DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and atl1

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_005157066.1	Gene:	atl1 / 571909	ZFINID:	ZDB-GENE-030131-8003	Length:	559	Species:	Danio rerio

Alignment Length:	487	Identity:	289/487 - (59%)
Similarity:	376/487 - (77%)	Gaps:	4/487 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQVINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHD 70
            |||:...::|||.|:|.|||::|:.:||:||.|..:|||||||||||||:||.||||||:    .
Zfish    36 VQVLVVKDDHTFELDEAALSKILLSEEVRDREVVAISVAGAFRKGKSFLMDFMLRYMYSQ----A 96

  Fly    71 ATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRDC 135
            :..|||...:||.||||||||||:||||.:||::||.|.|:|.|:|::|:||||.||||||:||.
Zfish    97 SEKWLGDAEEPLTGFSWRGGSERETTGIQIWSEVFLVDKPDGSKVAVLLMDTQGTFDSQSTLRDS 161

  Fly   136 ATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYEA 200
            |||||||||:||:|:||:|||:||||||||||||||||||:.:|..||||.|.|||||||||||.
Zfish   162 ATVFALSTMISSMQVYNISQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEF 226

  Fly   201 EYGALGGDKILKRRLEVSDKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRLQDIT 265
            .||..||.|.|::||::|:.||.|||::|:||.||||.::|||||||||.|||||.|||||::|.
Zfish   227 PYGQEGGMKFLEKRLKISENQHEELQNVRKHIHSCFTNISCFLMPHPGLKVATNPHFDGRLREID 291

  Fly   266 PEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEAN 330
            .||.::|:.|||.||.|.||..|||:|.::..|.|::||::|:.||:|.|||.|||||.||||||
Zfish   292 QEFINNLQVLVPCLLRPKNLDVKEINGSKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEAN 356

  Fly   331 HLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEKFRKQ 395
            :|.|||.||:||.:.||.|.||.||:|:.:.||..||.::::||..|.:.:|||||||:.::..|
Zfish   357 NLAAVAGAKDLYNRKMEVVSGGDRPFLAPSELQARHLEIREEALALFRSVKKMGGEEFSRRYLLQ 421

  Fly   396 LEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVMGVAL 460
            ||.:::|:|..|..||:|||||.||||||..|....:||:.:||.|.||:...|:.||:|:|.||
Zfish   422 LETEIDELFVQYIKHNDSKNIFHAARTPATLFVVIFVMYVAAGITGFVGVDVIASVCNMVLGFAL 486

  Fly   461 LTLALWAYIRYSGELSDFGGKLDDFATLLWEK 492
            :||..|||||||||..:.|..:|..|..||::
Zfish   487 ITLCTWAYIRYSGEYRELGAVIDQVAGALWDQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	180/274 (66%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	83/154 (54%)
atl1	XP_005157066.1	P-loop_NTPase	44..306	CDD:304359	175/265 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575008
Domainoid	1	1.000	378	1.000	Domainoid score	I814
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	606	1.000	Inparanoid score	I895
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		otm25266
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800