DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment puf and usp47

DIOPT Version :9

Sequence 1:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster
Sequence 2:	XP_031755561.1	Gene:	usp47 / 100036690	XenbaseID:	XB-GENE-5760041	Length:	1374	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	184/853 - (21%)
Similarity:	320/853 - (37%)	Gaps:	220/853 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1883 CESISQSIL--------TREYYE---LRHGYQDDGLVGLLNLM-----SNLI---KYDTTFKYTP 1928
            |::|::.|.        .::.||   .:.||    :.|..:||     ||::   ..|.|...|.
Frog    53 CKNINERITLNLPASTSVKQLYEDVSSKAGY----VSGTFSLMWGNGASNMVDMAALDPTPDRTL 113

  Fly  1929 KALSFIEQLIGFLFDMPSPADR-QKPKCKSASSRASAYD----------LLVELCRGCATNYA-- 1980
            :...|......||.......:: |....:|.::.:|..|          |..|....|.::|.
Frog   114 QEAGFEAGKKNFLHLTDKNGEQPQLTSDESGTADSSGLDDSTQEKFIGPLPREESVACTSDYVSQ 178

  Fly  1981 -YLHGRLLAQHKSGPKQPYPWDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVL 2044
             |.:..||:                    :::.|||||.|...|||:.|.:|.|:|.|:.|.|:.
Frog   179 NYSYSSLLS--------------------KSDTGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALY 223

  Fly  2045 RVPPNAARKHGPTLL--ELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDL 2107
            :.....:.:...:.:  :|||:|..|..|::::.......|.:..|..  ...:|.|:.|....:
Frog   224 KWEFEESEEDPVSSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSS--EAWQQHDVQELCRVM 286

  Fly  2108 VSKLEDMTPDLKH--LVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQV------ADMRNLQE 2164
            ...||......:.  |:.:|:.|.|.:.|..|:||:.|...:.|..:...:      ....:::|
Frog   287 FDALEQKWKQTEQADLINQLYQGKLKDYVKCLECGYESWRIDTFLDIPLVIRPFGSNTAFGSMEE 351

  Fly  2165 SLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFS 2229
            :|......:||:|.|.|.|.:|.:|..|.|...|...|.:|.....|:.|:..:|.:.|:|...:
Frog   352 ALQAFIQPETLDGPNQYFCERCKRKCDARKGLKFLHFPYLLTLQLKRFDFDYTSMHRIKLNDRMT 416

  Fly  2230 FPLRLNMCHYVEKTLMPQQYKEERERRQKEK---EGADGSGD-GNDNEKAEATLDDDIEE--CYE 2288
            ||..|:|..:::        .|:.:..|.:.   .||:..|. .:|....:.:.||.::|  |.|
Frog   417 FPDELDMSPFID--------VEDEKSPQTDSCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLE 473

  Fly  2289 ------------------YELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPF 2335
                              |||..|.||:|:|.|||||:.||.      ....:|:.|||..|
Frog   474 TNSNIEKLNKSVSEKNSLYELFSVMVHSGSAAGGHYYACIKS------FADGQWYSFNDQHV--- 529

  Fly  2336 DPSQIAAECFGGEMTSKTYDSVT--EKYLDFSFEKTNSAYMLFY-------ERRLPEHLQ-RRHS 2390
              |:|..|..     .|||...|  ..|...:|..:.:||||.|       ..:.||.:: ..|.
Frog   530 --SRITQEDI-----KKTYGGSTGNRGYYSSAFASSTNAYMLMYRLKNPARNAKFPEAIEFPEHI 587

  Fly  2391 ELLVTPTPSPTVEEKSEAE-------------EPTK--METSSSEIKADVDVE--VEVEEKDKEK 2438
            :|||........:||.:.|             .|.|  |..|..|:..|..::  ||:..|..:.
Frog   588 KLLVQKEQEQEEQEKRQREIERNTCKLKLFCMHPVKQIMMESKLEVHKDKTMKEAVEIAHKLMDL 652

  Fly  2439 PAQTDTESKETPAKEEIAD--DKSKQDEPEE------------------------KKIEKQSREG 2477
            ......:.......:|..|  ::|.:||.:.                        .::.:..:.|
Frog   653 EGVISLDCCRLVKYDEFHDYLERSYEDEEDRTMGYLLGGVKSSYMFDLLLETKRPDQVFQSYKPG 717

  Fly  2478 EE---------KSETDEKPTEMTTVSTE---EEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAA 2530
            |.         |:||...|..:....::   |.||..:.              |.|..|.|.:..
Frog   718 EVMVKVYVVDLKTETVAPPVSVRAYLSQTIIEFKQLISK--------------SVDLLPDTMRVV 768

  Fly  2531 -----QKLQLFRPLLNKELE-DWIWQDNRQFLQDRNIFEHTYF---NFMWQICG----------- 2575
                 ..|:|.. :.||.|: :..::.|:.|::..:..::...   :.:|::..
Frog   769 LERCYNDLRLLN-VANKTLKAEGFFRSNKVFVESSDSLDYQLVFTDSHLWKLLDRHANTIRLYVS 832

  Fly  2576 ---HIPQS 2580
               |.||:
Frog   833 LPEHTPQT 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/411 (26%)
		UCH	2014..2377	CDD:278850	106/398 (27%)
		DUF3517	2723..>2877	CDD:288853
usp47	XP_031755561.1	peptidase_C19C	192..571	CDD:239124	108/404 (27%)
usp47	XP_031755561.1	MSCRAMM_ClfB	<834..1029	CDD:411414	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910