE-------LEQL 1444
                     |:...|:       ::.||..:|.::||:|.:.||..:.|...|.       |..|
Zfish  1090 ---------ANLEEPR-------ITLRVRKLLLLIPTDPEVQDALDNFVPKESSVWSHQKTLFTL 1138

  Fly  1445 DAGGEEEQLATKRKQIKQKFRDLLDPNNLQKFMYSLHIVESLALTSSRRGESNGNVAMGNTPEQV 1509
            .:|.:    |:|...:..|         .|....:..|:||| ..||..|.|...|..     .:
Zfish  1139 GSGSQ----ASKSPSLSSK---------QQHQQSAASILESL-FRSSAPGMSTFRVLY-----NL 1184

  Fly  1510 RVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCE--LEAPLTPTPSTGLQ---DVETEASSSSGGD 1569
            .|..|.:        .|.......|.|.:..||  |:|       .||.   :|....|..|..|
Zfish  1185 EVLSSKL--------MPTSDDEMAKTSVKSFCENFLKA-------GGLSLVVNVMQRDSIPSEVD 1234

  Fly  1570 KENQ--------------------PKQHSKRQKKGETFEQEKERPVG---------CSTPPSPTP 1605
            .|.:                    |....:...|.:|......|..|         |.||...: 
Zfish  1235 YETRQGVYSICLQLARFLLVGQAMPSILDEELSKDDTLSSRPFRNAGRQSGRQLSVCGTPEKSS- 1298

  Fly  1606 PPPALSVVERGDNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKELALNEWRHDCLASLLRILWL 1670
             ...:||.:|...:..|..   ...|...:....|....:               :|..:|:.|.
Zfish  1299 -YRQVSVSDRSSIRVEEII---PAARVAIQTMEVGDFTST---------------VACFMRLTWA 1344

  Fly  1671 LGFEELQSADAHVLMSRPHPFMLQLMEVPQCL------TRLSSILNDEVHQQHQASSANPLVFPY 1729
            .....|.      |:....|    :.|....|      :|:||.      ..:.:||:...|...
Zfish  1345 AAAGRLD------LVGSSQP----IRETTNSLLPLGVRSRVSST------GSNCSSSSEGEVTTL 1393

  Fly  1730 Q--------FQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLWAPTGTDHCRWLQKFILEDP 1786
            |        |..::.....|.     |:::||:.:...::.....::....:.  ::...:|..|
Zfish  1394 QAGICVKQLFVSIKDTIIARE-----ALSLLVTCLQLRSQQLCSFYSLLSVND--FIIDILLGSP 1451

  Fly  1787 EPAVRREICAGLYRICLGNAHSYRLLLAPLLH----KLIALLPLAEQMSSGNQHTQFLLSEEGKD 1847
            ...:||..|..||.:...:..:|..|..|.|.    .|.|.|||....|......|.|||:    
Zfish  1452 SGEIRRVACDQLYTLSQSDTSAYPDLQKPNLFLLKVVLTAQLPLWSPTSIMRGVNQRLLSQ---- 1512

  Fly  1848 PYGPACRDYFWLLARLVDTLSPEMVAEEHI-DIEMLCESIS-----QSILTREYYELRHGYQDDG 1906
                 |.:||.|..:|:|.|:...:.:..| ...||.:.||     :...|.   ||.....|:.
Zfish  1513 -----CTEYFDLRCQLLDDLTTSEMEQLQIGPAAMLEDEISWLDNFEPTWTT---ELETSEADNI 1569

  Fly  1907 LV-GLLNLMSNLIKYDTTFK--YTPKALSFIEQLI-GFLF---------DMPSPADRQ----KPK 1954
            |: |.|.|:..|:....|.|  :.|   |.|:||: .|||         |..|.....    .||
Zfish  1570 LLAGHLRLIKTLLSLCGTEKEQFGP---SLIQQLLDDFLFRASRIILNSDSSSSTTASIHDFHPK 1631

  Fly  1955 CKSASSRASAYDLLVELCRGCATNYAYLHGRLLA-QHKSGPKQPYPWDYWPRDEGRAECGYVGLT 2018
            |.:.|||.:||::||.|.....||...:...||: .|:|.|.....:||.|..:.|:..|:|||.
Zfish  1632 CSTVSSRLAAYEVLVMLADSSLTNLQLITKELLSMHHQSDPSLSKEFDYLPPVDSRSISGFVGLK 1696

  Fly  2019 NLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSFCR 2083
            |.||||||.:..|.|||.|.....||.:..:..........::|.:|.:|:||:.:.|.|.:|.:
Zfish  1697 NGGATCYMNAVFQQLYMQPGLPEGVLSIEDDTENPEESVFCQVQSLFGHLMESKLQYYVPENFWK 1761

  Fly  2084 VYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDL--KHLVKRLFCGSLSNNVVSLDCGHVSRTA 2146
            :::|.::.|...||:|..|||..||.:|::....:  :.:.|..|.|..|:..:..||.|.....
Zfish  1762 IFKMWNKELYVREQQDAYEFFTSLVDQLDEHLKKIGREQIFKNTFQGIFSDQKICKDCPHRYERE 1826

  Fly  2147 EDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMR 2211
            |.|..:...|...::|:.|||:....:.|:|.|.|.|.:|.:|....||.|.|.||.:|..:.||
Zfish  1827 ETFMALNLGVTSCQSLEISLDQFVRGEVLDGSNAYYCEKCKEKRTTVKRTCIKSLPSVLVIHLMR 1891

  Fly  2212 YTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAE 2276
            :.|:..:....|.:....||..|||..|....:..|.  ...:..:..:.|..||| |:..:|  
Zfish  1892 FGFDWESGRSIKYDEQIRFPWVLNMEPYTVSGMARQD--SSADHGENGRGGEAGSG-GSPRKK-- 1951

  Fly  2277 ATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQ-- 2339
            .|:.::      ||||||.||:|.|..||||||||:|..::   ..||:.|||..|:.||.:.  
Zfish  1952 VTISEN------YELVGVVVHSGQAHAGHYYSFIKDRRGSA---RGRWYKFNDNVVEEFDMNDET 2007

  Fly  2340 IAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEE 2404
            :..||||||...|.||. :..|.|......| ||||||:|              ::...||.:.:
Zfish  2008 LEYECFGGEYRPKVYDQ-SNPYPDVRRRYWN-AYMLFYQR--------------ISDQNSPVLPK 2056

  Fly  2405 KS-------EAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQ 2462
            ||       |||:.:....||.||                                      |.|
Zfish  2057 KSRVSIMRQEAEDLSLSAPSSPEI--------------------------------------SPQ 2083

  Fly  2463 DEPEEKKIEKQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTS 2527
            ..|                                 :.|.||               ||:....:
Zfish  2084 SSP---------------------------------RPPRAN---------------NDRLTLLT 2100

  Fly  2528 ---KAAQKLQLFRPLLNKELEDWIWQDNRQFLQDRNIFEHTYFNFMWQICG-------HIPQSLI 2582
               |..:|..||...:...:...:..:|.:|:::|:::...||:|...:..       |.....:
Zfish  2101 RLVKKGEKKGLFVEKMPARIFQMVRDENLKFMKNRDVYNSDYFSFTLSLASVNATKLKHASYQAM 2165

  Fly  2583 SETDVTCMAAKLSVSFFIETFIHAKEKPTM--VPWVELLTKQFNASQEACEWFLSHM-SQEPYWP 2644
            ::|.:     :|:|.|.:.|::..|:|..:  ..|:..:....:.|.|||:|.:.:: :.|....
Zfish  2166 AKTSL-----QLAVQFLLHTYLRTKKKLRVDTEEWIATVEVLLSKSSEACQWMVQYLVAPEGREI 2225

  Fly  2645 VQV-LIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIGSLISL 2708
            ::: |::|   .||::  |:|:..|.:.....|..:.:...|           |:   :..|:||
Zfish  2226 IKICLLEC---SVREV--RVVVATILEKTLESALYFQDAGLD-----------CL---LDMLLSL 2271

  Fly  2709 LEHGARANLRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDNS 2773
            |:.....|.::.|:||.|...|::.|......||:....:.::.|.||           .|..|:
Zfish  2272 LDKDVPDNCKNCSQYFSLFSNFAQRGCGPCQLLLKHSAYRRMLVFLLG-----------PNRQNN 2325

  Fly  2774 SEEALSVEKMRP-ASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDG-I 2836
            .....|..:.|. ..|...:||.....:.:              |.....:|   :::|...| :
Zfish  2326 QHRRWSSAQAREFLHLHNTLALMVLHTDLT--------------SQRTEAQG---VFKQASSGLV 2373

  Fly  2837 NPHQTKHLIH-----ALCRWDERLATQIIGMLFASVTKHTELCAPFFKLLTLLTETQGGPVGLPC 2896
            .|......:|     .|.:.|.:  ..::.::||.    .||..|...|:.::|           
Zfish  2374 APSSVLMPLHPDINTLLFKADGQ--AYLMEVMFAM----RELSGPLSFLIEMIT----------- 2421

  Fly  2897 FTQLILPRMWDAAEYCPQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFL 2961
                       .:.:|              |:.....:||..:..||. ...|:   ::|....|
Zfish  2422 -----------YSSFC--------------NEPFSLGVLQLLKNHLET-APPHE---LKNVFQML 2457

  Fly  2962 LVALV---PSQPFRANFRAHSQHKLLALNPHSYRDINSDAQAVLHQVITLLLRLLR---PARVY- 3019
            |..|:   |.|..|..|...|:..|||| .|...:::|..   .:|.:..|:.|.:   ||:.| 
Zfish  2458 LEILMLEDPLQSQRLKFAFESEKGLLAL-MHQSNNVDSSR---CYQCVKFLVTLAQKCSPAKDYF 2518

  Fly  3020 ADIGAH 3025
            .::..|
Zfish  2519 KELSGH 2524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pufNP_001262923.1 peptidase_C19C 2013..2382 CDD:239124 129/372 (35%)
UCH 2014..2377 CDD:278850 125/366 (34%)
DUF3517 2723..>2877 CDD:288853 29/160 (18%)
usp24XP_005170208.1 UBA_UBP24 7..43 CDD:270472
peptidase_C19C 1691..2048 CDD:239124 129/386 (33%)
UCH 1693..2043 CDD:278850 125/365 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D625455at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
32.870

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