Protein Alignment puf and USP24

DIOPT Version :9

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: XP_016856320.1
• Gene: USP24 / 23358
• HGNCID: 12623
• Length: 2640
• Species: Homo sapiens
• Alignment Length: 2989
• Identity: 631/2989 - (21%)
• Similarity: 1043/2989 - (34%)
• Gaps: 879/2989 - (29%)

  Fly   365 INAHINLFNEICTTE-----TVNEVELFGQRIANWLTENHIV-QHLFGPNLHVEIVKQAHVLLNF 423
            ::|..|..|..|:.|     |.|..||          |:.:: .|...|....|.:.:..:...:
Human   105 VDAEKNDENGNCSGEGIEFPTTNLYEL----------ESRVLTDHWSIPYKREESLGKCLLASTY 159

  Fly   424 LAVENQISEEDIKLIWQATQLKHCSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTE--QS 486
            || ...:||.|          ::|.:.:...:|...|.|....|:|          |..||  :.
Human   160 LA-RLGLSESD----------ENCRRFMDRCMPEAFKKLLTSSAVH----------KWGTEIHEG 203

  Fly   487 IYIASALTKQLWTRDTSRSQMNLMQDHLLGSNVTASSSDSGSIEGSNTEDDH----VGADDSSIA 547
            ||....|..:|   ...|.:.:.:...|||....|.:.|:         :.|    :.....:.|
Human   204 IYNMLMLLIEL---VAERIKQDPIPTGLLGVLTMAFNPDN---------EYHFKNRMKVSQRNWA 256

  Fly   548 SGGGGGGVGNKSPIDGVTPCKQARHRRHICDPTTEKGKQISPEDMAKVDLVNKRIVNIIDNTSSE 612
            ...|.|.:...||:.                 |.:|    .|.... ||||||           .
Human   257 EVFGEGNMFAVSPVS-----------------TFQK----EPHGWV-VDLVNK-----------F 288

  Fly   613 EELQSRAALELQLHRSRKKTSNKRR--------RQKTNKQIILPHELVEIWDGVEDVPSSDEADG 669
            .||...||::.:||....:......        .:..|..::.|.....|...::||.|.:|.|.
Human   289 GELGGFAAIQAKLHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKDL 353

  Fly   670 EADGDGEGELLADSDECS-----------DGAT--SQLVPDAVLKHLQGEGPFIRAIETNINELL 721
            :     :..|::..:..|           |..|  ..|..|.:|:.|  :.|...|...::.|:.
Human   354 K-----DKRLVSIPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRML--KSPHFSAKMNSLKEVT 411

  Fly   722 SGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCSDVPPAFAAAAAAMMVAQS 786
            ...|:     |.:| ||.||..|.|            :|:.                  .:|..|
Human   412 KLIED-----STLS-KSVKNAIDTD------------RLLD------------------WLVENS 440

  Fly   787 AMALQKSGESNVAAAAAAVAAAAAATG---------------TAQQTLVAMNRQASVAAAAAVVA 836
            .:::...|..:.|.....:.......|               :.|.:.|..|....:||     |
Human   441 VLSIALEGNIDQAQYCDRIKGIIELLGSKLSLDELTKIWKIQSGQSSTVIENIHTIIAA-----A 500

  Fly   837 AAKAKSDSDVDLMDVVSGGKQHHSPKASQG--------------SSTSGSTPVQPSFKLNDVCQP 887
            |.|..||....|..::....:..|.:..|.              .:|||        |:.||
Human   501 AVKFNSDQLNHLFVLIQKSWETESDRVRQKLLSLIGRIGREARFETTSG--------KVLDV--- 554

  Fly   888 GNTLLWDLLQDDKIGQLGESLALEAEKALATLL--CFSMDRQLRTKFIEGCL------------- 937
                ||:|..   :..|..||..:|.:...|:|  .:::...::..:|..|:
Human   555 ----LWELAH---LPTLPSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIEDIKRPGEWSGLE 612

  Fly   938 ---------------------YNVANNRS----------VIVSLRLLPKLFASF--QQFRPSDTH 969
                                 |.....||          |:.:||.|.::..||  |.::..| .
Human   613 KNKKDGFKQGGLTGDYVSLPGYTETKQRSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQD-K 676

  Fly   970 SMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQNGEQQQQQLGGQLYSHKTQVSVRLQFLSSIF 1034
            |:....::|..:::....:: ....|.|..:....|......:.|: |:::..:...|:||:...
Human   677 SIIQDLKKNFEIVKLVTGSL-IACHRLAAAVAGPGGLSGSTLVDGR-YTYREYLEAHLKFLAFFL 739

  Fly  1035 STVGSPKSFRLTLEQLDALWEWLAHDPECAD-----CYFSWLQAQAKGGDQHALGIEALQHLYLK 1094
            ...    :..|...:...:||.|....:..:     | |.|.   .||  ||.|..:..|.|:.:
Human   740 QEA----TLYLGWNRAKEIWECLVTGQDVCELDREMC-FEWF---TKG--QHDLESDVQQQLFKE 794

  Fly  1095 KLPELRPEEFSMVALGLFQQLCSFARIAMAEYDNHSDQISA-SASAVGMYHLWKIALRAQSNDVS 1158
            |:.:|...|.:|....||:.......:..........|:.. ....:||..:||||:.:...:::
Human   795 KILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAMESPDEEIA 859

  Fly  1159 LAAIQ-YINMYYMGQQLRLEKE-------FVSQCMENLVQA------------------------ 1191
            ..||| .||..|:....||:|:       |::.|...|..|
Human   860 NEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTHAVTRATKMLTATA 924

  Fly  1192 ----ATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEGKGIGSHSNLKNEGAGP 1252
                ||:::|......|:.::|.|||...::.|....|:...   .|...|...|.:|
Human   925 MPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVPR---TILPHGASFHGHL------- 979

  Fly  1253 PLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESLQTGLAAPVLGLLLSDGPLRIITQGQE 1317
             |.:.:......:...::.|:.:.|..::.:::|       .|.:||       ..::|.|....
Human   980 -LTLNVTYESTKDTFTVEAHSNETIGSVRWKIAK-------QLCSPV-------DNIQIFTNDSL 1029

  Fly  1318 LTSDYDERSLGDAGFKDNQIVYVSLGGRG-----------ARRKESNLEHPSMLPPPPKECLP-T 1370
            ||.:.|::.|...||.|.||:.|...|.|           :....|:....|......::.|| .
Human  1030 LTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGV 1094

  Fly  1371 VLLLQPKYFEKLFCLMQTLGDMQPQASTVNPQHHTKAQLLSRRVWDILAMLPTNPHILDAFKSLV 1435
            |:.|....|:.|:.|          |:...|:       ::.||..:|.::||:|.|.:|
Human  1095 VMALVCNVFDMLYQL----------ANLEEPR-------ITLRVRKLLLLIPTDPAIQEA----- 1137

  Fly  1436 TDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQKFMYSLHIVESLALTSSRRGESNGNV 1500
                 |:|||:.|.::.|                                |:.:||
Human  1138 -----LDQLDSLGRKKTL--------------------------------LSESSS--------- 1156

  Fly  1501 AMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCELEAPLTPTPSTGLQDVETEASSS 1565
                        :||.....:|.:|..|....:      |..|.....|..||.......|..||
Human  1157 ------------QSSKSPSLSSKQQHQPSASSI------LESLFRSFAPGMSTFRVLYNLEVLSS 1203

  Fly  1566 SGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPTPPPPALSVVERGDNKWSEAFVKCGGL 1630
                            |...|.:.:..|  .|:                   ..:.|.|:|.|||
Human  1204 ----------------KLMPTADDDMAR--SCA-------------------KSFCENFLKAGGL 1231

  Fly  1631 RHLYEIFSEGQLQQSAHPKELALNEWRHD----CLASLLRILWLLG-------FEELQSADAHVL 1684
            ..:..:     :|:.:.|.|:.. |.|..    || .|.|.| |:|       .|:|.......|
Human  1232 SLVVNV-----MQRDSIPSEVDY-ETRQGVYSICL-QLARFL-LVGQTMPTLLDEDLTKDGIEAL 1288

  Fly  1685 MSRPH------------------------------------------PFMLQLMEVPQ------C 1701
            .|||.                                          ...:|.|||..      |
Human  1289 SSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVSDFTSTVAC 1353

  Fly  1702 LTRLS---------------------SILNDEVHQQHQASSAN--------PLVFPYQFQHLRTG 1737
            ..|||                     |:....:..:..:|.:|        |:.       |..|
Human  1354 FMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVA-------LHAG 1411

  Fly  1738 FWGRAQLIQF--------AMNILVSFVHASAEARRLLW-APTGTDHCRWLQKFILEDPEPAVRRE 1793
            ...|.|.:..        |:::||:.:...::.....: .|...|   ::...:|..|...:||.
Human  1412 ICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVAD---FIIDILLGSPSAEIRRV 1473

  Fly  1794 ICAGLYRICLGNAHSY-------RLLLAPLLHKLIALLPLAEQMSSGNQHTQFLLSEEGKDPYGP 1851
            .|..||.:...:..::       :.||..:   |.|.|||....|......|.|||:
Human  1474 ACDQLYTLSQTDTSAHPDVQKPNQFLLGVI---LTAQLPLWSPTSIMRGVNQRLLSQ-------- 1527

  Fly  1852 ACRDYFWLLARLVDTL----------SPEMVAEEHI--------DIEMLCE-SISQSILTREYYE 1897
             |.:||.|..:|:|.|          ||..:.|:.|        :....|| |.:.:||...:..
Human  1528 -CMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLR 1591

  Fly  1898 LRHGYQDDGLVGLLNLM--------SNLIKYDTTFKYTPKALSFIEQLIGFLFDMPSPADRQ--- 1951
            |        :..||:|.        |:|||        |....|:.:....:.:..|||...
Human  1592 L--------IKTLLSLCGAEKEMLGSSLIK--------PLLDDFLFRASRIILNSHSPAGSAAIS 1640

  Fly  1952 ----KPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYP-----WDYWPRDE 2007
                .|||.:|:||.:||::||.|.....:|...:...||:.|    .||.|     :||.|..:
Human  1641 QQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMH----HQPDPALTKEFDYLPPVD 1701

  Fly  2008 GRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESE 2072
            .|:..|:|||.|.||||||.:..|.|||.|....::|.|..:..........::|.:|.:|:||:
Human  1702 SRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMESK 1766

  Fly  2073 RKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDL--KHLVKRLFCGSLSNNVV 2135
            .:.|.|.:|.::::|.::.|...||:|..|||..|:.::::....:  ..:.|..|.|..|:..:
Human  1767 LQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQKI 1831

  Fly  2136 SLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKK 2200
            ..||.|.....|.|..:...|...::|:.|||:....:.|||.|.|.|.:|.:|....||.|.|.
Human  1832 CKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKS 1896

  Fly  2201 LPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADG 2265
            ||.:|..:.||:.|:..:....|.:....||..|||..|....:..|....|.....:   ..|.
Human  1897 LPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGR---SVDQ 1958

  Fly  2266 SGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDA 2330
            .|.|:..:|...|        ..||||||.||:|.|..||||||||:|....   ..:|:.|||.
Human  1959 GGGGSPRKKVALT--------ENYELVGVIVHSGQAHAGHYYSFIKDRRGCG---KGKWYKFNDT 2012

  Fly  2331 EVKPFD--PSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELL 2393
            .::.||  ...:..||||||...|.||. |..|.|......| ||||||:|
Human  2013 VIEEFDLNDETLEYECFGGEYRPKVYDQ-TNPYTDVRRRYWN-AYMLFYQR-------------- 2061

  Fly  2394 VTPTPSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADD 2458
            |:...||.:.:||....                |..|.|:.           |...|:..||
Human  2062 VSDQNSPVLPKKSRVSV----------------VRQEAEDL-----------SLSAPSSPEI--- 2096

  Fly  2459 KSKQDEPEEKKIEKQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQ 2523
             |.|..|                    :|                    |:.||:..|..:
Human  2097 -SPQSSP--------------------RP--------------------HRPNNDRLSILT---- 2116

  Fly  2524 PSTSKAAQKLQLFRPLLNKELEDWIWQDNRQFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVT 2588
             ...|..:|..||...:...:...:..:|.:|:::|:::...||:|:..:.. :..:.:......
Human  2117 -KLVKKGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLAS-LNATKLKHPYYP 2179

  Fly  2589 CMA---AKLSVSFFIETFIHAKEKPTM--VPWV----ELLTKQFNASQEACEWFLSHMSQEPYWP 2644
            |||   .:|::.|..:|::..|:|..:  ..|:    .||:|.|:|.|...|:|:|...:|   .
Human  2180 CMAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISSEGRE---L 2241

  Fly  2645 VQV-LIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIGSLISL 2708
            ::: |::|   .||::  |:.:..|.:.....|..|       .||     ...:.:.:..|::|
Human  2242 IKIFLLEC---NVREV--RVAVATILEKTLDSALFY-------QDK-----LKSLHQLLEVLLAL 2289

  Fly  2709 LEHGARANLRHLSEYFGLLCEF-SRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDN 2772
            |:.....|.::.::||.|...| .:.|......|||...|:.::.|.||          :..::|
Human  2290 LDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLG----------ASRQNN 2344

  Fly  2773 SSEEALSVEKMRPASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGIN 2837
            ......|.:.....:|...:||   ||..|..:..| .::|..|.            |:....|.
Human  2345 QIRRWSSAQAREFGNLHNTVAL---LVLHSDVSSQR-NVAPGIFK------------QRPPISIA 2393

  Fly  2838 PHQTKHLIHALCRWDERLATQIIGMLFASVTKHTELCAPF-FKLLTLLTETQGGPVGLPCFTQLI 2901
            |......:|          .::..:||.|..|      |: .:::..|.|..|..:.|   .:::
Human  2394 PSSPLLPLH----------EEVEALLFMSEGK------PYLLEVMFALRELTGSLLAL---IEMV 2439

  Fly  2902 LPRMWDAAEYC--PQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVA 2964
            :        ||  ......:..|...||::..|    ...:....|.|.|:          :||.
Human  2440 V--------YCCFCNEHFSFTMLHFIKNQLETA----PPHELKNTFQLLHE----------ILVI 2482

  Fly  2965 LVPSQPFRANFRAHSQHKLLALNPHSYRDINSDAQAVLHQVITLLLRLLR---PARVYADIGAH 3025
            ..|.|..|..|...:::.||||..||    |....:..:|.:..|:.|.:   .|:.|....:|
Human  2483 EDPIQVERVKFVFETENGLLALMHHS----NHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSH 2542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	126/372 (34%)
		UCH	2014..2377	CDD:278850	122/366 (33%)
		DUF3517	2723..>2877	CDD:288853	31/154 (20%)
USP24	XP_016856320.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820