DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and Rnf112

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_619516.1	Gene:	Rnf112 / 24916	RGDID:	3986	Length:	631	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	134/532 - (25%)
Similarity:	210/532 - (39%)	Gaps:	96/532 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 INASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73
            ||||  ...:|...|::..|.....:|..||:::|.|....|||||||..||.:         ..
  Rat   142 INAS--GGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLRGL---------PG 195

  Fly    74 WLGGES------DPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTV 132
            ...|:|      ..|.|..|  |:...|.||.|||..||.. ..|.|:|:.|:||......:.:.
  Rat   196 LESGDSTRPRAEGSLPGIRW--GANGLTRGIWMWSHPFLLG-KEGKKVAVFLVDTGDVMSPELSR 257

  Fly   133 RDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFP 197
            .....:.||:.||||.||.|.||.:::.||.:|::|.....:.....|..|.|.|..||||.|..
  Rat   258 ETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHH 322

  Fly   198 YEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVACFLMPHPGLNVATNPKFD- 258
            .::..|.:|  .||::   :|.| :|::|.|   :|        ..|:|:|.|........:..
  Rat   323 NKSGQGHVG--DILQK---LSGK-YPKVQELLLGKR--------ARCYLLPAPERQWVNKGQASP 373

  Fly   259 -GRLQDITPEFKSSLRSLVPMLL--APDNL------VYKE-----------ISGQRVRARDLIQY 303
             |..:|   :|....|:.:..:|  ||.:.      .:.|           ::||::...  |:.
  Rat   374 GGNTED---DFSHHFRAYISDVLSTAPQHAKSRCQGYWSEGRAMARGDRRLLTGQQLAQE--IKN 433

  Fly   304 FQSYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLR 368
            ...:|. ..|.....|..|   .|:.:.|..|.|||:.:.:.:.:....|:...|...:..:.:|
  Rat   434 LSGWMG-KSGPSFSSPDEM---AAQLHDLRKVEAAKKEFEEYVRQQDIATKRIFSALRVLPDTMR 494

  Fly   369 -----VKDKALFQFAAKRKMGGEEFTEKFRKQLEDDLE-EVFTNYQAHNESKNIFKAARTPAVYF 427
                 .||..|.:.       |.....|.|:|..:.|| |:....:|..:|..:.......||..
  Rat   495 NLLSTQKDAILARH-------GVALLCKEREQTLEALEAELQAEAKAFMDSYTMRFCGHLAAVGG 552

  Fly   428 ACAVIMYILSGIFGLVGLYTFANFCNLVMGVALLTLALWAYIRYSGELSDFGGKLDDFATLLWEK 492
            |      :.:|:.||.|....|......:......:|..|.:..:|.....||.....|..:
  Rat   553 A------VGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATV--- 608

  Fly   493 FMRPIYHGCMEK 504
                   |||||
  Rat   609 -------GCMEK 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	82/293 (28%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	33/160 (21%)
Rnf112	NP_619516.1	RING	56..101	CDD:238093
		Interaction with ZBTB16. /evidence=ECO:0000250\|UniProtKB:Q96DY5	131..631		134/532 (25%)
		GBP	163..394	CDD:206650	76/259 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940