DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and gbp2

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_699217.2	Gene:	gbp2 / 570622	ZFINID:	ZDB-GENE-070912-618	Length:	627	Species:	Danio rerio

Alignment Length:	430	Identity:	97/430 - (22%)
Similarity:	174/430 - (40%)	Gaps:	79/430 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLNEDALSEVLMRDEVKDRF------VCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLG 76
            ::..|...::.::.|.||..      |.||||.|.:|.|||:|:                 :.|.
Zfish    13 LIENDEFGKLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLM-----------------NRLA 60

  Fly    77 GESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCATVFA 140
            |:.   .||:.....|..|.||.||  ...|.|..|.  .::||||:|..| .:...|....:|.
Zfish    61 GKQ---SGFALGSTIESKTKGIWMW--CVPHPYKKGH--TLVLLDTEGLGDVDKGDERHDTWIFC 118

  Fly   141 LSTMLSSVQIYN---LSQNIQEDDLQHLQLFTEYGRL-----ALADTGK-----KPFQRLQFLVR 192
            |:.:|||..:||   :..|:..:.|.::...||..|:     .:.|..:     :.|....:.||
Zfish   119 LAVLLSSALVYNSLGVIDNMALEKLHYVTELTENIRVKAEGNEVEDEDESAEFMRVFPSFVWAVR 183

  Fly   193 DWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVACFLMPHPGLNVATN 254
            |::...:.....:..|:.|:..|:......|::...   ||.:...|....||:.|.|     .:
Zfish   184 DFTLELKMGDKPITSDEYLESALKPKKGNSPQIAQYNLPRRCLREFFAPRKCFVFPRP-----AS 243

  Fly   255 PKFDGRLQDITPEFKSSLRSLVPMLLAPDN----LVY-----KEISGQR-VRARDLIQYFQSYMN 309
            .:...|::|:|.|      .|....|...|    .:|     |.:.|.| :....|....:.|:.
Zfish   244 TQDMKRMEDLTEE------ELDSEFLQQANTFCSYIYNSTEPKTVKGGRTITGTALGNLAEVYVE 302

  Fly   310 IYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKAL 374
            ..:..::|..::.:|:.|:..::.||..|.::|   |.|:....:..|....|.:.|...:.||:
Zfish   303 AIRSGKVPCLENAVVSLAKIQNVRAVEQALQIY---MTEMLSMAQFPLDPEELSSIHTLAEKKAI 364

  Fly   375 -----FQFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQA 409
                 ..|:...::..:|...|...:.:|..::   |:||
Zfish   365 EEFINMSFSDNDQIYQQELMGKIHNEYQDLCQQ---NHQA 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	71/302 (24%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	21/99 (21%)
gbp2	XP_699217.2	P-loop_NTPase	20..281	CDD:304359	70/295 (24%)
		GBP_C	284..579	CDD:202427	25/124 (20%)
		GBP_C	290..579	CDD:293879	23/118 (19%)
		coiled coil	548..559	CDD:293879
		coiled coil	568..579	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850