DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and usp28

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_002937867.3	Gene:	usp28 / 100492386	XenbaseID:	XB-GENE-990711	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	189/974 - (19%)
Similarity:	320/974 - (32%)	Gaps:	336/974 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2003 WPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAV----------LRVPPNAARKHGPT 2057
            ||          |||.|:|.||:.::.:|.|:.:|:.|..|          .:......:::...
Frog   136 WP----------VGLKNIGNTCWFSAVIQSLFHLPEFRRLVHSYSITQSMLEKCQSRDEKRNLAF 190

  Fly  2058 LLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLED---MTPD-- 2117
            :.|||.:|..::.|.||..:|.....:.: |.......:|:|::||...|:..|||   :|.:
Frog   191 MQELQCLFTLMVGSNRKFVDPSPALELLK-DAFLSEEAQQQDVSEFTHKLLDWLEDAFQLTVNGE 254

  Fly  2118 -----LKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEG 2177
                 .::.:.:||.|:..|... |:........|.|.....||....||.|.|:...|:..:|
Frog   255 DPRDKSENPMVQLFYGTFLNEGF-LEANKAFSNIETFGQYPLQVNGFSNLNECLEAAMVEGEIE- 317

  Fly  2178 DNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFP--LRLNMCHYV 2240
             ||    |..:..|..:...|.|||.:|.|...|:.||......||::....||  :.::...|.
Frog   318 -NM----QTAQSARYRQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPEIIYMDRFMYK 377

  Fly  2241 EKTLMPQQYKEERERR------------------------------------------------- 2256
            .|.||.:::.|.|..:
Frog   378 NKELMRRKHSETRRLKGCIDHLNQKLESYLKYGSGPNRCPLPDMLQYVLEFANTKSAEWCPPTEV 442

  Fly  2257 ---QKEKEGADGSGD---------GN--------DNEKAEAT----------------------- 2278
               .:...|:.||.|         ||        |:.|.|:|
Frog   443 VTTSQSATGSTGSLDAQPLQNGFVGNNDTETSNDDSPKCESTSSLPPFVGHTVPNDCIPAEDPTH 507

  Fly  2279 ----------------------------LDDDIEECYE---------------YELVGVTVHTGT 2300
                                        |.|.|..|.:               |.|..|.||.|.
Frog   508 GSDTLEEIRSVAACLQRWRTEVEKDIQDLKDSIASCTKSIEEVFIDQDLSQVPYRLHAVLVHEGQ 572

  Fly  2301 ADGGHYYSFIKERTKTSYHTHER--WFLFNDAEVKPFDPSQIAAECFGGEMTSKTY--------- 2354
            |:.|||:::|        ::|.|  |..:||..|...:..::..:.:||...:..|
Frog   573 ANAGHYWAYI--------YSHSRCCWLKYNDVSVTEANWEELVRDSYGGMRNASAYCLMYINNKL 629

  Fly  2355 ------------DS-----------VTEKYLDFSFEKT--------------------------- 2369
                        |.           |.|....|..|.|
Frog   630 PYLIADHEGELEDKINALHPALQCYVQEDNQRFDQEMTEWEEAHSCKIPQIESVGSSESVDHPSR 694

  Fly  2370 NSAYMLFYE--RRL-PEH--LQRRHSELLVTPTPSPTVEEKSEA--EEPTKMETSSSEIKADVDV 2427
            |:|.:...|  |.| .||  :.:..:.|.:|.|.........|.  :||||.||..:.:.   |.
Frog   695 NNASLCCEECSRSLSSEHAMIAKEQTALAITKTAESYERNGVEVALKEPTKPETGEASLS---DA 756

  Fly  2428 EVEVEEKDKEKPA----------------QTDT-----ESKETPAKEEI--ADDKSKQ----DEP 2465
            .:..:|:.:.:|:                :|||     |....||.:.:  |..|::|    |.|
Frog   757 SLTAQEETEPQPSSQLSEVEIPSVGKILVRTDTDGYNEEMMLCPAMQGVIFAILKARQVFDRDGP 821

  Fly  2466 EEKKI----EKQSR----EGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKAS-ND 2521
            |...:    |:.||    ..||.|.:.:...:...:...:.|.|....:.......::...| |:
Frog   822 EAGLVKAFHEEYSRLYQLSKEEPSPSSDPRLQHVLIYFFQNKAPDRVIERTLLEQFADKNLSYNE 886

  Fly  2522 QQPSTSKAAQ-KLQLFRPLLNKELEDWIWQDNRQFLQDRNIFE----------HTYFNFMWQ--- 2572
            :..|..|.|| ||:...|      :|...::.:::.:|.::|.          ..|.|..||
Frog   887 RSISIMKVAQAKLREIGP------DDMDMKEYQKWHEDYSLFRKVSVYLLTGLELYQNEKWQEAL 945

  Fly  2573 -------ICGHIPQSLISETDVTCMAAKLSVSFFIETFIHAKEKPTMVPWVELLTKQFNASQEAC 2630
                   .|.   :||:|..:      .|.|.   ||.|....:..::...:.....|.:|||
Frog   946 TYLVYAYQCN---RSLVSSGE------SLGVE---ETLIQLYRRKCLLKLNDKAATLFESSQE-- 996

  Fly  2631 EWFLSHMSQEPYWPVQVLIQCPNQMVRQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQ 2694
                ..:|:.......::|.|.:.:.........:..|:::|..... ||..:.|::.:..:||
Frog   997 ----EQVSEGISIMNDLIIPCMHLIFNNKISEEDLSAIEEMRNRWCS-YLGQDIDDNLQMKLGQ 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	113/589 (19%)
		UCH	2014..2377	CDD:278850	110/580 (19%)
		DUF3517	2723..>2877	CDD:288853
usp28	XP_002937867.3	UBA_UBP28	1..42	CDD:270540
		UBP14	<138..611	CDD:227532	99/488 (20%)
		Peptidase_C19I	139..625	CDD:239130	101/501 (20%)
		USP28_C	825..1104	CDD:380452	47/256 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910