DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment puf and usp24

DIOPT Version :10

Sequence 1:NP_001262923.1 Gene:puf / 42935 FlyBaseID:FBgn0039214 Length:3930 Species:Drosophila melanogaster
Sequence 2:XP_002931653.2 Gene:usp24 / 100497137 XenbaseID:XB-GENE-6035156 Length:2577 Species:Xenopus tropicalis


Alignment Length:2891 Identity:615/2891 - (21%)
Similarity:1052/2891 - (36%) Gaps:753/2891 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 KYFTSTTLTMRLAGMAQINAHINLFNEICTTETVNEVELFGQRIANWLTENHIVQHLFG-----P 407
            |...::|...:| |::..:.:...|.:.|..|...:: |....:..|.||.|  :.::.     .
 Frog   130 KCLIASTYLAKL-GISDSDENCKRFMDRCMPEAFKKL-LTSSAVHKWGTEIH--EGIYNMLMLLV 190

  Fly   408 NLHVEIVKQAHVLLNFLAVENQISEEDIKLIWQATQLKHCSKTIFDILPSLVKNLTPRPAMHLYS 472
            :|..|.:||..:....|.|.......|.:..:: .::|.|.|...|:.                 
 Frog   191 DLVAERIKQETIPTGLLGVLTMAFNPDNEYHFK-NRMKACQKNWSDVF----------------- 237

  Fly   473 LLCRMDPKEHTEQSIYIASALTKQL--WTRDTSRSQMNLMQDHLLGSNVTASSSDSGSIEGSNTE 535
                   .|....::...|::.|:.  |..|.    :|...:  ||......|.       .|:|
 Frog   238 -------GEGNTYAVSPPSSMQKEPHGWLVDL----VNRFGE--LGGFSAIQSK-------LNSE 282

  Fly   536 DDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRRHICDPTTEK--GKQIS-PEDMAKVDL 597
            |..:||..:.:...|......|.|.:                .|..::  .|.|. .:.:.:.||
 Frog   283 DIELGAVSALVQPLGVCAEYLNSSTV----------------QPMLDRVIHKMIKYVQSVEEKDL 331

  Fly   598 VNKRIVNIIDNTSSEEELQSR-------AALELQLHRSRKKTSNKRRRQKTNKQIILPHELVEIW 655
            .:||:|:|.:..|:.:.|..|       |..:|:|....:...:.....|.|       .|.|:.
 Frog   332 KDKRLVSIPELLSAIKLLCMRFQPDLVTAVDDLRLDILLRMLKSPHFSAKMN-------SLKEVT 389

  Fly   656 DGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQLVPDAVLKHLQGEGPFIRAIETNINEL 720
            ..:||...|.......|              :|.....||.::||.         .|:|.||:: 
 Frog   390 KLIEDSTLSKSVKNAID--------------TDRLLDWLVENSVLS---------IALEGNIDQ- 430

  Fly   721 LSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCSDVPPAFAAAAAAMMVAQ 785
                                  |.:.|.     .:.:.:|:.|:.:..::               
 Frog   431 ----------------------AQYCDR-----IKGIIELLGSKLSLDEL--------------- 453

  Fly   786 SAMALQKSGESNVAAAAAAVAAAAAATGTAQQTLVAMNRQASVAAAAAVVAAAKAKSDSDVDLMD 850
            |.:...:||:|:.                     |..|....:||     ||.|..||....|..
 Frog   454 SKIWKIQSGQSST---------------------VIENIHTIIAA-----AAVKFNSDQLSHLFV 492

  Fly   851 VVSGGKQHHSPKASQ---------GSSTSGSTPVQPSFKLNDVCQPGNTLLWDLLQDDKIGQLGE 906
            ::....::.|.:..|         |......|   .:.|:.:|       ||:|..   :..|..
 Frog   493 LIQKCWENESDRVRQKLLSLIGRIGREARNET---TTAKVLEV-------LWELAH---LPALPS 544

  Fly   907 SLALEAEKALATLLC--FSMDRQLRTKFIEGCLYNVA-----NNRS---VIVSLRLLPKLFASF- 960
            ||..:|.....|:||  :::...::..:|..|:.::.     ||..   |:.:||.|.::..|| 
 Frog   545 SLIQQALDEHLTILCDAYAVKETIKRSYIIKCIEDIKKSSQHNNPQVVWVVPALRQLHEITRSFN 609

  Fly   961 -QQFRPSDTHSMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQNGEQQQQQLGGQLYSHKTQVS 1024
             |.::..| .|:....::|..:::....:: ....|.|...:...|......:.|: |:::..:.
 Frog   610 KQTYQKQD-KSIIQDLKKNFEIVKLVTASL-VACHRLAVNAVGPGGLFGSTLVDGR-YTYREYLE 671

  Fly  1025 VRLQFLSSIFSTVGSPKSFRLTLEQLDALWEWL--AHDPEC---ADCYFSWLQAQAKGGDQHALG 1084
            ..|:||:......    :..|...:...:||.|  .|| .|   .:..|.|.   .||  ||.|.
 Frog   672 AHLKFLAFFLQEA----TLYLGWSRAKEIWECLVTGHD-VCELDREMCFEWF---TKG--QHDLE 726

  Fly  1085 IEALQHLYLKKLPELRPEEFSMVALGLFQQLCSFARIAMAEY---DNHSDQISASASAVGMYHLW 1146
            .:..|.|:.:|:.:|...|.:|....||:..  |..:.:.::   ...:..:......:||..:|
 Frog   727 SDVQQQLFKEKILKLESYEITMNGFNLFKTF--FENVNLCDHRLKRQGTQLLVEKLELIGMDFIW 789

  Fly  1147 KIALRAQSNDVSLAAIQ-YINMYYMGQQLRLEKE-------FVSQCMENLVQA------------ 1191
            |||:.:...:::..||| .||..|:....||:|:       |::.|...|..|            
 Frog   790 KIAVESPDEEIANEAIQLIINYSYINLNPRLKKDSVPLHKKFIADCYTRLEAASSALGGPTLTHA 854

  Fly  1192 ----------------ATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEGKGIG 1240
                            ||:::|......|:.::|.|||...::.|....|:...   .|...|..
 Frog   855 VTRATKMLTATAMPSVATSVQSPYRSTKLVIIERLLLLAERYVITIEDLYSVPR---TILPHGAS 916

  Fly  1241 SHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESLQTGLAAPVLGLLLS 1305
            .|.:|        |.:.|......:...|:.|:.:.|..::.::::       .|..||..    
 Frog   917 FHGHL--------LTLNLTYESTKDTFSLEAHSNETIGSVRWKIAR-------HLNCPVEN---- 962

  Fly  1306 DGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYV-SLGG-----------------RGARRKES 1352
               ::|......||.:.|::.|...||.|.|.:.| :|||                 .|......
 Frog   963 ---VQIFANESLLTVNKDQKLLHQLGFSDEQALTVKTLGGGTPSGSSTDASCSSGTSSGVFSSSY 1024

  Fly  1353 NLEHPSMLPPPPKECLPTVLLLQPKYFEKLFCLMQTLGDMQPQASTVNPQHHTKAQLLSRRVWDI 1417
            .::....||       ..|:.|....|:.|:    .|.:::....||             ||..:
 Frog  1025 AMDQEKSLP-------GVVMALVCNVFDMLY----QLANLEEPRITV-------------RVRKL 1065

  Fly  1418 LAMLPTNPHILDAFKSLVTDLSELEQLDAGGEEEQL--------ATKRKQIKQK----------- 1463
            |.::||:|.:.:|          |:|||:.|.:..|        ::|...:..|           
 Frog  1066 LLLIPTDPAVQEA----------LDQLDSLGRKNTLLSETQASQSSKSPSLSSKQHHQPSASSIL 1120

  Fly  1464 ---FRDLLDPNNLQKFMYSLHIVESLALTSSRRGESNGNVAMGNTPEQVRVKKSSM---GRRRNS 1522
               ||......:..:.:|:|.::.| .|..:...|...|.|.......::....|:   ..:|:|
 Frog  1121 ESLFRSSAPGMSTFRVLYNLEVLSS-KLMPTADDEMARNCAKSFCENFLKAGGLSLVVNVMQRDS 1184

  Fly  1523 NEQPPPPPPEVKMSKEQ----LC-ELEAPL---TPTPSTGLQDVETEA-SSSSGGDKENQPKQHS 1578
                  .|.||.....|    :| :|...|   ...|:|..:|:..:. .|.|.....|..:|.|
 Frog  1185 ------IPSEVDYETRQGVYSICLQLARFLLVGQTMPATLDEDLNKDGIESLSSRPFRNAGRQSS 1243

  Fly  1579 KRQKKGETFEQEKERPVGCSTPPSPTPPPPALSVVERGDNKWSEAFVKCGGLRHLYEIFSEGQLQ 1643
            ::...             |.||...:  ...|||.:|...:             :.||....::.
 Frog  1244 RQMSL-------------CGTPEKSS--YRQLSVSDRSSIR-------------VEEIIPAARVA 1280

  Fly  1644 QSAHPKELALNEWRHDC-LASLLRILWLLGFEELQSADAHVLMSRPHPFMLQLMEVPQCL-TRLS 1706
                .:.:.:|::  .| :|..:|:.|......|.      |:....|........|..| :|||
 Frog  1281 ----IQTMEVNDF--TCTVACFMRLSWAAAAGRLD------LVGSNQPIKESNTLFPAGLRSRLS 1333

  Fly  1707 SI-LNDEVHQQHQASSANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLW-AP 1769
            |. .|.....:.:::|.:..:...| |.:.|   ..|.:...|:::||:.:...::.....: .|
 Frog  1334 SSGSNCSSGSEGESTSLHAWICVRQ-QSVST---KDAIIAGEALSLLVTCLQLRSQQLGSFYNLP 1394

  Fly  1770 TGTDHCRWLQKFILEDPEPAVRREICAGLYRICLGNAHSYRLLLAPLLHKLI----ALLPLAEQM 1830
            :..|   :....:|..|...:||..|..||.:...:..||..:..|.|..|.    |.|||....
 Frog  1395 SVAD---FTIDILLGSPSAEIRRVACDQLYTLSQTDTSSYPEVQKPNLFLLTVILSAQLPLWSPT 1456

  Fly  1831 SSGNQHTQFLLSEEGKDPYGPACRDYFWLLARLVDTLS-PEMVAEEHIDIE---MLCESIS--QS 1889
            |......|.||::         |.:||.|..:|:|.|: .||   |.:::.   ||.:.|:  .:
 Frog  1457 SIMRGINQRLLAQ---------CTEYFDLRCQLLDDLTCSEM---EQLNVSPATMLEDEITWLDN 1509

  Fly  1890 ILTREYYELRHGYQDD-GLVGLLNLMSNLIKYDTTFKYTPKAL--SFIEQLI-GFLF-------D 1943
            .......|......|: .|.|.|.|:..|:......|   :.|  |.|:||: .|||       :
 Frog  1510 FEPNRTAECETSEADNVWLAGHLRLIKTLLSLCGAEK---EMLGPSLIKQLLDDFLFRASRIILN 1571

  Fly  1944 MPSPADRQ-------KPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYP-- 1999
            ..|||...       .|||.:.:||.:||::||.|......|...:...||:.|    .||.|  
 Frog  1572 SHSPAGSAAISQQDFHPKCSTMNSRLAAYEVLVMLAESSLANLQLITKELLSMH----HQPDPAV 1632

  Fly  2000 ---WDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLEL 2061
               :||.|..:.|:..|:|||.|.||||||.:..|.|||.|....|:|.:..:..........::
 Frog  1633 TKEFDYLPPVDSRSNSGFVGLKNGGATCYMNAVFQQLYMQPGLPEALLSMEGDTDNPDESVFYQV 1697

  Fly  2062 QRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDL--KHLVKR 2124
            |.:|.:|:||:.:.|.|.:|.::::|.::.|...||:|..|||..|:.::::....:  :.:.|.
 Frog  1698 QSLFGHLMESKLQYYIPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGREQIFKN 1762

  Fly  2125 LFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKK 2189
            .|.|..|:..:..||.|.....|.|..:...|...::|:.|||:....:.|||.|.|.|.:|..|
 Frog  1763 TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEILEGSNAYYCEKCKDK 1827

  Fly  2190 VRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERE 2254
            ....||.|.|.||.:|..:.||:.|:..:....|.:....||..|||..|....:..|....|  
 Frog  1828 RTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIKFPWMLNMEPYTVAGMARQDSSCE-- 1890

  Fly  2255 RRQKEKEGADG----SGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTK 2315
                  .|.:|    .|.|:..:|...|        ..||||||.||:|.|..||||||||:|..
 Frog  1891 ------AGENGRHIDPGGGSPRKKVAPT--------ENYELVGVIVHSGQAHAGHYYSFIKDRRG 1941

  Fly  2316 TSYHTHERWFLFNDAEVKPFD--PSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYE 2378
            :.   ..:|:.|||..|:.||  ...|..||||||...|.||. :..|.|......| ||||||:
 Frog  1942 SG---KGKWYKFNDTVVEEFDLNDETIEYECFGGEYRPKVYDQ-SNPYPDVRRRYWN-AYMLFYQ 2001

  Fly  2379 RRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTD 2443
            |              |:...||.:.:||....                |..|.|:.....|:..|
 Frog  2002 R--------------VSDQNSPVLPKKSRVSV----------------VRQEAEDLSLSAPSSPD 2036

  Fly  2444 TESKETPAKEEIADDKSKQDEPEEKK--IEKQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCD 2506
            ...:.:|          :...|.::.  :.|..|:||:|.                         
 Frog  2037 ISPQSSP----------RPHRPNDRLSILTKLVRKGEKKG------------------------- 2066

  Fly  2507 NHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELEDWIWQDNRQFLQDRNIFEHTYFNFMW 2571
                                        ||...:...:...:..:|.:|:::|:::...||:|:.
 Frog  2067 ----------------------------LFVEKIPLRIYQTVRDENLKFMKNRDVYNSDYFSFVL 2103

  Fly  2572 QICG----------HIPQSLISETDVTCMAAKLSVSFFIETFIHAKEKPTM--VPWVELLTKQFN 2624
            .:..          :.|.:.:|        |:|::.|...|::..|.|..:  ..|:..:....:
 Frog  2104 SLASVNATKLKHPLYQPMAKVS--------AQLAIQFLFHTYLRTKRKLRVDTEEWIATIDALVS 2160

  Fly  2625 ASQEACEWFLSHMSQEPYWPVQVLIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETD---- 2685
            .|.|||:|.:.:           .:....:.:.::|  |:...|:::||:.|.: ||...|    
 Frog  2161 KSCEACQWLMEY-----------FVCSEGKELVKIF--LLESSIREVRAAVATI-LEKTLDAALF 2211

  Fly  2686 EDDKELIGQASCVTRFIGSLISLLEHGARANLRHLSEYFGLLCEF-SRMGDEEAMYLLRIGVLKS 2749
            ..||     .:.|...|..|:||||.....:.::.::||.|...| .:.|......|||...||.
 Frog  2212 HGDK-----VNGVHLLIEMLLSLLEKDVPESCKNCAQYFYLFSNFVQKQGSRAVDLLLRYSALKH 2271

  Fly  2750 LVDFYLGHKQTDSIDISSDNEDNSSEEALSVEKMRP-ASLDKMIALCASLVERSRGADFRLRLSP 2813
            .::|.||           .|..|:.....|..:.|. ..|...|||   ||..|           
 Frog  2272 FINFLLG-----------PNRQNNQNRRWSSPQAREFGYLHSTIAL---LVLYS----------- 2311

  Fly  2814 KDFSAIAGGKGFPFLYQQIKDGI-NPHQTKH------LIHALCRWDERLATQIIGMLFASVTKHT 2871
             |.|:          ::.:..|: .||.:.:      |:||          ::..::|....|  
 Frog  2312 -DVSS----------HRTVAPGVFKPHPSTNTCGSPLLLHA----------EVEALMFMPEGK-- 2353

  Fly  2872 ELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEYC-------PQSVLDWLSLQATKNKI 2929
                |:  ||.::...:..|..|....::::        ||       ..::|.::     ||: 
 Frog  2354 ----PY--LLEVMFALRELPGSLTVLIEMVV--------YCCFCNERFSLTLLHFI-----KNQ- 2398

  Fly  2930 AHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPFRANFRAHSQHKLLALNPHSYRDI 2994
                 |::|.        .|:...|......:||...|.|..|..|...|. .||||..||....
 Frog  2399 -----LETAP--------PHELKNVFTLLYEILVIEDPLQLQRLKFTFESD-GLLALMHHSNHVD 2449

  Fly  2995 NSDAQAVLHQVITLLLRLLRPARVYADIGAH 3025
            :|.....:..::||..:.......:.|...|
 Frog  2450 SSRCYQCVKFLVTLAQKCPAAKEYFKDNSHH 2480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pufNP_001262923.1 peptidase_C19C 2013..2382 CDD:239124 128/376 (34%)
DUF3517 2648..>2884 CDD:463438 55/248 (22%)
MDN1 <3661..>3887 CDD:444083
usp24XP_002931653.2 UBA_UBP24 6..42 CDD:270472
Ubl_UBP24 917..995 CDD:340585 19/99 (19%)
peptidase_C19C 1649..2005 CDD:239124 129/390 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.