DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment puf and Usp28

DIOPT Version :9

Sequence 1:NP_001262923.1 Gene:puf / 42935 FlyBaseID:FBgn0039214 Length:3930 Species:Drosophila melanogaster
Sequence 2:XP_006510322.1 Gene:Usp28 / 235323 MGIID:2442293 Length:1143 Species:Mus musculus


Alignment Length:1282 Identity:251/1282 - (19%)
Similarity:411/1282 - (32%) Gaps:496/1282 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1804 GNAHSYRLLLAPL-----------LHKLIALLPLAEQMSSGN--QHTQFLLSEEGKDPYGPACRD 1855
            |:..|.::||..|           ||:       |.:.|:|:  |....|..:..|:|       
Mouse    16 GHGSSCQMLLNQLREITGIQDPSFLHE-------ALKASNGDITQAVSLLTDQRVKEP------- 66

  Fly  1856 YFWLLARLVDTLSPEMVAEEHIDIEMLCESISQSILTREYYELRHGYQDDGLVGLLNLMSNLIKY 1920
                        |.:..|.|..::|   ||.:...|..:..:|.|..:||....:          
Mouse    67 ------------SHDTTAAEPSEVE---ESATSKDLLAKVIDLTHDNKDDLQAAI---------- 106

  Fly  1921 DTTFKYTPKALSFIEQLIGFLFDMPSP---AD----RQKPKCKSASSRASAYDLLVELCRGCATN 1978
                     |||.:|          ||   ||    .:..:..||.::.|..    :.|.....|
Mouse   107 ---------ALSLLE----------SPNIQADNRDLNRAHEANSAETKRSKR----KRCEVWGEN 148

  Fly  1979 YAYLHGRLLAQHKSGPKQPYPW---DYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQAR 2040
            :                .|..|   |.||          |||.|:|.||:.::.:|.|:.:|:.|
Mouse   149 H----------------NPNNWRRVDGWP----------VGLKNVGNTCWFSAVIQSLFQLPEFR 187

  Fly  2041 AAVL--RVPPNA---ARKHGPT-----LLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTG 2095
            ..||  .:|.|.   .|.|...     :.|||.:||.||.|.||..:|.:...:.:...:. :..
Mouse   188 RLVLSYNLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRS-SEE 251

  Fly  2096 EQKDMAEFFIDLVSKLED-----------MTPDLKHLVKRLFCGS-LSNNVVSLDCGHVSRTAED 2148
            :|:|::||...|:..|||           :....::.:.:||.|: |:..|..   |......|.
Mouse   252 QQQDVSEFTHKLLDWLEDAFQLAVNVNSHLRNKSENPMVQLFYGTFLTEGVRE---GKPFCNNET 313

  Fly  2149 FYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYT 2213
            |.....||....||.|.|:...|    |||.....|.  :.|:..:...|.|||.:|.|...|:.
Mouse   314 FGQYPLQVNGYHNLDECLEGAMV----EGDIALLPSD--RSVKYGQERWFTKLPPVLTFELSRFE 372

  Fly  2214 FNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEK------------------ 2260
            ||......||::....||..:.|..|:.|:....:.|.|..|:.||:                  
Mouse   373 FNQSLGQPEKIHNKLEFPQIIYMDRYMYKSKELIRSKRESVRKLKEEIQVLQQKLERYVKYGSGP 437

  Fly  2261 ----------------------------------------------------------------- 2260
                                                                             
Mouse   438 SRFPLPDMLKYVIEFASTKPASESCLSGSAEHVTLPLPSVHCPISDLTPKESSSPESCSQNAGST 502

  Fly  2261 ----EGADGSGDG-----------------------NDNE-----------KAEATLD-DDIEEC 2286
                |.|..|.:|                       .|.|           ::|...| .|::.|
Mouse   503 FSSPEDALPSSEGMNGPFTSPHSSLETPAPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNC 567

  Fly  2287 YE-------------------YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEV 2332
            ..                   |.|..|.||.|.|..|||:::|..:.:      :.|..:||..|
Mouse   568 ISSSTKAIEQMYCDPLLRQVPYRLHAVLVHEGQASAGHYWAYIYNQPR------QTWLKYNDISV 626

  Fly  2333 KPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPT 2397
            ......::..:.:||                   .:..|||.|.|   :.::|            
Mouse   627 TESSWEELERDSYGG-------------------LRNVSAYCLMY---INDNL------------ 657

  Fly  2398 PSPTVEEKSEAEEPT--KMETSSSEIKADVD-----VEVEVEEKDKEK-------------PAQT 2442
            |..:.|..|...:.|  ::|..|.|::..:.     .:.||||.::|:             .:|.
Mouse   658 PHFSAEASSNESDETAGEVEALSVELRQYIQEDNWRFQQEVEEWEEEQSCKIPQMESSPNSSSQD 722

  Fly  2443 DTESKETP-----------------AKEEIADDKSKQDEPEEKK-IE---KQSREGEEKSETDEK 2486
            .:.|:|:|                 |||:.|...:......||. :|   .:..|.|.|     |
Mouse   723 FSTSQESPAVSSHEVRCLSSEHAVIAKEQTAQAIANTAHAYEKSGVEAALSEHNEAEPK-----K 782

  Fly  2487 PTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELEDWIWQD 2551
            |.|   .:..|:.:..|...:.:.....||:.|..:.||..         |.|:..:.:.:   |
Mouse   783 PQE---TNLAEQLEQAAEARDTEAAAAPNSEVSEVEIPSVG---------RILVRSDADGY---D 832

  Fly  2552 NRQFLQ-----------------DRNIFE-------HTYFNFMWQICGHIPQSLISETDVTCMAA 2592
            ....|.                 ||:..|       |..::.::|:....|   .|.:|....  
Mouse   833 EEVMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETP---TSHSDPRLQ-- 892

  Fly  2593 KLSVSFFIETFIHAKEKPTMVPWVE-LLTKQF---NASQEACEWFLSHMSQEPYWPVQVLIQCPN 2653
            .:.|.||      ..|.|..|  || .|.:||   |.|.:.....:..::|.....:.     |:
Mouse   893 HVLVYFF------QNEAPKRV--VERTLLEQFADRNLSYDERSISIMKVAQAKLMEIG-----PD 944

  Fly  2654 QMVRQ----------MFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIGSLISL 2708
            .|..:          :|:::.::::..|.......|.|.                       :|.
Mouse   945 DMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEA-----------------------LSY 986

  Fly  2709 LEHGARANLRHLSEYFGLLCEFSRMGDEE---AMY----LLRIGV-LKSLVDFYLGHKQTDSIDI 2765
            |.:..::|.       |||.:..|.|.:|   |:|    ||.:.. ..||.:....|..|:.|::
Mouse   987 LVYAYQSNA-------GLLVKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGINV 1044

  Fly  2766 SSD----------NEDNSSEEALSVEKMRP---ASLDKMIA----LC 2795
            .::          |.|.|.::..::|.||.   :.|.|.||    ||
Mouse  1045 MNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGKDIAENLQLC 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pufNP_001262923.1 peptidase_C19C 2013..2382 CDD:239124 109/531 (21%)
UCH 2014..2377 CDD:278850 108/525 (21%)
DUF3517 2723..>2877 CDD:288853 27/98 (28%)
Usp28XP_006510322.1 UBA_UBP28 23..64 CDD:270540 10/47 (21%)
UBP14 <162..639 CDD:227532 102/492 (21%)
Peptidase_C19I 163..653 CDD:239130 108/527 (20%)
USP28_C 864..1143 CDD:380452 55/276 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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