DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment atl and RNF112

DIOPT Version :9

Sequence 1:NP_001287506.1 Gene:atl / 42934 FlyBaseID:FBgn0039213 Length:541 Species:Drosophila melanogaster
Sequence 2:XP_006721634.1 Gene:RNF112 / 7732 HGNCID:12968 Length:639 Species:Homo sapiens


Alignment Length:547 Identity:151/547 - (27%)
Similarity:216/547 - (39%) Gaps:125/547 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 INASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73
            ||||  ...:|...|::..|.....:|..||:::|.|....||||||:..|:.:...........
Human   142 INAS--GGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLNHLLQGLPGLESGEGGRP 204

  Fly    74 WLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRDCATV 138
             .|||:. |:|..|  |:.....||.|||..||.. ..|.|:|:.|:||..|...:.:......:
Human   205 -RGGEAS-LQGCRW--GANGLARGIWMWSHPFLLG-KEGKKVAVFLVDTGDAMSPELSRETRIKL 264

  Fly   139 FALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYEAEYG 203
            .||:|||||.||.:.||.:::.||.:|::|.....:.....|..|.|.|..||||.|.|.:|..|
Human   265 CALTTMLSSYQILSTSQELKDTDLDYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHPNKAGQG 329

  Fly   204 ALGGDKILKRRLEVSDK---QHPELQSLRRHISSCFTEVACFLMPHPG---LNVA-TNPKFDGRL 261
            .: |:......|..|.:   ::|::|.|.:.     ....|.|:|.||   :|.. .:|      
Human   330 HV-GNIFQSTPLAASQRLSGRYPKVQELLQG-----KRARCCLLPAPGRRRMNQGHASP------ 382

  Fly   262 QDITPEFKSSLRSLVPMLL--APDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLV 324
            .|...:|:..|.:.|..:|  ||          |..::|     .|.|.|          :...|
Human   383 GDTDDDFRHLLGAYVSDVLSAAP----------QHAKSR-----CQGYWN----------EGRAV 422

  Fly   325 ATAEANHLTAVAAAKE---LYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGE 386
            |..:...||....|:|   |.|.:.....|.|.|....|  |...||..:      ||||     
Human   423 ARGDRRLLTGQQLAQEIKNLSGWMGRTGPGFTSPDEMAA--QLHDLRKVE------AAKR----- 474

  Fly   387 EFTEKFRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANF 451
            ||.|..|:|      :|.|        |.||.|.|         |:...:..:     |.|..:.
Human   475 EFEEYVRQQ------DVAT--------KRIFSALR---------VLPDTMRNL-----LSTQKDA 511

  Fly   452 CNLVMGVALL------TL-ALWAYI-------------RYSGELSDFGGKLDDFATLLWEKFMRP 496
            .....|||||      || ||.|.:             |:.|.|:..||.:.  |.|:      .
Human   512 ILARHGVALLCKGRDQTLEALEAELQATAKAFMDSYTMRFCGHLAAVGGAVG--AGLM------G 568

  Fly   497 IYHGCMEKGIHHVATHATEMAVGGGAA 523
            :..|.:..|:...|..|....|..|||
Human   569 LAGGVVGAGMAAAALAAEAGMVAAGAA 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atlNP_001287506.1 GBP 14..289 CDD:280433 83/283 (29%)
MSC <316..>471 CDD:286487 44/177 (25%)
RNF112XP_006721634.1 RING 56..101 CDD:238093
GBP 163..402 CDD:206650 77/255 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142065
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2037
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10751
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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