DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and Usp47

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_006230106.1	Gene:	Usp47 / 308896	RGDID:	1310411	Length:	1395	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	137/554 - (24%)
Similarity:	223/554 - (40%)	Gaps:	122/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2009 RAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLL--ELQRMFAYLLES 2071
            ::|.|||||.|...|||:.|.:|.|:|.|:.|.|:.:.....:.:...|.:  :|||:|..|..|
  Rat   182 KSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTS 246

  Fly  2072 ERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLKH--LVKRLFCGSLSNNV 2134
            ::::.......|.:..|..  ...:|.|:.|....:...||......:.  |:..|:.|.|.:.|
  Rat   247 KKRAIETTDVTRSFGWDSS--EAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYV 309

  Fly  2135 VSLDCGHVSRTAEDFYTVRCQVAD------MRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAE 2193
            ..|:||:.....:.:..:...:..      ..:::|:|......:.|:|.|.|.|.:|.||..|.
  Rat   310 RCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDAR 374

  Fly  2194 KRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQK 2258
            |...|...|.:|.....|:.|:..||.:.|:|...|||..|:|..:::        .|:.:..|.
  Rat   375 KGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFID--------IEDEKSPQT 431

  Fly  2259 EK---EGADGSGD-GNDNEKAEATLDDDIEE--CYE----------------------------- 2288
            |.   .||:..|. .:|....:.:.||.::|  |.|
  Rat   432 ESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSTGSEKISKPGLEKVEMAETDQRKDSIQ 496

  Fly  2289 ----------YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAE 2343
                      |||..|.||:|:|.|||||:.||.      .:.::|:.|||..|.......| .:
  Rat   497 FQLGEPNSLMYELFSVMVHSGSAAGGHYYACIKS------FSDDQWYSFNDQHVSRITQEDI-KK 554

  Fly  2344 CFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERR-------------LPEHLQRRHSELLVT 2395
            ..||...|:.|.|       .:|..:.:||||.|..:             .|||::.
  Rat   555 THGGSSGSRGYYS-------SAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKN-------- 604

  Fly  2396 PTPSPTVEEKSEAEEPTK----METSSSEIK-------ADVDVEVEVE-EKDKEKPAQTDTESKE 2448
                 .|:::.|.||..|    :|.::.:||       ..|.:|.::| .|||......:...|.
  Rat   605 -----LVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKM 664

  Fly  2449 TPAKEEIADD---KSKQDEPEEKKIEKQSREGEE 2479
            ...::.|..|   ..|.||..:  ..::|.||||
  Rat   665 MDLEDVIPLDCCRLVKYDEFHD--YLERSYEGEE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/436 (25%)
		UCH	2014..2377	CDD:278850	106/417 (25%)
		DUF3517	2723..>2877	CDD:288853
Usp47	XP_006230106.1	peptidase_C19C	186..586	CDD:239124	108/423 (26%)
Usp47	XP_006230106.1	UCH	187..581	CDD:278850	106/417 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810