Protein Alignment atl and GBP4

DIOPT Version :10

• Sequence 1: NP_651274.1
• Gene: atl / 42934
• FlyBaseID: FBgn0039213
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_443173.2
• Gene: GBP4 / 115361
• HGNCID: 20480
• Length: 640
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 107/464 - (23%)
• Similarity: 189/464 - (40%)
• Gaps: 80/464 - (17%)

  Fly    12 SEEHTFVLNEDALSEVLMRDEVKDRF---VCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73
            ::|....:|..||       |:.|:.   |.||::.|.:|.|||:|:                 :
Human    31 NQEEQLTVNSKAL-------EILDKISQPVVVVAIVGLYRTGKSYLM-----------------N 71

  Fly    74 WLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCAT 137
            .|.|:.:   ||......:.:|.||.||....| ..||.   .::||||:|..| .:|..::.:.
Human    72 RLAGKRN---GFPLGSTVQSETKGIWMWCVPHL-SKPNH---TLVLLDTEGLGDVEKSNPKNDSW 129

  Fly   138 VFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP------------FQRLQFL 190
            :|||:.:|||..:||....|....|:.|...||...|..|.:..:|            |....:.
Human   130 IFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWT 194

  Fly   191 VRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVACFLMPHPGLNVA 252
            |||::...:.:...:..|:.|:..|::...::|::|:.   |..|...|.:..||:...|
Human   195 VRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP----- 254

  Fly   253 TNPKFDGRLQDITPEFKSSLRSLVPMLLAPDNL---VYKEISGQRVR------ARDLIQYFQSYM 308
            ||.|......|..||......    .|:..||.   ::.....:.:|      .:.|.....:|:
Human   255 TNDKQYLNHMDEVPEENLERH----FLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYV 315

  Fly   309 NIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQ---TEHLRVK 370
            :......:|..::.:.|.|:..:..||..|.:.|.|.|.:     :..|.|..||   ..|...:
Human   316 DAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQ-----QLRLPTDTLQELLDVHAACE 375

  Fly   371 DKALFQFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYI 435
            .:|:..|   .:...::...:|:|:|.|.:|:...::...||..:. |..:......:..:...|
Human   376 REAIAVF---MEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASA-KYCQAELKRLSEHLTESI 436

  Fly   436 LSGIFGLVG 444
            |.|||.:.|
Human   437 LRGIFSVPG 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_651274.1	GBP	14..289	CDD:460516	74/296 (25%)
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..325		77/333 (23%)
		GBP	33..296	CDD:460516	74/302 (25%)
		GBP_C	298..594	CDD:460721	32/157 (20%)