DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and math-33

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	NP_001294689.1	Gene:	math-33 / 179538	WormBaseID:	WBGene00010406	Length:	1138	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	187/832 - (22%)
Similarity:	319/832 - (38%)	Gaps:	202/832 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1963 SAYDLLVELCR---GCATNYAY-LHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGAT 2023
            |.||....||.   |...|... |..|..|...:|..  |.||      .:...|.:||.|.|||
Worm   148 SNYDQYDTLCNPKDGYVVNDTIKLRCRFTADVPTGAN--YMWD------SKRHTGCIGLRNQGAT 204

  Fly  2024 CYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMD 2088
            |||.|.:|..|.....|.||..:...........:|.:||:| |.|:...::....|..|.:..|
Worm   205 CYMNSILQSFYFTTGFRRAVYNMDVGTEPNESNIVLAMQRVF-YELQMASEAVETNSLTRAFGWD 268

  Fly  2089 HQPLNTGEQKDMAEFFIDLVSKLEDM---TPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFY 2150
              .|:...|.|:.||...|:..||..   |.:.|. :..||.|::.:.:..||..:.|...|.||
Worm   269 --KLDAFNQHDVQEFCRVLLDNLETKMKGTSEEKS-IPNLFRGNMKSYIKCLDVDYESSRTESFY 330

  Fly  2151 TVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFN 2215
            .|:..|..|.:|:.:.:..|..:.|:.:|.|.....|.: ||||...|.:||.||....||:.:.
Worm   331 DVQLNVLGMDSLERAFEAYTTSEILDDENKYDAGDHGLQ-RAEKGVKFVELPPILHVQLMRFQYC 394

  Fly  2216 MVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLD 2280
            .|   ::|:|..||||.::|:....|...|..:
Worm   395 GV---EQKINERFSFPEKMNLASCCELGPMLTE-------------------------------- 424

  Fly  2281 DDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAEC- 2344
               |:|. |.|..|.||:|...||||.::|      :.:.||          ...||:..|..|
Worm   425 ---EDCV-YSLHAVLVHSGEFHGGHYVTYI------NVNLHE----------SAVDPTSSAKWCK 469

  Fly  2345 FGGEMTSKTY--DSVTEKYLDFSFEKT--NSAYMLFYER--------------RLPEHLQR---- 2387
            |..::.|:|.  |::..   :|..|||  :|||||.|.|              ::|:.:.|
Worm   470 FDDDVVSRTTTDDAIVS---NFGGEKTMNSSAYMLVYVRDNAIDQFLAPIPDSQIPQSVSRTFEM 531

  Fly  2388 ----RHSE-------------LLVTP-----TPSPTVEEKSEAEEPTKMETSSSEIKADVDVEVE 2430
                |:.|             :||||     ..|..:.::|...:....||....: ...::...
Worm   532 ERLHRNREKKKLEEEQLCMGIVLVTPDIVASNHSFDLVDQSIVHDSIPHETVWKHM-FTAELYQF 595

  Fly  2431 VEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEE-KKIEKQSREGEEKSETDEKPTEMTTVS 2494
            |.::..||.|....:..:       :||:::|...:. ::|:.:.........||....|.||..
Worm   596 VHDRLFEKSAMQKIDMFD-------SDDEARQARRDNLRRIKSKKFNFRLWRMTDSYSLERTTQK 653

  Fly  2495 TEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELEDWIWQDNRQFLQDR 2559
            .....:|:...| .:.:...::..|.|.:....:.:..::  |||..        .|..:.|
Worm   654 LTSRLRPSEFID-CKTDTRLDTLLSQDFETIYVEFSNNIE--RPLCE--------YDTARDL--- 704

  Fly  2560 NIFEHTYFNFM---WQICGH----------IPQSLISETDVTCMAAKLSVSFFIETFIHAKEKPT 2611
             :|...|::.|   :.|.||          :.:|::.|  :..:.|...:.:::|   ||
Worm   705 -LFFVKYYDTMTDKFTIIGHTMFDCHKRFNLYRSMLCE--MIGLPADTELKYYME---HA----- 758

  Fly  2612 MVPWVEL--LTKQFNASQEACEWFLSHMSQEPYWPVQVL--------IQCPNQMVRQMFQRLVIH 2666
             ..::||  ||:.::         :..:.:|....:.|:        .|...|.:.::|..:.:.
Worm   759 -ASYLELVDLTQNYS---------IGRLVEEQDGGILVVEKVETSTSTQNAKQKMNELFLDVEVE 813

  Fly  2667 VIQQLRASHAHLYLEVETDEDDKELIGQASCVTRFIGSLISLLEH-GARANL 2717
            .:|.        :...:.:|:..|...:..|:.   ..|.::.|. |||.|:
Worm   814 FVQS--------FYNKKPEEEPFEQFVKRICLD---DKLFTVAEEIGARLNV 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/390 (28%)
		UCH	2014..2377	CDD:278850	105/370 (28%)
		DUF3517	2723..>2877	CDD:288853
math-33	NP_001294689.1	COG5077	4..1136	CDD:227409	187/832 (22%)
		MATH	30..182	CDD:295307	10/33 (30%)
		peptidase_C19C	194..507	CDD:239124	108/375 (29%)
		USP7_ICP0_bdg	636..863	CDD:289221	45/265 (17%)
		USP7_C2	900..1125	CDD:291217
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910