Protein Alignment puf and Usp18

DIOPT Version :10

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_036039.2
• Gene: Usp18 / 24110
• MGIID: 1344364
• Length: 368
• Species: Mus musculus
• Alignment Length: 441
• Identity: 97/441 - (21%)
• Similarity: 166/441 - (37%)
• Gaps: 96/441 - (21%)

  Fly  1951 QKPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYV 2015
            :|| |:|..:....|..|.|       .......|:|::....     .||        :..|.|
Mouse     9 RKP-CQSVVAEPQQYSALEE-------ERTMKRKRVLSRDLCS-----AWD--------SPHGLV 52

  Fly  2016 GLTNLGATCYMASCVQHLYMMPQARAAVLR---VPPNAARKHGPTLLELQRMFAYLLESERKSYN 2077
            ||.|:|.||.:.|.:| ::||......:|:   ||.:|..:......:|..:...:.:|.:|:..
Mouse    53 GLHNIGQTCCLNSLLQ-VFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQKAVL 116

  Fly  2078 PRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDM--TPDLKHLVKRLFCGSLSNNVVSLDCG 2140
            |....:..|..:.||..  |.|.|:.::.:.:..:|.  ..||...::.||......:::.:.|.
Mouse   117 PTELVQCLQKYNVPLFV--QHDAAQLYLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCT 179

  Fly  2141 HVSRTAEDFYTVRCQVAD-----MRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKK 2200
            ..|.......|:...:.|     ::.|:::|........|...:| .|..||:|...::......
Mouse   180 AESSRRSKLLTLSLPLFDKDAKPLKTLEDALRCFVQPKELASSDM-CCESCGEKTPWKQVLKLTH 243

  Fly  2201 LPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYV--EKTLMPQQYKEERERRQKEKEGA 2263
            |||.|..:.||  |:......||:....:||..|:....:  |:.|
Mouse   244 LPQTLTIHLMR--FSARNSRTEKICHSVNFPQSLDFSQVLPTEEDL------------------- 287

  Fly  2264 DGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFN 2328
                 |:..|::|          ..|||..|..|.|.||.|||.::|:.      ....:||.||
Mouse   288 -----GDTKEQSE----------IHYELFAVIAHVGMADFGHYCAYIRN------PVDGKWFCFN 331

  Fly  2329 DAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYER 2379
            |:.|           |:      .|:..|...|.:..:....:||:|.|.:
Mouse   332 DSHV-----------CW------VTWKDVQCTYGNHRYRWRETAYLLVYTK 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	86/379 (23%)
		DUF3517	2648..>2884	CDD:463438
		MDN1	<3661..>3887	CDD:444083
Usp18	NP_036039.2	Mediates interaction with IFNAR2. /evidence=ECO:0000250|UniProtKB:Q9UMW8	31..48		4/29 (14%)
		Mediates interaction with STAT2. /evidence=ECO:0000250|UniProtKB:Q9UMW8	48..109		17/61 (28%)
		UCH	52..363	CDD:425685	84/373 (23%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000250|UniProtKB:Q9UMW8	299..308		4/8 (50%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000250|UniProtKB:Q9UMW8	309..368		20/80 (25%)