DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and ATL1

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_056999.2	Gene:	ATL1 / 51062	HGNCID:	11231	Length:	558	Species:	Homo sapiens

Alignment Length:	511	Identity:	284/511 - (55%)
Similarity:	389/511 - (76%)	Gaps:	15/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQVINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHD 70
            |||:...::|:|.|:|.||:.:|:.:.|:|:.|..||||||||||||||:||.|||||::    :
Human    35 VQVLIVKDDHSFELDETALNRILLSEAVRDKEVVAVSVAGAFRKGKSFLMDFMLRYMYNQ----E 95

  Fly    71 ATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRDC 135
            :.||:|..::||.||||||||||:||||.:||:|||.:.|:|.|:|::|:||||.||||||:||.
Human    96 SVDWVGDYNEPLTGFSWRGGSERETTGIQIWSEIFLINKPDGKKVAVLLMDTQGTFDSQSTLRDS 160

  Fly   136 ATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYEA 200
            |||||||||:||:|:||||||:||||||||||||||||||:.:|..||||.|.|||||||||||.
Human   161 ATVFALSTMISSIQVYNLSQNVQEDDLQHLQLFTEYGRLAMEETFLKPFQSLIFLVRDWSFPYEF 225

  Fly   201 EYGALGGDKILKRRLEVSDKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRLQDIT 265
            .|||.||.|.|::||:||..||.|||::|:||.||||.::|||:|||||.|||||.|||:|::|.
Human   226 SYGADGGAKFLEKRLKVSGNQHEELQNVRKHIHSCFTNISCFLLPHPGLKVATNPNFDGKLKEID 290

  Fly   266 PEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEAN 330
            .||..:|:.|:|.||:|::|..|||:|.::..|.|::||::|:.||:|.|||.|||||.||||||
Human   291 DEFIKNLKILIPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEAN 355

  Fly   331 HLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEKFRKQ 395
            :|.|||.||:.|.:.|||:|||.:|:|:...|||:||::|::::..|...:|||||||:.::.:|
Human   356 NLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQ 420

  Fly   396 LEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVMGVAL 460
            ||.:::|::..|..||:|||||.||||||..|....|.|:::|:.|.:||...|:.||::||:.|
Human   421 LESEIDELYIQYIKHNDSKNIFHAARTPATLFVVIFITYVIAGVTGFIGLDIIASLCNMIMGLTL 485

  Fly   461 LTLALWAYIRYSGELSDFGGKLDDFATLLWEKFMRPIYHGCMEKGIHHV----ATH 512
            :||..|||||||||..:.|..:|..|..||::       |...:.::.:    |||
Human   486 ITLCTWAYIRYSGEYRELGAVIDQVAAALWDQ-------GSTNEALYKLYSAAATH 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	175/274 (64%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	79/154 (51%)
ATL1	NP_056999.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		GBP	43..314	CDD:308078	175/274 (64%)
		Sufficient for membrane association	448..558		35/94 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142059
Domainoid	1	1.000	387	1.000	Domainoid score	I803
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	627	1.000	Inparanoid score	I862
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		otm42142
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800