DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and K02C4.3

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	NP_001309441.1	Gene:	K02C4.3 / 174300	WormBaseID:	WBGene00010502	Length:	1261	Species:	Caenorhabditis elegans

Alignment Length:	1098	Identity:	185/1098 - (16%)
Similarity:	325/1098 - (29%)	Gaps:	441/1098 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2016 GLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNA------------ARKHGPTLLELQRMFAYL 2068
            ||.|.|.||::....|.||.:|:.|:.:....|.:            .::|...|:..:.:||.|
Worm   169 GLYNSGNTCWLNCLSQVLYSIPKFRSILYHCAPLSWHEQPITNVKIENQQHAELLMLFRGLFAEL 233

  Fly  2069 LESERK--SYNP--RSFCRVYQMDHQPLNTGEQKDMAE---FFIDLVSKLED------MTP---- 2116
            ..||.|  ...|  ....::.:....|...|.|:|..|   ...|.:.:..|      :.|
Worm   234 QFSEMKYIEVGPLINMVDKLSKSSKGPSTIGTQQDATEMLTLIFDWLQRAFDAALHAQLNPEFSN 298

  Fly  2117 --DLKHLV--------------------------------------------------------- 2122
              |.::||
Worm   299 VSDEENLVISDSTTTAPNSDIIGAPPGYNAANLSLPSSSHVDPKSTLNPMYVNEKEPSSTPTSLF 363

  Fly  2123 ------------------------------------------KRLFCGSLS---NNVVSLDC--- 2139
                                                      |:.||..|.   ||:.|..|
Worm   364 GTRSKTIEVNESMDTEAATSSNLPGNSVENHPNPAAPEVDDNKKAFCDKLKESFNNIFSSVCYTE 428

  Fly  2140 -----GHVS-----RTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEK 2194
                 |.||     |....|:.::....   ||.::|:..|....|..    |.|..
Worm   429 SVAEDGTVSVKSNVRNCPQFFQLQVTYG---NLHDALEAATFDHGLGN----TASHV-------- 478

  Fly  2195 RACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVE------------KTLMPQ 2247
            |..:..||.::.|...|::||  :.::.|::..|:||..:.|..|::            :.|...
Worm   479 RNLYDPLPAVIFFGLSRFSFN--SNIESKLHDKFTFPKIIFMDRYLKCNKEQLVQLRSHRELCRD 541

  Fly  2248 QYKEERERRQKEKEGADGSG----------------------DGNDNE----------------- 2273
            ...|.|.:....:....|:|                      |.::|.
Worm   542 SLSEVRAKLSGLRRYPQGNGEVRLEDSFQTVWQAVSNFRDREDAHENTAFVGPLTPSTYQSSSDN 606

  Fly  2274 -----------------------KA-----------------------EATLDDDIEECYE---- 2288
                                   ||                       ||.|.:.|::.||
Worm   607 CSSKFVKDGGKLFPTFTEGFFPGKAAFIETLQNMLEALKTEERDCLAEEARLQEVIDQTYEVPEL 671

  Fly  2289 ----YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEM 2349
                |||..:.||:|.|:.|||:::   :.|.|....|.|...||......|..::.::.||
Worm   672 QQHKYELHAIIVHSGEANRGHYWTY---KLKKSIDGLEEWEKLNDQNADRVDWPKVESDSFG--- 730

  Fly  2350 TSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHL--QRRHSELLVTPTPSPTVEEK-----SE 2407
             :.:.|:             .|||||.|.|...|.|  ..:.:.|....|..|.::||     .|
Worm   731 -TGSRDA-------------PSAYMLMYVRSDAEWLVSADKLTALEAFETIPPDLQEKVLQKRDE 781

  Fly  2408 AEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPA-----KEEIAD--------DK 2459
            .:|..:....:.|.        ..::...:.|....||  |||:     ::|:.|        :.
Worm   782 FKEKLQRFRENKEF--------NYQQFSVDSPTVQSTE--ETPSSFSWYRDELEDIDIGDENANP 836

  Fly  2460 SKQDEPEEKKIEKQS-------REGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQN------ 2511
            :|.|.....:::..|       ...|.|....:...::|.::..:........|::.::
Worm   837 TKNDYLLNARLDSYSVPIAPDVETSEMKRMVSQMWNQITKIAPRKYTDSQDLLDSNLRSVMEGES 901

  Fly  2512 ---NNSNSKASNDQQPSTSKAAQKLQ-LFRPLLNKEL---EDWIWQDNRQFLQDRNIFEHTYFNF 2569
               |..||:...|.....|.|...:: ::...:|:.|   :|.....|.:|:        .:..|
Worm   902 GGINFINSRLGYDIHELRSDADNDVEGVYNAFINEYLGLVKDLHELQNSKFV--------VFVGF 958

  Fly  2570 MWQICGHIP--------QSLISETDVTCMAAKLSVSFFIETFIHAKEKPTMVPWVELLTKQF--- 2623
            ..|.. |:|        ...:||..:....|...:|....   ::.:|.|.:..:.||...|
Worm   959 QLQRI-HVPVLRYLLVRAMAVSELGIISQRANNELSGMSS---NSHDKGTAMLQIALLLSHFFEL 1019

  Fly  2624 -NASQEACEWFLSHMSQEPYWPVQVLIQ----------------------------CPNQMVRQM 2659
             ..|...|...|.:        :.|::.                            | |.::|:|
Worm  1020 GVMSAWGCRSSLEN--------IHVILNDFKKKNSRGSEQIEVTYCAMIGARNARIC-NGLLREM 1075

  Fly  2660 FQRL-----------------------VIHVIQQLRASHAHLYLEVETDEDDKELIGQASCVTRF 2701
            ...|                       :|.:|.|..||.....:::|......|...:...:.|.
Worm  1076 AYFLESYSIFFVSQKHIEACTVFSTITMIKLIMQHMASKTLQLIDMEFHLSKNERRVRFEDIIRE 1140

  Fly  2702 IGSLISLLEHGARA------NLRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDF 2753
            :.|.:.::.|.:::      |..:|.|..|||             .|::..:.||..|
Worm  1141 VVSSVCIIHHWSKSYSKEFQNEINLKELMGLL-------------HLKVEFMVSLTSF 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	107/616 (17%)
		UCH	2014..2377	CDD:278850	105/611 (17%)
		DUF3517	2723..>2877	CDD:288853	7/31 (23%)
K02C4.3	NP_001309441.1	UCH	168..744	CDD:278850	105/611 (17%)
		Peptidase_C19I	169..745	CDD:239130	105/612 (17%)
		Peptidase_C19	169..>299	CDD:271592	29/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900