DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and Usp30

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	NP_001284912.1	Gene:	Usp30 / 31519	FlyBaseID:	FBgn0029819	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	147/701 - (20%)
Similarity:	220/701 - (31%)	Gaps:	241/701 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1765 LLWAPTGTDHCRWLQKFILEDPEPAVRREICAGLYRI---CLGNAHSYRLLLAPLLHKLIALLPL 1826
            :.|.|:|:   |..|           ||...|||:..   |..|.....:...|   :.||.|.|
  Fly    22 VFWGPSGS---RLRQ-----------RRGQIAGLHNFGLTCFLNTLLQAMAACP---QFIAWLQL 69

  Fly  1827 AEQMSSGNQH--TQFLLSEE---------GKDPYGPACRDYFWLLARLVDTLSPEMVAEEHIDIE 1880
            ....|...:.  |..|.:.|         ..|||.|..      :.|.::.|...:..|||
  Fly    70 YNNASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGA------VLRALNALGWVIPQEEH---- 124

  Fly  1881 MLCESISQSILTREYYELRHGYQDDGLVGLLNLMSNLIKYDTTFKYTPKALSFIEQLIGFLFD-M 1944
                         :.:||.|       |.|..|....|:               .|.:|.|.| :
  Fly   125 -------------DAHELFH-------VLLTCLEEEAIR---------------PQPLGCLSDAL 154

  Fly  1945 PSPADRQKPKCKSASSRASAYDLLVELCRGCAT------NYAYLHGRLLAQHKSG--PKQP---- 1997
            |:..|       ..||.|           |.||      :::.:...|.|..:.|  |.:|
  Fly   155 PTDND-------DNSSLA-----------GTATPVGGFRSFSSMAAGLGASQRIGDQPNRPSSAM 201

  Fly  1998 ----YPWDYWPRDEG-------RAE----------CGYVGLTNLGATCYMASCVQHLYMMPQARA 2041
                ...:|   ||.       |:|          |...|...||:....|......:..|
  Fly   202 LTDFLNMEY---DESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFP---- 259

  Fly  2042 AVLRVPPNAA-------RKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKD 2099
             ::..|.:.|       |...|.|.:.|:.     :.|..:....|.||..:..|:    |..:
  Fly   260 -LVSNPDSLATPMLGGERSSRPRLPQSQQQ-----QDEGLNRRVSSSCRSLERLHR----GPGR- 313

  Fly  2100 MAEFFIDLVSKLEDMTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAED-FYTVRCQVADMRNLQ 2163
                    ||...:|.|.   .|...|.|::...:|...||..|....| |.::...:...|...
  Fly   314 --------VSIWSNMMPS---QVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLPPQRRTG 367

  Fly  2164 ESL-----DEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVT--MLK 2221
            .||     :.:|.:|..:    ..|..|.:.....|...|.|||..||.:..| |..:.|  :.|
  Fly   368 LSLGHLLSEYITSEDLSD----VKCDSCNETTTHTKSVTFAKLPACLCIHVAR-TVWLPTGQVCK 427

  Fly  2222 EKVNTHFSFPLRLNMCHY--VEKTLMPQQ----------YKEERERRQKEKEGADGSGDGNDNEK 2274
            .|...|  ||..|:|..|  |:..|..|.          |.......       :|.|.|   |.
  Fly   428 RKDYVH--FPESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMN-------NGVGGG---EG 480

  Fly  2275 AEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQ 2339
            .......::     |.|:.|.||:|.|:.||:.::    .:.|.....||:..:|..|:
  Fly   481 FGTMFPKNL-----YRLLAVVVHSGEANSGHFVTY----RRGSLRNAHRWYYTSDTIVR------ 530

  Fly  2340 IAAECFGGEMTSKTYDSVTEKYLDFSFEKTNS--AYMLFYERRLPEHLQRR 2388
                                   :.|.::..|  ||:|||:|.....|..|
  Fly   531 -----------------------EVSIDEVLSVPAYLLFYDRGQQRQLNLR 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	85/397 (21%)
		UCH	2014..2377	CDD:278850	82/391 (21%)
		DUF3517	2723..>2877	CDD:288853
Usp30	NP_001284912.1	Peptidase_C19	39..>139	CDD:271592	29/132 (22%)
		UCH	<304..547	CDD:278850	67/313 (21%)
		Peptidase_C19F	<323..548	CDD:239127	62/282 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010