DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and Usp48

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_017175494.1	Gene:	Usp48 / 170707	MGIID:	2158502	Length:	1054	Species:	Mus musculus

Alignment Length:	956	Identity:	199/956 - (20%)
Similarity:	323/956 - (33%)	Gaps:	341/956 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1948 ADRQKPKCKSASSRASAYDLLVELC------RGCATNYAYLHGRLLAQHKSGPKQPYPWDYW--- 2003
            |:..:|:..|.....:||.:.:|.|      |.|..|...|.|  :.:|           .|
Mouse    15 AETVRPEEVSQEHIETAYRIWLEPCIRGVCRRNCRGNPNCLVG--IGEH-----------IWLGE 66

  Fly  2004 -----------PRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARK---- 2053
                       |..|.|.:..:|||||||||||:.:.:|..::..:.|.|:...|...:..
Mouse    67 IDENSFHSIDDPNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYTKGD 131

  Fly  2054 --HG------PTLLE-LQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVS 2109
              ||      .|:.| ||.:||.|..|.|:..:|..|.:...:|     ||:|:|..||....:|
Mouse   132 GIHGGKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLD-----TGQQQDAQEFSKLFMS 191

  Fly  2110 KLED-----MTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEV 2169
            .|||     ..||::::|::.|||..:...|...||..|:....||.:...:...:.|.:.:.|.
Mouse   192 LLEDTLSKQKNPDVRNVVQQQFCGEYAYVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEF 256

  Fly  2170 TVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRL 2234
            ..::.|||||.|.|..|..|..|.::.....||..|....||:.|:..|..|:|:|.:..|...|
Mouse   257 LKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESL 321

  Fly  2235 NMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG 2299
            :|..|||                 .|.|:                       :.|||..|.:|.|
Mouse   322 DMEPYVE-----------------HKGGS-----------------------FVYELSAVLIHRG 346

  Fly  2300 -TADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPS--QIAAECFGGEMTSKTYDSVTEKY 2361
             :|..|||.:.:|:...      ..|:.|||.:::..:..  |:..|    |..::...|.|.|
Mouse   347 VSAYSGHYIAHVKDPQS------GEWYKFNDEDIEKMEGKKLQLGIE----EDLAEPSKSQTRK- 400

  Fly  2362 LDFSFEK-------TNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSS 2419
                 .|       :.:||||.|..:..|   :.|:.:.|                |..::
Mouse   401 -----PKCGKGTHCSRNAYMLVYRLQAQE---KNHTMVQV----------------PAFLQ---- 437

  Fly  2420 EIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETD 2484
                      |:.::|..|..:...|..|. .|:.:  ||.|....|.|::.::...|.|
Mouse   438 ----------ELVDRDNSKFEEWCVEMAEM-RKQSV--DKGKAKHEEVKELYQRLPAGAE----- 484

  Fly  2485 EKPTEMTTVSTE------EEKQPTANCDNH----------------------------------- 2508
              |.|.  ||.|      :|..||...||:
Mouse   485 --PYEF--VSLEWLQKWLDESTPTKPIDNNACLCSHDKLHPDKISIMKRISEYAANIFYSRYGGG 545

  Fly  2509 ----------------------QQNNNSNSKASNDQQPSTSKAA-------QKLQLFRPLLNKEL 2544
                                  :...|.:.||.|:...||.|.:       ..|:.:|.|..::|
Mouse   546 PRLTVKALCKDCVVERCRVLRLKNQLNEDYKAVNNLLKSTMKGSDGFWVGKSSLRSWRQLALEQL 610

  Fly  2545 EDWIWQD---------------NRQFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVTCMAAKL 2594
            ::   ||               |:...::....|....||              ..|:.|...:|
Mouse   611 DE---QDGEAEQSNGKINGSTFNKDESKEEKKEEEEELNF--------------NEDILCPHGEL 658

  Fly  2595 SVSFFIETFIHAKEKPTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPV--QVLIQC------ 2651
            |:|         :.:..:|            ||||......:..:.|.:|.  :...||
Mouse   659 SIS---------ENERRLV------------SQEAWSKLQQYFPKAPEFPSYRECCSQCKILERE 702

  Fly  2652 --PNQMVRQMFQRLVIHVIQQLRASHAHLYLEVE--------TDEDDKELIGQ------------ 2694
              .|:.:.:|       :..:.:.|..:|:.:..        .|.|...::..
Mouse   703 GEENEALHKM-------IANEQKTSLPNLFQDKNRPCLSNWPEDTDALYIVSHFFLDEWRKFVRK 760

  Fly  2695 --ASCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEFSRMGDEEA 2738
              .|.....||:...|..||            ||:..|..:..|::
Mouse   761 PARSAPVSSIGNAALLCPHG------------GLMFTFPSLTKEDS 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/396 (27%)
		UCH	2014..2377	CDD:278850	107/390 (27%)
		DUF3517	2723..>2877	CDD:288853	4/16 (25%)
Usp48	XP_017175494.1	Peptidase_C19L	90..419	CDD:239133	106/389 (27%)
		DUSP	484..554	CDD:368848	11/78 (14%)
		Ubl_USP48	958..1053	CDD:340493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810