DRSC/TRiP Functional Genomics Resources

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Protein Alignment atl and GBP5

DIOPT Version :10

Sequence 1:NP_651274.1 Gene:atl / 42934 FlyBaseID:FBgn0039213 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_443174.1 Gene:GBP5 / 115362 HGNCID:19895 Length:586 Species:Homo sapiens


Alignment Length:467 Identity:106/467 - (22%)
Similarity:189/467 - (40%) Gaps:101/467 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGESDPLE 83
            :|::|| |:|   ....:.|.||::.|.:|.|||:|:                 :.|.|::   :
Human    23 VNQEAL-EIL---SAITQPVVVVAIVGLYRTGKSYLM-----------------NKLAGKN---K 63

  Fly    84 GFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCATVFALSTMLSS 147
            |||.....:..|.||.:|    ...:||.....::||||:|..| .::..::...:|||:.:|||
Human    64 GFSVASTVQSHTKGIWIW----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSS 124

  Fly   148 VQIYNLSQNIQEDDLQHLQLFTEYGRLALA------DTGKKP------FQRLQFLVRDWSFPYEA 200
            ..:||....|.:..:..|...||...|..|      |..:.|      |..|.:.:||:....|.
Human   125 TFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEI 189

  Fly   201 EYGALGGDKILKRRL---EVSDKQHPELQSLRRHISSCFTEVACFLMPHPG-----LNVATNPKF 257
            :...:..|:.|:..|   :.||::.......|..|...|.:..||:...|.     ..:.|.|. 
Human   190 DGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD- 253

  Fly   258 DGRLQDITPEFKSSLRSLVPMLLA-------PDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNE 315
                .::.|||...:......:.:       |..::   ::|.|::...|     :|:|.....:
Human   254 ----DELEPEFVQQVTEFCSYIFSHSMTKTLPGGIM---VNGSRLKNLVL-----TYVNAISSGD 306

  Fly   316 LPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHL---RVKDKALFQF 377
            ||..::.::|.|:..:..||..|...|.|.|     |.:..|....|| |.|   |..::...:.
Human   307 LPCIENAVLALAQRENSAAVQKAIAHYDQQM-----GQKVQLPMETLQ-ELLDLHRTSEREAIEV 365

  Fly   378 AAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHN-ESKNIFKAARTPAVYFACAVIMYILSGIFG 441
            ..|...  ::..:.|:|:||..|:....:....| |:.:.:.:|              :|..|||
Human   366 FMKNSF--KDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA--------------LLKDIFG 414

  Fly   442 LV------GLYT 447
            .:      |:|:
Human   415 PLEEAVKQGIYS 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
atlNP_651274.1 GBP 14..289 CDD:460516 69/297 (23%)
GBP5NP_443174.1 GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455 1..309 75/326 (23%)
NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501 1..306 74/323 (23%)
GBP 18..280 CDD:460516 68/289 (24%)
GBP_C 282..574 CDD:460721 37/175 (21%)
Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501 529..586
Blue background indicates that the domain is not in the aligned region.

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