Protein Alignment puf and Usp9y

DIOPT Version :10

• Sequence 1: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Sequence 2: NP_683745.2
• Gene: Usp9y / 107868
• MGIID: 1313274
• Length: 2556
• Species: Mus musculus
• Alignment Length: 3235
• Identity: 598/3235 - (18%)
• Similarity: 1011/3235 - (31%)
• Gaps: 1268/3235 - (39%)

  Fly    99 AQAQQQREQQRDEASAQAEAKESSAPAEEPKKEEPSGSAGEEAQGSGDGPAKKPPVGPCTPPPPQ 163
            :..|.|...|:::.|:...:.|:| |...|.:           ||.||.|
Mouse    20 SDGQPQPSFQQNQISSSDSSNETS-PTTPPYE-----------QGQGDAP--------------- 57

  Fly   164 TANPQHKSHLQYTEEP------------------WILP-----EVEKLL---------------- 189
               |||:.     |:|                  |::|     |:|.||
Mouse    58 ---PQHEE-----EDPSFPHTDLAKLEDMINRSRWVVPVLPKGELEVLLEASIDLTKKGLDVKSE 114

  Fly   190 -----------VLVSKVF---------------LLN-----------------FP----LYIA-- 205
                       |..||:.               ::|                 ||    |.||
Mouse   115 ACQRFFRDVLTVSFSKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPFLELLAIALN 179

  Fly   206 -----HKHG----MHSRLDDLQAEEAHHLALICDLHDNDLPI-YLLRNVSLFCNSGGFGAMSLCF 260
                 |.:.    ..|....:|..|....|...|||.   |. :|:..::.|....||..:...|
Mouse   180 PHCKFHVYNGARPCESVSSSVQFPEDELFACSPDLHS---PKGWLVDLINTFGTLNGFQILHDRF 241

  Fly   261 EHPD-LPVSTAHSMTAAVSNVKLWLNYHCNTQLFVPLRSRILQYMCKLSDQSLRSAATRAMADFV 324
            .... |.|.|..::.........:|..|...:.|:|:...:.|.:.||:::.|:......:.:
Mouse   242 TSGSALNVQTIAALIKPFGQCYEFLTQHTLRKYFIPVIEVVPQILQKLTNEELKKETKTEVKN-- 304

  Fly   325 WSSMRDPLDVAVNFDTEGLALAFKYFTSTT---------LTMRLAGMAQINAHINLFNEICTTET 380
                 |.:.:.:.| .:.||........|.         :.:||..::..|..:|..|||  .:.
Mouse   305 -----DTISMIIKF-LKNLASRIPGQEETVKNLETFRLKMILRLLQISSFNGKMNALNEI--NKV 361

  Fly   381 VNEVELFG-------------QRIANWLTENHIVQHLFGPNLH-VEIVKQAHVLLNFLAVENQIS 431
            ::.|..:.             :|:..|:.:|:|:..:...:|| .:.|::...:|.|:..|..::
Mouse   362 LSSVSYYTHGHGNSEEEWLTVERMTEWIQQNNILSIVLQDSLHQPQYVEKIEKILRFVIKEKALT 426

  Fly   432 EEDIKLIWQATQLKH--CSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALT 494
            .:|:..||.|...||  ..|.:.|:|..|..|.:|....||:...
Mouse   427 LQDLNNIWAAQAGKHEAIVKNVHDLLAKLAWNFSPEQLDHLFDCF-------------------- 471

  Fly   495 KQLWTRDTSRSQMNLMQDHLLGSNVTASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKS 559
            |..||..:.:.:..|::                 :.....|||.
Mouse   472 KASWTNASKKQREKLLE-----------------LIRRLAEDDK--------------------- 498

  Fly   560 PIDGVTPCKQARHRRHICDPTTEKGKQISPEDMAKVDLVNKRIVNIIDNTSSEEELQSRAALELQ 624
              |||                           ||      .:::|::.|.:..::
Mouse   499 --DGV---------------------------MA------HKVLNLLWNLAHSDD---------- 518

  Fly   625 LHRSRKKTSNKRRRQKTNKQIILPHELVEIWDGVEDVPSSDEADGEADGDGEGELLADSDECSDG 689
                                  :|.:::::                        .|:...:..|.
Mouse   519 ----------------------VPVDIMDL------------------------ALSAHIKILDY 537

  Fly   690 ATSQLVPDAVLKHLQGEGPFIRAIETNINELLSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCE 754
            :.||   |...:.:|....||....||                   ||.           |.|..
Mouse   538 SCSQ---DRDTQKIQWIDCFIEEFRTN-------------------NKW-----------VIPAL 569

  Fly   755 EELAQLVSSRANCSDVPPAFAAAAAAMMVAQSAMALQKSGESNVAAAAAAVAAAAAATGTAQQTL 819
            :::.::      ||                                          ..|.|.|.|
Mouse   570 KQIKEI------CS------------------------------------------LFGEAPQNL 586

  Fly   820 VAMNRQASVAAAAAVVAAAKAKSDSDVDLMDVVSGGKQHHSPKASQGSSTSGSTPVQPSFKLNDV 884
                                               .:.|.||:.
Mouse   587 -----------------------------------SQTHQSPRV--------------------- 595

  Fly   885 CQPGNTLLWDLLQDDKIGQLGESLALEAEKALATLLCFSMDRQLRTKFIEGCLYNVANNRSVIVS 949
                      ..:.|.|.|      |:...||.||                    ||.|
Mouse   596 ----------FYRHDLISQ------LQHNHALVTL--------------------VAEN------ 618

  Fly   950 LRLLPKLFASFQQFRPSDTHSMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQNGEQQQQQLGG 1014
                                            :..:.|:||.|||.|      ::.:.|..:||.
Mouse   619 --------------------------------LAAYMNSIRLYARDH------EDYDPQTVRLGS 645

  Fly  1015 QLYSHKTQVSVRLQFLSSIFSTVGSPKSFRLTLEQLDALWEWLAH------DPECADCYFSWLQA 1073
            : |||..:|..||.||..:.    ......|.:.|...:|..||.      |.|....::|.|.
Mouse   646 R-YSHVQEVQERLNFLRFLL----KDGQLWLCVSQAKQIWNCLAENAVYFSDREACFMWYSKLM- 704

  Fly  1074 QAKGGDQHALGIEALQHLYLKKLPELRPEEFSMVALGLFQQL-----CSFARIAMAEYDNHSDQI 1133
                ||:..|..:..:..:...:.:|.|...:...:..|::.     |...::.:.......|.:
Mouse   705 ----GDEPDLHPDINKEFFESNVLQLDPSLLTENGMKCFERFFKTVNCREGKLMIKRKIYMMDDL 765

  Fly  1134 SASASAVGMYHLWKIALRAQSN-DVSLAAIQYINMYY--MGQQLR-----LEKEFVSQCMENLVQ 1190
                ..:|:.:|||:.:  ||| |:|..||..:...|  :|.:|:     :.::|:..|.:.|..
Mouse   766 ----DLIGLDYLWKVVI--QSNDDISSRAIDLLKEIYTSLGPKLQANQVVIHEDFIQSCFDRLKA 824

  Fly  1191 AATALESIDDE---------NALMRVQRGLLLLNTHLDTFRRRYAFHLRRW------AIEGKGIG 1240
            :...|..:|.|         ...:|:.|.|.:|..::..:...|  |..|.      |..||.:.
Mouse   825 SYDTLCVLDSEKDNIFSCARQEAIRMVRILTVLREYISEYDSDY--HEERMILPMSRAFRGKHLS 887

  Fly  1241 SHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSK----WWESLQTGLAAPVLG 1301
            ......|:|.                   ::...|:::...|.:..    ....:...:|...:.
Mouse   888 FTVRFPNQGK-------------------EVEDLDILSHTNATIGSVRRCILNRMNVNVAHTKIE 933

  Fly  1302 LLLSDGPLRIITQGQELTSDYDERSLGD-AGFKDNQIV---YVSLGGR-------------GARR 1349
            |.:          |.||.:..|:|.|.: ...||..::   ::.:...             |...
Mouse   934 LFI----------GGELVASEDDRKLVEQLNLKDKSLITAKFIQINSNMPSSPDSSSDSSAGPPG 988

  Fly  1350 KESNLEHPSMLPPPPKECLPTVLL-LQPKYFEKLFCLMQTLGDMQPQASTVNPQHHTKAQLLSRR 1413
            ..|:..:..:..|..::|||.|:: |||:|...|:                             :
Mouse   989 NHSHNNYRDVSNPEMEKCLPGVIMSLQPRYISFLW-----------------------------Q 1024

  Fly  1414 VWDILAMLPTNPHILDA----FKSLVTDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQ 1474
            |.|:.:|| |.|.:.|.    .|.:..|.:.||||.|
Mouse  1025 VADLGSML-TVPTLRDGARILMKLMPPDSTTLEQLRA---------------------------- 1060

  Fly  1475 KFMYSLHIVESLALTSSRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQ 1539
              :.|.|:    .|...|.|:|..::..|::..||.                            .
Mouse  1061 --LCSDHV----NLGERRLGQSLHSLFFGSSASQVL----------------------------Y 1091

  Fly  1540 LCELEAPLTPTPSTGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPT 1604
            |.|:...|.......|.|:.::                         |:..
Mouse  1092 LTEVVYTLLMPAGAPLADISSD-------------------------FQYH-------------- 1117

  Fly  1605 PPPPALSVVERGDNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKELALNEWRHDCLASLLRI-- 1667
                               |:|.|||..:..:.    :|.:..|....  |.|.|...|.|:|
Mouse  1118 -------------------FLKSGGLPLVLSML----IQNNFLPNTDV--ETRRDAYFSALKIAK 1157

  Fly  1668 --LWLLGFEELQS--------ADA-------------------HVLMSRPHPFMLQLMEVPQCLT 1703
              |.::|:..:|:        ||.                   :.|.|.|:|       ..:|:.
Mouse  1158 LLLTIVGYGHVQAIAEACQPVADGTDPKTPINQVTHDQAVVLQNALQSIPNP-------SSECML 1215

  Fly  1704 RLSSILNDEVHQQHQASSANPLVFP--YQFQHLRTGFW----GRAQLI---------QFAM---- 1749
            |     |..||...|.|.......|  ...:.::...|    |..:|:         .:.|
Mouse  1216 R-----NVSVHLAQQISGLASRYIPDICVIRAIQKIIWAAGCGSLELVFSPNEDITETYKMTTST 1275

  Fly  1750 --NILVSFVHASAEARRLL-----WAPTGTDHCR----WLQKFILE----DPEPAVRR------- 1792
              |:.|.......||..::     ..||..|...    | |.|:::    .|...||:
Mouse  1276 RSNLEVKDEQVCCEALEVMTLCFALIPTAMDSLNKEKAW-QSFVIDLLLYCPSKTVRQLAQEQFF 1339

  Fly  1793 EICAGLYRICLGNAHSYRLLLAPLLHKLIALLPLAEQMSSGNQHTQFLLSEEGKDPYGPACRD-Y 1856
            .||.   |.|:|:        .|||..:..|..:....:          :|:||.      .| |
Mouse  1340 LICT---RCCMGH--------RPLLFFITLLFTILGGAA----------NEKGKH------SDVY 1377

  Fly  1857 FWLLARLVDTLSPEMVAEEHIDIEMLCESISQSILTREYYEL--RHGYQDDGLVGLLNLMSNLIK 1919
            |.||.||:.......:...::|: :|.:.|......|:|.:.  ....:|..|.|.|.:...|:.
Mouse  1378 FTLLRRLLTYAYNSNIQVPNVDV-LLNDEIDWLKRVRDYIKNTGETNVEDPILEGHLGVTKELLS 1441

  Fly  1920 YDTTFK-----YTPKALSFIEQLIGFLFDMPS-------------PADRQKPKCKSASSRASAYD 1966
            :.:..|     ......:.:::||.: |..|:             |..:..|.|.|.::..:.::
Mouse  1442 FQSPEKKYHIGCKTGGANLVKELIDY-FIFPASKAYLQYMRSGELPIKQAIPVCGSPATINAGFE 1505

  Fly  1967 LLVELCRGCATNYAYLHGRLLAQHKSGP-----KQPYPWDYWPRDEGRAECGYVGLTNLGATCYM 2026
            |||.|..||..|...:...|......|.     :....|:|.|....|...|:|||.|.||||||
Mouse  1506 LLVALAFGCVRNLKQIVNCLTELFYIGTPVTTCEAVGEWEYLPPVGPRPPKGFVGLKNAGATCYM 1570

  Fly  2027 ASCVQHLYMMPQARAAVL--------------------------------RVPPNAARKHGPTLL 2059
            .|.:|.|||:|..|.::|                                |.|.....|  |||.
Mouse  1571 NSVIQQLYMIPSIRNSILAIDSIWSDTDDDIFKGEKQDSENNVDPRDDVFRYPHQFEDK--PTLS 1633

  Fly  2060 E--------------LQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSK 2110
            :              ||..|.:|..|:.:.|.|:.|.:.:::..:|:|..||.|..|||..||..
Mouse  1634 KVEDRKEYNIAVLKHLQITFGHLAASQLQYYVPKGFWQQFRLWGEPVNLREQHDALEFFNSLVDS 1698

  Fly  2111 LEDMTPDLKH--LVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKD 2173
            |::....|.:  ::.::..||.::..:...|.|.....|.|.|:...:.:.:||.:||::....|
Mouse  1699 LDEAFKALGYPTVLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGD 1763

  Fly  2174 TLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCH 2238
            .|||.|.|.|.:|.|||...||...||||.:|.....|:.::.......|.|.:|.||..|:|..
Mouse  1764 LLEGANAYHCEKCDKKVDTVKRLLIKKLPSVLTIQLKRFDYDWERECAIKFNDYFEFPRELDMEP 1828

  Fly  2239 YVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADG 2303
            |........:......:.|..|:          ||::|:.:....    :|.||||.||:|.|:|
Mouse  1829 YTVAGATKLEGDSVNPQTQLIKQ----------NEQSESVIPGST----KYRLVGVLVHSGQANG 1879

  Fly  2304 GHYYSFIKERT-KTSYHTHERWFLFNDAEV---KPFDPSQIAAECFGGEMTSKTYDSVTEKYLDF 2364
            |||||:|.:|. |.|..:|  ||.|:|.:|   |..|..::..:|||||...:.:|.:.::   .
Mouse  1880 GHYYSYIIQRNGKDSKRSH--WFKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKR---M 1939

  Fly  2365 SFEKTN---SAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSSEIKADVD 2426
            |:.:..   :||:|||||                                             :|
Mouse  1940 SYRRQKRWWNAYILFYER---------------------------------------------MD 1959

  Fly  2427 VEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEKPTEMT 2491
            :                                                       |||....:|
Mouse  1960 I-------------------------------------------------------TDEDDEIIT 1969

  Fly  2492 TVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRP--LLNKELEDWIWQDNRQ 2554
            .:|                                     :|...||  :::..:|..:|:.|.|
Mouse  1970 YIS-------------------------------------ELTFTRPHQIMSPAIERSVWKQNVQ 1997

  Fly  2555 FLQDRNIFEHTYFNFMWQI--CGHIPQS-------LISET-DVTCMAAKLSVSFFIETFIHAKE- 2608
            ||.::..|...||.|:.::  |..:..|       |:.|. |:|.::.:|:..|...|..|.|:
Mouse  1998 FLHNQMQFSLEYFQFIKKLLTCNAVYLSPAPGQDHLLPEAEDITMISIQLASRFLFTTGFHTKKI 2062

  Fly  2609 -KPTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPV-----QVLIQCPNQMVRQMFQRLVIHV 2667
             :.....|.:.|......|:....||:.::    .:.|     :.|::||:..:|..|.:|::.:
Mouse  2063 IRGPANDWYDALCILLRHSKNVRFWFVHNV----LFNVSNRFSEYLLECPSAEIRGTFAKLIVFI 2123

  Fly  2668 IQQLRASHAHLYLEVETDEDD-----------KELIGQASCVTRFIGSLISLL-----EHGARAN 2716
                    ||..|:..:....           .::....|.....:.:::|||     |||
Mouse  2124 --------AHFSLQDGSSPSPFTSPFANPGPYSQIYDNLSLSDHLLKAVLSLLRREVSEHG---- 2176

  Fly  2717 LRHLSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDNSSEEALSVE 2781
             |||.:||.|...::.:|..|...||::.|..:   |.|         :|.|.......:....|
Mouse  2177 -RHLQQYFNLFIMYASLGLAEKTQLLKLNVPAT---FML---------VSLDEGPGPPVKYQYAE 2228

  Fly  2782 KMRPASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGINPHQTKHLIH 2846
            ..:..|:...:..|.|:..|.:             |:|.|....|          ||....:|..
Mouse  2229 LSKLHSVVSQLIRCCSVSSRMQ-------------SSINGNPPLP----------NPFGDPNLSQ 2270

  Fly  2847 ALCRWDERLATQIIGMLFASVTKHTELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEY 2911
            .:....:.:| .|:.|....:.|..|.|:.....:.||         |.|        .|:..::
Mouse  2271 PIMPIQQNVA-DILFMRTTYMKKVIEDCSNSEDTVKLL---------LFC--------CWENPQF 2317

  Fly  2912 -CPQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDN---TRVRNA 2957
             |  |||..|..|...   :||:.||.....|.|.:|..|:   .|:.||
Mouse  2318 SC--SVLSELLWQVAH---SHAYELQPYLDLLLQIILFEDSWQAHRIHNA 2362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	129/423 (30%)
		DUF3517	2648..>2884	CDD:463438	49/251 (20%)
		MDN1	<3661..>3887	CDD:444083
Usp9y	NP_683745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		18/82 (22%)
		Ubl1_cv_Nsp3_N-like	<900..964	CDD:475130	12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..999		2/27 (7%)
		peptidase_C19C	1557..1960	CDD:239124	129/468 (28%)
		DUF3517	2097..2457	CDD:463438	71/337 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2513..2556