DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and gbp4

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001038355.1	Gene:	gbp4 / 559296	ZFINID:	ZDB-GENE-060531-46	Length:	618	Species:	Danio rerio

Alignment Length:	430	Identity:	98/430 - (22%)
Similarity:	171/430 - (39%)	Gaps:	86/430 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWS 102
            |.||:|.|.:|.|||||:                 :.|.|:.   .||:.....:..|.||.||
Zfish    33 VVVVAVVGPYRTGKSFLM-----------------NRLAGKR---TGFALSSNIKPKTEGIWMW- 76

  Fly   103 DIFLHDYPNGDKIAIILLDTQGAFDSQ--STVRDCATVFALSTMLSSVQIYN---LSQNIQEDDL 162
               ...:|......::||||:|..|.:  .:.|| ..:|:|:.:|||..:||   ...|:..:.|
Zfish    77 ---CVPHPTKAGTTLVLLDTEGLGDVEKGDSKRD-TYIFSLTVLLSSTLVYNSWGTIDNLAIEQL 137

  Fly   163 QHLQLFTEYGRLALADTG------KKPFQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEV---S 218
            |::....|:.::...:..      .|.|....:.:||::...:.:...|..|:.|:..|::   :
Zfish   138 QYVTELIEHIKVTPDEDADDCAEFAKFFPHFIWCLRDFTLELKLDGKDLTEDEYLEFALKLRPGT 202

  Fly   219 DKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRLQDITPEFKSSLRSLVPMLLAP- 282
            .|:.......|..|...|....||..|.|                .|||.:|.|.||.|...:|
Zfish   203 SKKVMMYNLPRECIRKFFPCRTCFTFPSP----------------TTPEKRSILESLSPAEFSPE 251

  Fly   283 -------------DNLVYKEI-SGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEANHLT 333
                         |....|:: .|..|..|.|....:.|::......:...::.::|.|:..:..
Zfish   252 FLEVTKRFCKFVFDRSEVKQLKGGHTVTGRVLGNLTKMYVDTISSGAVFCLENAVIAMAQIENEA 316

  Fly   334 AVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEKFRKQLED 398
            |.....|:|.:.||:: ..:.| |....:.:||.|:...|...|.|:   ..::...|..|.||.
Zfish   317 ATQEGLEVYQRGMEKL-KSSFP-LELEQVSSEHQRLSRMATQAFMAR---SFKDTDGKHLKALEG 376

  Fly   399 DLEEVFTNYQAHNESKN--------IFKAARTPA---VYF 427
            ::.::|..|::.|:...        ::...:.|.   |||
Zfish   377 EIGKLFDAYRSQNKQVGLETHCDLLLYMRCKDPLILHVYF 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	66/278 (24%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	26/123 (21%)
gbp4	NP_001038355.1	P-loop_NTPase	40..272	CDD:304359	63/272 (23%)
		GBP_C	280..>402	CDD:303769	25/126 (20%)
		CARD_ASC_NALP1	532..614	CDD:260039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750