Protein Alignment puf and Usp28

DIOPT Version :10

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: XP_006510322.1
• Gene: Usp28 / 235323
• MGIID: 2442293
• Length: 1143
• Species: Mus musculus
• Alignment Length: 1282
• Identity: 251/1282 - (19%)
• Similarity: 411/1282 - (32%)
• Gaps: 496/1282 - (38%)

  Fly  1804 GNAHSYRLLLAPL-----------LHKLIALLPLAEQMSSGN--QHTQFLLSEEGKDPYGPACRD 1855
            |:..|.::||..|           ||:       |.:.|:|:  |....|..:..|:|
Mouse    16 GHGSSCQMLLNQLREITGIQDPSFLHE-------ALKASNGDITQAVSLLTDQRVKEP------- 66

  Fly  1856 YFWLLARLVDTLSPEMVAEEHIDIEMLCESISQSILTREYYELRHGYQDDGLVGLLNLMSNLIKY 1920
                        |.:..|.|..::|   ||.:...|..:..:|.|..:||....:
Mouse    67 ------------SHDTTAAEPSEVE---ESATSKDLLAKVIDLTHDNKDDLQAAI---------- 106

  Fly  1921 DTTFKYTPKALSFIEQLIGFLFDMPSP---AD----RQKPKCKSASSRASAYDLLVELCRGCATN 1978
                     |||.:|          ||   ||    .:..:..||.::.|..    :.|.....|
Mouse   107 ---------ALSLLE----------SPNIQADNRDLNRAHEANSAETKRSKR----KRCEVWGEN 148

  Fly  1979 YAYLHGRLLAQHKSGPKQPYPW---DYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQAR 2040
            :                .|..|   |.||          |||.|:|.||:.::.:|.|:.:|:.|
Mouse   149 H----------------NPNNWRRVDGWP----------VGLKNVGNTCWFSAVIQSLFQLPEFR 187

  Fly  2041 AAVL--RVPPNA---ARKHGPT-----LLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTG 2095
            ..||  .:|.|.   .|.|...     :.|||.:||.||.|.||..:|.:...:.:...:. :..
Mouse   188 RLVLSYNLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRS-SEE 251

  Fly  2096 EQKDMAEFFIDLVSKLED-----------MTPDLKHLVKRLFCGS-LSNNVVSLDCGHVSRTAED 2148
            :|:|::||...|:..|||           :....::.:.:||.|: |:..|..   |......|.
Mouse   252 QQQDVSEFTHKLLDWLEDAFQLAVNVNSHLRNKSENPMVQLFYGTFLTEGVRE---GKPFCNNET 313

  Fly  2149 FYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYT 2213
            |.....||....||.|.|:...|    |||.....|.  :.|:..:...|.|||.:|.|...|:.
Mouse   314 FGQYPLQVNGYHNLDECLEGAMV----EGDIALLPSD--RSVKYGQERWFTKLPPVLTFELSRFE 372

  Fly  2214 FNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEK------------------ 2260
            ||......||::....||..:.|..|:.|:....:.|.|..|:.||:
Mouse   373 FNQSLGQPEKIHNKLEFPQIIYMDRYMYKSKELIRSKRESVRKLKEEIQVLQQKLERYVKYGSGP 437

  Fly  2261 ----------------------------------------------------------------- 2260
                                                                             
Mouse   438 SRFPLPDMLKYVIEFASTKPASESCLSGSAEHVTLPLPSVHCPISDLTPKESSSPESCSQNAGST 502

  Fly  2261 ----EGADGSGDG-----------------------NDNE-----------KAEATLD-DDIEEC 2286
                |.|..|.:|                       .|.|           ::|...| .|::.|
Mouse   503 FSSPEDALPSSEGMNGPFTSPHSSLETPAPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNC 567

  Fly  2287 YE-------------------YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEV 2332
            ..                   |.|..|.||.|.|..|||:::|..:.:      :.|..:||..|
Mouse   568 ISSSTKAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPR------QTWLKYNDISV 626

  Fly  2333 KPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPT 2397
            ......::..:.:||                   .:..|||.|.|   :.::|
Mouse   627 TESSWEELERDSYGG-------------------LRNVSAYCLMY---INDNL------------ 657

  Fly  2398 PSPTVEEKSEAEEPT--KMETSSSEIKADVD-----VEVEVEEKDKEK-------------PAQT 2442
            |..:.|..|...:.|  ::|..|.|::..:.     .:.||||.::|:             .:|.
Mouse   658 PHFSAEASSNESDETAGEVEALSVELRQYIQEDNWRFQQEVEEWEEEQSCKIPQMESSPNSSSQD 722

  Fly  2443 DTESKETP-----------------AKEEIADDKSKQDEPEEKK-IE---KQSREGEEKSETDEK 2486
            .:.|:|:|                 |||:.|...:......||. :|   .:..|.|.|     |
Mouse   723 FSTSQESPAVSSHEVRCLSSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEHNEAEPK-----K 782

  Fly  2487 PTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELEDWIWQD 2551
            |.|   .:..|:.:..|...:.:.....||:.|..:.||..         |.|:..:.:.:   |
Mouse   783 PQE---TNLAEQLEQAAEARDTEAAAAPNSEVSEVEIPSVG---------RILVRSDADGY---D 832

  Fly  2552 NRQFLQ-----------------DRNIFE-------HTYFNFMWQICGHIPQSLISETDVTCMAA 2592
            ....|.                 ||:..|       |..::.::|:....|   .|.:|....
Mouse   833 EEVMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETP---TSHSDPRLQ-- 892

  Fly  2593 KLSVSFFIETFIHAKEKPTMVPWVE-LLTKQF---NASQEACEWFLSHMSQEPYWPVQVLIQCPN 2653
            .:.|.||      ..|.|..|  || .|.:||   |.|.:.....:..::|.....:.     |:
Mouse   893 HVLVYFF------QNEAPKRV--VERTLLEQFADRNLSYDERSISIMKVAQAKLMEIG-----PD 944

  Fly  2654 QMVRQ----------MFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIGSLISL 2708
            .|..:          :|:::.::::..|.......|.|.                       :|.
Mouse   945 DMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEA-----------------------LSY 986

  Fly  2709 LEHGARANLRHLSEYFGLLCEFSRMGDEE---AMY----LLRIGV-LKSLVDFYLGHKQTDSIDI 2765
            |.:..::|.       |||.:..|.|.:|   |:|    ||.:.. ..||.:....|..|:.|::
Mouse   987 LVYAYQSNA-------GLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINV 1044

  Fly  2766 SSD----------NEDNSSEEALSVEKMRP---ASLDKMIA----LC 2795
            .::          |.|.|.::..::|.||.   :.|.|.||    ||
Mouse  1045 MNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQLC 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	109/531 (21%)
		DUF3517	2648..>2884	CDD:463438	36/183 (20%)
		MDN1	<3661..>3887	CDD:444083
Usp28	XP_006510322.1	UBA_UBP28	23..64	CDD:270540	10/47 (21%)
		Peptidase_C19I	163..653	CDD:239130	108/527 (20%)
		Peptidase_C19	163..>267	CDD:470612	32/104 (31%)
		USP28_C	864..1143	CDD:380452	55/276 (20%)