DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and usp34

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_002939554.2	Gene:	usp34 / 100490033	XenbaseID:	XB-GENE-920965	Length:	3550	Species:	Xenopus tropicalis

Alignment Length:	4123	Identity:	1546/4123 - (37%)
Similarity:	2181/4123 - (52%)	Gaps:	868/4123 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCEVCADFQNLLELYEVRVASSDLKFQLLLKSE-IETTFNYIQSWPQRQCMCLYRDTKNYDRFNL 64
            |||:|||...:|.    .::.|:....|.|:.| ....|.||.||.||||:|.:::.|:.:.||.
Frog     1 MCEICADLVEVLN----EISDSEGNDGLQLRKEHALKIFAYINSWTQRQCLCCFKEYKHLEIFNQ 61

  Fly    65 VVQSLICLTVQHLKHIDHLIDNYKRLTASAAQVVAQAQQQREQ--QRDEASAQAEAKESSAPAEE 127
            ||.:||.|                        |:.|.|..|:|  :....|..:..::...|:||
Frog    62 VVCALINL------------------------VIGQVQALRDQLLKICTTSPDSNWQDDHNPSEE 102

  Fly   128 --PKKEEPSGSAGEEAQGSGDGPAKKPPVGPCTPPP-----PQTANPQHKSHLQYTE--EPWILP 183
              ..::||....|||:...           ||.|..     .:|.|...:..::.|:  ..|...
Frog   103 LLNVEKEPQDEEGEESHKQ-----------PCNPQEKTLDNTRTCNLTEEESIKSTDLFNLWSTD 156

  Fly   184 EVEKLLVLVSKVFLLNFPLYIAHKHGMHSRLDDLQAEEAHHLALICDLHDNDLPIYLLRNVSLFC 248
            |.||||:.|:|:|.:.||||.|:||..|..::|:.|:|::.|...||::|.::|::|||.|.|||
Frog   157 EKEKLLLCVAKIFQIQFPLYTAYKHNTHPTIEDISAQESNILGAFCDMNDVEVPLHLLRYVCLFC 221

  Fly   249 NSGGFGAMSLCFEH--PD-LPVSTAHSMTAAVSNVKLWLNYHCNTQLFVPLRSRILQYMCKLSDQ 310
            ...|...|..|||:  |: ||...||:....|||:::||:.....|..:|.|:.:::|:||||||
Frog   222 GKNGLSLMKDCFEYGTPETLPFQIAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIRYLCKLSDQ 286

  Fly   311 SLRSAATRAMADFVWSSMRDPLDVAVNFDTEGLALAFKYFTSTTLTMRLAGMAQINAHINLFNEI 375
            .||.:|.|.|||.:||::::|||.|:.||.|.|.||||||.|.||||||||::||...::.||::
Frog   287 ELRQSAARNMADLMWSTVKEPLDTALCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDV 351

  Fly   376 CTTET-VNEVEL-FGQRIANWLTENHIVQHLFGPNLHVEIVKQAHVLLNFLAVENQISEEDIKLI 438
            |..|: |::.|. ..:.:|:||..|::|:|:||||||:||:||..|:|||||.|.::|.:.|..|
Frog   352 CNNESLVSDTETSIAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCI 416

  Fly   439 WQATQLKHCSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALTKQLWTRD-T 502
            |.|.||||||:.|.|:.|||:|||.|.|..||.:|:..:.|..||||::|:||.|.|.||... .
Frog   417 WAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSGLHPSAHTEQTLYLASMLIKALWNNALA 481

  Fly   503 SRSQM------------NLMQDHLLGSNVTA-SSSDSG--------------------------- 527
            :::|:            ||...:..||..|: .|||:.
Frog   482 AKAQLSKQSSFASLLNTNLPMGNKKGSPATSPQSSDNSDTHHSGGSDIEMDEQILNRSKHVQQRL 546

  Fly   528 -----SIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRRHICDPTTEKGKQI 587
                 |::||:.|..:.|.|.||......|...|:.:.::.          .|........|.::
Frog   547 SDTEESMQGSSDETANSGEDASSGPGSSSGHSDGSSNEVNS----------SHASQSAGSPGSEV 601

  Fly   588 SPED------MAKVDLVNKRIVNIIDNTSSE---EELQSRAAL---ELQLHRSRKKTSNKRRRQK 640
            ..||      |.:.|..::..:|...|..||   .:|:|:|.:   |.|....|..|||     .
Frog   602 HSEDIVDMEAMKEDDEEDEHSINTAKNRVSELQKRKLESQAGICLGESQGPVERSTTSN-----G 661

  Fly   641 TNKQIILPHELVEIWDGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQLVPDAVLKHLQG 705
            :.|.::...|.|:..|....:..|.....|::.|..||:          :||         |:||
Frog   662 SGKDLVFNSESVQPGDSRIRILDSCSHPEESEHDMAGEM----------STS---------HIQG 707

  Fly   706 --------EGPFIRAIETN----------------------------------------INELLS 722
                    .|.|:.....|                                        ::::||
Frog   708 SIDTCIARSGDFLGEAIGNELFNCRRFIGPQHHHHHHHHHHHHHHHHHHHHHHHHEGHMVDDMLS 772

  Fly   723 GAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCSDVPPAFAAAAAAMMVAQSA 787
             |::....||.:|.|||||:||||.|: |.|||||.|:.|.
Frog   773 -ADDVSCSSSQVSAKSEKNMADFDGEE-SGCEEELVQINSH------------------------ 811

  Fly   788 MALQKSGESNVAAAAAAVAAAAAATGTAQQTLVAMNRQASVAAAAAVVAAAKAKSDSDVDLMDVV 852
                                 |..|...||.|..:   ||:
Frog   812 ---------------------AELTSHLQQHLPNL---ASI------------------------ 828

  Fly   853 SGGKQHHSPKASQGSST---SGSTPVQPSFKLNDVCQPGNTLLWDLLQDDKIGQLGESLALEAEK 914
                 :|. ..|||.|.   ..::.......|::||:.||||||||:|||....|.|.|..||||
Frog   829 -----YHE-HLSQGPSVHKHQYNSNAMVDINLDNVCKKGNTLLWDLVQDDDAIHLSEGLINEAEK 887

  Fly   915 ALATLLCFSMDRQLRTKFIEGCLYNVANNRSVIVSLRLLPKLFASFQQFRPS-DTHSMTMWAERN 978
            .|.:|:|:..|||:|.:||||||.|:||||||:||||||||||.:||||..| |||.:|||||:.
Frog   888 LLCSLVCWFTDRQIRMRFIEGCLENLANNRSVVVSLRLLPKLFGTFQQFGSSYDTHWITMWAEKE 952

  Fly   979 HRMMQCFFNNIRHYARRHAEVLITQNGEQQQQQLGGQLYSHKTQVSVRLQFLSSIFSTVGSPKSF 1043
            ..||:.||:|:.||      :...::|:.:.     .||||..:|.||||||:.:|||:|||..|
Frog   953 LNMMKLFFDNLVHY------IQSIRDGQHKH-----ALYSHSAEVQVRLQFLTCVFSTLGSPDHF 1006

  Fly  1044 RLTLEQLDALWEWLAHDPECADCYFSWLQAQAKGGDQHALGIEALQHLYLKKLPELRPEEFSMVA 1108
            ||:|||:|.||..|..|.||.|....|...|.:..||||:|:|..:||:|:|:|:|:||..||..
Frog  1007 RLSLEQVDILWHCLVEDTECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTG 1071

  Fly  1109 LGLFQQLCSFARIAMAEYDNHSDQISASASAVGMYHLWKIALRAQSNDVSLAAIQYINMYYMGQQ 1173
            |.|||.||:.||:|.:.||..|     ::...||...|.|||||.:.|||.|||||||.||:..:
Frog  1072 LNLFQHLCNLARLATSAYDGGS-----NSELCGMDQFWGIALRAHTGDVSRAAIQYINSYYINGK 1131

  Fly  1174 LRLEK--EFVSQCMENLVQAATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEG 1236
            ..|||  ||:|:|||:|:.|::.||. |.:::|..::||||:|.|||:.||||:|:|||:|.|||
Frog  1132 TGLEKEHEFISKCMESLMIASSNLEQ-DSQSSLTIIERGLLMLKTHLEAFRRRFAYHLRQWQIEG 1195

  Fly  1237 KGIGSHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESL---------- 1291
            .||.||....|:....|||||.|.|||.:|..::|:..|.:|||:|||:.|:|:|
Frog  1196 TGISSHLKALNDKQSLPLRIVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKDQMNQQAQ 1260

  Fly  1292 -----QTGLAAPVLGLLLSDGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYVSLGGRGARRKE 1351
                 |:.......|.|:  ||:|:|:.|.|||:||||::|.:.||||.|:|:||||.....||.
Frog  1261 LQEFGQSSRKGDFPGGLM--GPVRMISSGHELTTDYDEKTLHELGFKDMQMVFVSLGAPRRERKG 1323

  Fly  1352 SNLEHP-SMLPPPPKECLPTVLLLQPKYFEKLFCLMQTLGDMQPQASTV---NPQH------HTK 1406
            ..::.| |.||||.||.:|.:||||..:...||.|::.|...:|.:..:   :.:|      |..
Frog  1324 EGVQLPASCLPPPQKENIPMLLLLQEPHLSTLFGLLEMLASFKPPSGEMVMEDVEHARCEELHLH 1388

  Fly  1407 AQLLSRRVWDILAMLPTNPHILDAFKSLVTDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPN 1471
            |:.||||||::|.:|||.|::|.||:: |:|    ||...|              ..::|||...
Frog  1389 AENLSRRVWELLMLLPTCPNMLQAFQN-VSD----EQGSDG--------------PCWKDLLRIK 1434

  Fly  1472 NLQKFMYSLHIVESLALTSSRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMS 1536
            :..|.:|:|.|:|:|       |:.|.           |:::.|.|
Frog  1435 SAHKLLYALEIIEAL-------GKPNR-----------RIRRESTG------------------- 1462

  Fly  1537 KEQLCELEAPLTPTPSTGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPP 1601
                             ...|:..::..||    |:|
Frog  1463 -----------------SYSDLYPDSDDSS----EDQ---------------------------- 1478

  Fly  1602 SPTPPPPALSVVERGDNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKEL-ALNEWRHDCLASLL 1665
                       :|...|.||..||..|||:.|.|||:.|.|:    |||. :...|:.||||.||
Frog  1479 -----------IENSKNTWSCKFVAAGGLQQLIEIFNSGILE----PKEQESWTVWQLDCLACLL 1528

  Fly  1666 RILWL---------LGFEELQS----ADAHVLMSRP---------HPFML---QLMEVPQCLTRL 1705
            :::..         |.:.::.:    |::|...:.|         ||..|   :|.||...|.:.
Frog  1529 KLICQFAVDPTDLDLAYHDVFAWSGVAESHRKRAWPGKSRKSAGEHPKGLHIPRLTEVFLVLVQG 1593

  Fly  1706 SSILNDEVHQQHQASSANPLVFPYQFQHLRTGFWGRAQLIQFAMNILVSFVHASAEARRLLWAPT 1770
            :.::...:...:...:..|.|...|..|.     .|.::..::|.:|||:.|..:..:..|   .
Frog  1594 TCLIQRLMSVAYTYDNIAPRVLKAQSDHR-----SRHEVTHYSMWLLVSWAHCCSVVKSSL---A 1650

  Fly  1771 GTDHCR-WLQKFILEDPEPAVRREICAGLYRICLGNA-------HSYRLLLAPLLHKLI----AL 1823
            .:|:.: ||:|..|..||.|||.|.|.|||::.|...       .|:.||.|..|.|.:    ||
Frog  1651 DSDNLQDWLKKLTLLIPETAVRHEACNGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDAQAL 1715

  Fly  1824 LPLAEQMSSGNQHTQFLLSEEGKDPYGPACRDYFWLLARLVDTLSPEMVAEEH-IDIEMLCESIS 1887
            .|:..:    :...:.:|.        |.|::|||||.:|:|.:..:..::.. :|::.|...::
Frog  1716 KPVRME----DYEEEMILR--------PGCKEYFWLLCKLIDNIHVKDASQTTLLDLDALARHLA 1768

  Fly  1888 QSILTREYYELRHG-YQDDGLVGLLNLMSNLIKYDTTFKYTPKALSFIEQLIGFLFDMPSPADRQ 1951
            ..|.:||.::.:.| .:|||:.|||.|.:::||:...||::.:...|:..:...||.:||..|:.
Frog  1769 DCIRSREIFDYQDGNVEDDGMTGLLRLATSVIKHKPPFKFSREGQEFLRDVFNLLFLLPSLKDKL 1833

  Fly  1952 KPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVG 2016
            :|||||.||||:|||||||:.:|...||..||..::|||......||.|||||.|:.||||.:||
Frog  1834 QPKCKSHSSRAAAYDLLVEMVKGSVENYRLLHNWVMAQHMQSSHAPYKWDYWPHDDVRAECRFVG 1898

  Fly  2017 LTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSF 2081
            |||||||||:||.:|.|||:|:||.|:.....:...||..||||||:||.||:|||.|:||||.|
Frog  1899 LTNLGATCYLASTIQQLYMIPEARQAIFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPF 1963

  Fly  2082 CRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTA 2146
            |:.|.||.|||||||||||.|||.||::|:|:|:|:||:.||.||.|.::||||||||.|||:||
Frog  1964 CKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSPELKNTVKSLFGGVITNNVVSLDCEHVSQTA 2028

  Fly  2147 EDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMR 2211
            |:|||||||||||:|:.|||||||:|||||||||||||.|||||||||||||||||:||.|||||
Frog  2029 EEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMR 2093

  Fly  2212 YTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAE 2276
            ||||||||:||||||||||||||:|..|.|..||.   |.:|....||           |.|:.:
Frog  2094 YTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMG---KNDRIEGFKE-----------DCEEPK 2144

  Fly  2277 ATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIA 2341
            .|      |.|||:|:||||||||||||||||||::......:.:.:|:|||||||||||.:|:|
Frog  2145 QT------ESYEYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLA 2203

  Fly  2342 AECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKS 2406
            :||||||||:|||||||:|::|||||||:|||||||:|..||
Frog  2204 SECFGGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRVEPE----------------------- 2245

  Fly  2407 EAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIE 2471
                    |.:..|.|.||
Frog  2246 --------EETGREFKFDV---------------------------------------------- 2256

  Fly  2472 KQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLF 2536

Frog  2257 ----------------------------------------------------------------- 2256

  Fly  2537 RPLLNKELEDWIWQDNRQFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVTCMAAKLSVSFFIE 2601
                :.||.:|||.||.|||||:||||||||.||||:|..||.:|.....|:.|.||||.||.:|
Frog  2257 ----SSELLEWIWHDNMQFLQDKNIFEHTYFGFMWQLCSSIPSTLPDPKAVSLMTAKLSTSFVLE 2317

  Fly  2602 TFIHAKEKPTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPVQVLIQCPNQMVRQMFQRLVIH 2666
            ||||:||||||:.|:||||||||.||.||||||..|:.:.:||:|:||:||||:||||||||.||
Frog  2318 TFIHSKEKPTMLQWIELLTKQFNNSQAACEWFLDRMADDDWWPMQILIKCPNQIVRQMFQRLCIH 2382

  Fly  2667 VIQQLRASHAHLYLE--VETDEDDK----ELIGQASCVTRFIGSLISLLEHGARANLRHLSEYFG 2725
            |||:||..||||||:  :|...||.    |.||..||||||:.:|:|::|||.:.:.:||:|||.
Frog  2383 VIQRLRPVHAHLYLQPGMEDGSDDMDGPVEDIGSRSCVTRFVKTLLSIMEHGVKPHSKHLTEYFA 2447

  Fly  2726 LLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHK--QTDSIDISSDNEDNSSEE-----ALSVEKM 2783
            .|.||.:||:||:.:||.:..:.::|.||:|.|  :...:::.|:.|:...||     :|:.||.
Frog  2448 FLYEFVKMGEEESQFLLSLQAISTMVHFYMGTKGPENPQVEVLSEEEEGEEEEEEDILSLAEEKY 2512

  Fly  2784 RPASLDKMIALCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGINPHQTKHLIHAL 2848
            |||:|:|||||.|.|||:|| ::..|.||..|.:|:.||||||||:|.|:||||..||.:||.:|
Frog  2513 RPAALEKMIALIAFLVEQSR-SERHLTLSQNDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSL 2576

  Fly  2849 CRWDERLATQIIGMLFASVTKHT-ELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAAEYC 2912
            ||::.|||..|..|||.|:.|.| |...|||||||::.|..|||.|:|.|...||.|:|:..||.
Frog  2577 CRYNNRLAEHIASMLFTSIAKLTPEAANPFFKLLTMIMEFAGGPPGMPPFASYILQRIWEVIEYN 2641

  Fly  2913 PQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPFRANFRA 2977
            |...||||::|..:||:||.|:||:.|.|:|:|||||:..|||.:||:|||:|:||..||..||:
Frog  2642 PSQCLDWLAVQTPRNKLAHNWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSNSFRQMFRS 2706

  Fly  2978 ----HSQHKLLALNPHSYRDINSDAQAVLHQVITLLLRLLRPARVYADIGAHGTTKLTAYFNLLS 3038
                |...:.|.|:|        |...|||||...||.||..|::|.|..|||||||..||:.::
Frog  2707 TRSLHIPTRDLPLSP--------DTTVVLHQVYNALLGLLSRAKLYVDAAAHGTTKLVPYFSFMT 2763

  Fly  3039 YCMVSKTEKLMASSYMRSLWELFHPRLSEPSVPAHHNKHALLTFWHHSLVDCPENAAQVANCPEI 3103
            ||::|||||||.|:|...||.||.|:||||::..:|||.|||:||::..||||||...:...|.:
Frog  2764 YCLISKTEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCVDCPENVRLIVQNPVV 2828

  Fly  3104 TRNIAFNYILADHDDAEIVTYNRSMLPAYYGLLRLCCEQSRALTRQLSQHQNLQWAFKNITPHPT 3168
            |:|||||||||||||.::|.:||.|||||||:||:|||||.|.||||:.|||:||||||:|||.:
Frog  2829 TKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRMCCEQSPAFTRQLASHQNIQWAFKNLTPHAS 2893

  Fly  3169 QYAAAVDELFKLMALFATRHPDASEQEKLDVTQFRRAVIVSYTSSLDARVSWSTLISALKILVDN 3233
            ||.|||:|||.||.||..:.||..|:|..|:.||::..|..|...||.|..|:|||||.:||:::
Frog  2894 QYPAAVEELFNLMQLFVAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLES 2958

  Fly  3234 EEDRTMVIFNGGIEMCFEALHTLHSMHHEATACHVAGDLFDLLGEMLLLLATLRTRTDSPAQKKQ 3298
            :|||.:|:||.|:.:..|:.:|||.|:||||||||.|||.:||...|.:|.:.|
Frog  2959 DEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTR----------- 3012

  Fly  3299 QQQQQQLEQQLQLQQQQMLQKQQQQSQSQTQTPQSPQQKEKQLQQQMQQHLQLQQLQQMQFQQQH 3363
                                                            .:||.:.::|...|.|.
Frog  3013 ------------------------------------------------PYLQRKDVKQALIQWQE 3029

  Fly  3364 FLRQQHQHSALAKALPDAVKRLATLLNTFNSPEISRMALEVLKELVRNPSLETISILAPILINCH 3428
            .:...|              :|.||||:::.||:....::||||||.....:.:..|.|.|.:.|
Frog  3030 RIEFAH--------------KLLTLLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNH 3080

  Fly  3429 LSV--ANAPNAIGPLGPYFP-RRGAKHTPWPLGAKNSPRPPRPMVQMCI--ALAELTPRGLDADY 3488
            .:.  :|.|.:   |||||| |...|    .:|||::.|||||.:.||:  .:.| :.:|.|..|
Frog  3081 CTYHHSNIPMS---LGPYFPCRENMK----LIGAKSNIRPPRPELNMCLLPTMVE-SNKGKDDVY 3137

  Fly  3489 DVQVESFYRPYHDFIDVMMRMCVNTGTLNDTLVKLQCLVAIESTPLHFTYFPKFWVGI--HNNAL 3551
            |..:..:...||.||.::.|:.:|.....:||:||..|:|.|...||...|||.|..:  ..:|:
Frog  3138 DRMLLDYLSSYHQFIHLLCRVAINCEKFTETLIKLSVLIAYEGLSLHLALFPKLWTELCQTQSAM 3202

  Fly  3552 THKYVELLVKNQLLVEYLHNVLRDERSMLKDACVREFLELYYHKVAAQL----PVARMIYTI--- 3609
            .....:||.::.:..||:..:|.|||..|.::.|..||..:..||.:|:    ..|.::.||
Frog  3203 AKSCTKLLCEDPVFAEYIKCILMDERLFLNNSIVYTFLTHFLGKVQSQVFSETNCANLMNTIITN 3267

  Fly  3610 ----------NYGMHSKDDIDE----LCGDLFAIRIIAQATGVPASVRKELRGSLRALQNKSERF 3660
                      ::|  ::.||.:    |.|||.|:.::. :...|..:...|..:|:.|.:|....
Frog  3268 LINQYQNVESDFG--NRVDISKASSTLNGDLRALALLL-SVHTPKQLNTALIPTLQELLSKCRAC 3329

  Fly  3661 RKESERDPFPNKKQKRDSQ--KIKEKEHPQPESEKETSTE-------------NDKPSDVSMESS 3710
            :::.      |..|:::::  |.|:.|...|...:..|::             ||:  :||..:|
Frog  3330 QQQR------NSLQEQEAKEGKTKDDEGATPVKRRRVSSDEEHMVDSCISDLKNDR--EVSTPTS 3386

  Fly  3711 GNAEQATDST--------KPPTPAGSDDEQMDKTSVPSSDDE--------TELEDELQPTPK--R 3757
            .:..:..||:        .||:|..|..::. :..|.||..|        .::||:...:.|  .
Frog  3387 TSDNETRDSSIIDPGTEQDPPSPENSSSKEF-RIEVSSSFSEDLMLSSRPQQVEDQTGSSSKFED 3450

  Fly  3758 NKKASNKKTAQDRVNEEREKRLITLITMESYIQSIFAILKRDASVPSSGATKEPSEEPCGEASTS 3822
            :|:..:.::.:|....:.:..|.:        .||.|:|...|.:.|..|....|.:|      .
Frog  3451 SKEMKDLQSPKDATVTDEDNELPS--------TSISAVLADLADLRSCDAQTLSSNDP------D 3501

  Fly  3823 AAAAVKLSRPKGACTPPEPITDVNDTRC 3850
            .:.::.....:|..:..:. .|:.||.|
Frog  3502 LSLSLNCDHSRGLFSHVQQ-NDILDTLC 3528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	245/368 (67%)
		UCH	2014..2377	CDD:278850	242/362 (67%)
		DUF3517	2723..>2877	CDD:288853	75/161 (47%)
usp34	XP_002939554.2	peptidase_C19C	1895..2244	CDD:239124	245/368 (67%)
usp34	XP_002939554.2	FCP1_C	<3324..3453	CDD:370422	26/137 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1101	1.000	Domainoid score	I22
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40978
Inparanoid	1	1.050	2533	1.000	Inparanoid score	I31
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12667at33208
OrthoFinder	1	1.000	-	-		FOG0008147
OrthoInspector	1	1.000	-	-		oto103743
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160