DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment atl and Rnf112

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001346059.1	Gene:	Rnf112 / 22671	MGIID:	106611	Length:	679	Species:	Mus musculus

Alignment Length:	555	Identity:	141/555 - (25%)
Similarity:	217/555 - (39%)	Gaps:	117/555 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 INASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73
            ||||  ...:|...|::..|.....:|..||:::|.|....|||||||..|..:.|..
Mouse   165 INAS--GGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLSGLPSLE------- 220

  Fly    74 WLGGES------DPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTV 132
              .|:|      ..|.|..|  |:...|.||.|||..||.. ..|.|:|:.|:||......:.:.
Mouse   221 --SGDSGRPRAEGSLPGIRW--GANGLTRGIWMWSHPFLLG-KEGKKVAVFLVDTGDVMSPELSK 280

  Fly   133 RDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFT--------EYGRL--------------- 174
            .....:.||:.||||.||.|.||.:::.||.:|::|.        .||.:
Mouse   281 ETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQVRQFLVSSILTH 345

  Fly   175 --ALADTGKKPFQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISS 234
              .|..:|...||.|..||||.|...::..|.:|  .||::   :|.| :|::|.|   :|
Mouse   346 QSRLPVSGPFLFQHLDLLVRDSSHHNKSGQGHVG--DILQK---LSGK-YPKVQELLLGKR---- 400

  Fly   235 CFTEVACFLMPHPGLNVA----TNPKFDGRLQDITPEFKSSLRSLVPMLL--APDNL------VY 287
                ..|:|:|.|.....    .:|:  |..:|   :|....|:.:..:|  ||.:.      .:
Mouse   401 ----ARCYLLPAPERQWVNKDQASPR--GNTED---DFSHHFRAYILDVLSTAPQHAKSRCQGYW 456

  Fly   288 KEISGQRVRARD--LI---QYFQSYMNI--YKGNELPEPKSMLVATAEANHLTAVAAAKELYGQL 345
            .|  |:.|...|  |:   |..|...|:  :.|...|...|.....|:.:.|..|.|||:.:.:.
Mouse   457 SE--GRAVARGDRRLLTGQQLAQEIKNLSGWMGKTGPSFNSPDEMAAQLHDLRKVEAAKKEFEEY 519

  Fly   346 MEEVCGGTRPYLSTAHLQTEHLR-----VKDKALFQFAAKRKMGGEEFTEKFRKQLEDDLE-EVF 404
            :.:....|:...|...:..:.:|     .||..|.:.       |.....|.|:|..:.|| |:.
Mouse   520 VRQQDIATKRIFSALRVLPDTMRNLLSTQKDAILARH-------GVALLCKEREQTLEALEAELQ 577

  Fly   405 TNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVMGVALLTLALWAYI 469
            ...:|..:|..:.......||..|      :.:|:.||.|....|......:......:|..|.:
Mouse   578 AEAKAFMDSYTMRFCGHLAAVGGA------VGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAV 636

  Fly   470 RYSGELSDFGGKLDDFATLLWEKFMRPIYHGCMEK 504
            ..:|.....||.....|..:          |||||
Mouse   637 GATGAAVVGGGVGAGLAATV----------GCMEK 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	86/320 (27%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	33/160 (21%)
Rnf112	NP_001346059.1	RING-HC_RNF112	78..125	CDD:319452
		RING-HC finger (C3HC4-type)	80..120	CDD:319452
		P-loop_NTPase	186..409	CDD:393306	74/248 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840