DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puf and usp48

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_005172973.1	Gene:	usp48 / 100332674	ZFINID:	ZDB-GENE-050522-197	Length:	1047	Species:	Danio rerio

Alignment Length:	740	Identity:	176/740 - (23%)
Similarity:	286/740 - (38%)	Gaps:	204/740 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2004 PRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGP-------TLLE- 2060
            |..|.|.:..:|||||||||||:.:.:|..:...:.|.|:.|...:.|..|..       |:.|
Zfish    78 PNSERRDKNTFVGLTNLGATCYVNTFLQVWFHNLELRRALYRFQNSRAEGHNTDSDYEPRTICEH 142

  Fly  2061 LQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLED-----MTPDLKH 2120
            ||.:||.|..|.|:..:|....:...:|     ||:|:|..||....:|.|||     ..|:|::
Zfish   143 LQYLFALLQNSNRRYIDPSGLVKALGLD-----TGQQQDAQEFSKLFLSLLEDTLSKQKDPNLQN 202

  Fly  2121 LVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQ 2185
            ::::.|||..|...|...||..|.....||.:...:...:||.|.:.|...::.|:|||.|.|..
Zfish   203 VIQQQFCGQFSYVTVCNKCGRESPLPSRFYELELNIQGHKNLTECVTEFLKEEKLDGDNRYYCES 267

  Fly  2186 CGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYK 2250
            |..|..|.:|...:.||:.|.|..||:.|:..:..|:|:||..|||..|:|          :.:.
Zfish   268 CQSKQNATRRIKLQSLPRTLNFQLMRFVFDRQSGHKKKLNTFISFPEVLDM----------EPFL 322

  Fly  2251 EERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTG-TADGGHYYSFIKERT 2314
            |.||                             |:| .|||..|.:|.| :|..|||.:.:::.
Zfish   323 EGRE-----------------------------EKC-TYELSAVLIHRGVSAYSGHYIAHVRDA- 356

  Fly  2315 KTSYHTHERWFLFNDAEVKPFDPS--QIAAECFGGEMTSKTYDSVTEK-YLDFSFEKTNSAYMLF 2376
                ||:: |:.|||.|::..:..  |:..|    |..::|..|.|.| .....:..:.:||||.
Zfish   357 ----HTND-WYKFNDEEIEKMEGKKLQLGIE----EDIAETAKSQTRKPKCSKGYHCSRNAYMLV 412

  Fly  2377 YERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSSSEI----KADVD----VEVEVEE 2433
            |:::..|..|..      :|...|...:|...::..|.|...||:    |..||    ...||:|
Zfish   413 YKQQTEEINQTE------SPVDVPAFLQKLVEQDNRKFEEWCSEMSDMRKQSVDKGKAKHEEVKE 471

  Fly  2434 KDKEKPAQTDTESKETPAKEEI---ADDKSKQDE------------------PEEKKIEKQ---- 2473
            ..:..||: |.:|.|....|.:   .||.:...|                  .|.|:|..:
Zfish   472 LYELLPAE-DGQSYEFVPLEWLKKWLDDSTAIKEIDNSQFLCTHGKLHPDKIGEAKRISLKAADL 535

  Fly  2474 --SREG----------------------EEKSETDEKPTEMTTVSTEEEKQPTANC--------- 2505
              ||.|                      ..|::.:|...|:|.::....|...:..
Zfish   536 LFSRYGGGPRLDRSSLCRDCVTQRCRVIRLKNQLNEDYREVTNLAKSALKSEESGFWIGKASLRS 600

  Fly  2506 ----------DNHQQNNNSNSKASNDQQPSTSKA-----------AQKLQLF------------- 2536
                      ::.::..::|||.:.::....:||           .::::.|
Zfish   601 WRQLALDQLEEDEEETKHNNSKINGEKSSPGTKADGVKGDSEDGDGEEMKNFNEDILCYHGGLSI 665

  Fly  2537 ----RPLLNKELEDWIWQDNR-------QFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVTCM 2590
                |.|::.|    :|...|       :|.||.:         ..|.|..:.:.......:..|
Zfish   666 LENDRRLVSAE----VWNKLRMYFPKAPEFTQDHD---------PCQQCMRLEREGKENEALNRM 717

  Fly  2591 AAKLSVSFFIETFIHAKEKPTMVPW 2615
            .|....|..:..| ..|.:||:..|
Zfish   718 MANEQKSSLLNLF-QEKNRPTLQKW 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	114/385 (30%)
		UCH	2014..2377	CDD:278850	113/379 (30%)
		DUF3517	2723..>2877	CDD:288853
usp48	XP_005172973.1	UCH	89..413	CDD:278850	113/378 (30%)
		Peptidase_C19L	90..414	CDD:239133	112/378 (30%)
		DUSP	481..552	CDD:283896	12/70 (17%)
		UBQ	941..1047	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910