DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and Gbp2

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_034390.1	Gene:	Gbp2 / 14469	MGIID:	102772	Length:	589	Species:	Mus musculus

Alignment Length:	445	Identity:	99/445 - (22%)
Similarity:	165/445 - (37%)	Gaps:	103/445 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGE 78
            |...|:|::|| .:|   ....:.|.||::.|.:|.|||:|:                 :.|.|:
Mouse    18 EAQLVINQEAL-RIL---SAITQPVVVVAIVGLYRTGKSYLM-----------------NKLAGK 61

  Fly    79 SDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKI--AIILLDTQGAFDSQ--STVRDCATVF 139
            .   .|||.....:..|.||.||.      .|:..|.  .::||||:|..|.:  ....|| .:|
Mouse    62 R---TGFSLGSTVQSHTKGIWMWC------VPHPKKAGQTLVLLDTEGLEDVEKGDNQNDC-WIF 116

  Fly   140 ALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP-----------------FQRL 187
            ||:.:|||..|||....|.:..:..|...||     |.|..|..                 |...
Mouse   117 ALAVLLSSTFIYNSIGTINQQAMDQLHYVTE-----LTDLIKSKSSPDQSGVDDSANFVGFFPTF 176

  Fly   188 QFLVRDWSFPYEAEYGALGGDKILKRRLEV---SDKQHPELQSLRRHISSCFTEVACFLMPHPG- 248
            .:.:||:|...|.....:..|:.|:..|.:   :||:.......|..|...|.:..||:...|.
Mouse   177 VWTLRDFSLELEVNGKPVTSDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQ 241

  Fly   249 ------LNVATNPKFDGRLQDITPEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSY 307
                  |......:..|...:...||.|.:.|...:......::   ::|.|:::     ..|:|
Mouse   242 RKQLSKLETLREEELCGEFVEQVAEFTSYILSYSSVKTLCGGII---VNGPRLKS-----LVQTY 298

  Fly   308 MNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDK 372
            :.......||..:|.::..|:..:..||..|...|.:.|.:..  ..|..:...|...|..::.:
Mouse   299 VGAISNGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKI--QMPTETLQELLDLHRPIESE 361

  Fly   373 ALFQFAAKRKMGGEEFTEKFRKQL-----------------------EDDLEEVF 404
            |:..|.   |...::..:||:.:|                       .|.||::|
Mouse   362 AIEVFL---KNSFKDVDQKFQTELGNLLVAKRDAFIKKNMDVSSARCSDLLEDIF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	73/305 (24%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	22/112 (20%)
Gbp2	NP_034390.1	GTPase domain (Globular). /evidence=ECO:0000250	1..309		78/334 (23%)
		GBP	18..280	CDD:280433	73/297 (25%)
		GBP_C	282..578	CDD:202427	26/145 (18%)
		GBP_C	288..578	CDD:293879	26/136 (19%)
		coiled coil	547..558	CDD:293879
		coiled coil	567..578	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750