DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and usp18

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_005164589.1	Gene:	usp18 / 100334535	ZFINID:	ZDB-GENE-100210-2	Length:	337	Species:	Danio rerio

Alignment Length:	410	Identity:	85/410 - (20%)
Similarity:	146/410 - (35%)	Gaps:	111/410 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2001 DYWPR----------DEGRAECGYV--GLTNLGATCYMASCVQHLYMMPQARAAVLRV----PPN 2049
            |||.:          ....:..||.  ||.|.|.:|    ||..|.....|...:|.:    .|:
Zfish     3 DYWSKMAYHRRYIRSSSWSSNRGYEVRGLFNDGLSC----CVNALLQSFSATTELLDILNKWNPS 63

  Fly  2050 AARKHGPTLLELQRMFAYLLESERKSYNP-----------RSFCRVYQMDHQPLNTGEQKDMAEF 2103
            ...:.....|:|:..   ||.....|::.           .:.||..|.|...:          |
Zfish    64 DGIEQSNIPLQLRNT---LLSVRDPSHSAPHKGFLDCLYRHAICRYTQQDADEI----------F 115

  Fly  2104 FIDLVSKLEDMTPD--LKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQES- 2165
            .:.|...|:.| ||  |...::.|:...:...|..:||..:.|....::::...:.:..|..||
Zfish   116 HMILNLSLKQM-PDHELAQEIRSLYTIEVETQVTCMDCTFIHRLPNSYFSLPLVIHEGENTLESC 179

  Fly  2166 LDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSF 2230
            :.....|..||....:.|.:|.||...........||||||.:..|:. |...::| |:::..:|
Zfish   180 IKSFFKKQKLEVSEKFFCDRCEKKQPCAYEQKLVSLPQILCVHLKRFR-NEHGLIK-KLDSKVTF 242

  Fly  2231 PLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVT 2295
            |..|.:..:                       |.|..:...::..:|          :|.|..|.
Zfish   243 PETLKISVF-----------------------AAGQSENAASDSPQA----------DYSLFAVI 274

  Fly  2296 VHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEK 2360
            ||.|:|..|||.:||::.      ..:.|:..||:.|                      :..|.|
Zfish   275 VHIGSAMFGHYTAFIRQT------QDQMWYYANDSRV----------------------NQATWK 311

  Fly  2361 YLDFSFEKTNSAYMLFYERR 2380
            .:..:::...:||:|.|.::
Zfish   312 DVQDTYKGRETAYLLLYRKK 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	82/388 (21%)
		UCH	2014..2377	CDD:278850	80/382 (21%)
		DUF3517	2723..>2877	CDD:288853
usp18	XP_005164589.1	UCH	28..328	CDD:278850	79/380 (21%)
usp18	XP_005164589.1	Peptidase_C19	97..329	CDD:239072	63/305 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810