DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atl and atl2

DIOPT Version :9

Sequence 1:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_004914749.1	Gene:	atl2 / 100379898	XenbaseID:	XB-GENE-947235	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	286/505 - (56%)
Similarity:	383/505 - (75%)	Gaps:	10/505 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQVINASE-EHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHH 69
            :|::.|.| :|.|.|:|.||..:||::.::|..|.|:||||||||||||||||.||:|||:
Frog    50 IQIVLAHEDDHNFELDETALESILMQEHIRDLNVVVLSVAGAFRKGKSFLLDFMLRFMYSQ---- 110

  Fly    70 DATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFDSQSTVRD 134
            .::.|:||:.:||.||:||||.||:||||.:||::|:.:.|:|.|:|::|:|||||||||||::|
Frog   111 SSSSWIGGDYEPLTGFTWRGGCERETTGIQIWSEVFVVEKPDGSKVAVMLMDTQGAFDSQSTIKD 175

  Fly   135 CATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKPFQRLQFLVRDWSFPYE 199
            ||||||||||.||||:|||||||||||||||||||||||||:.:..|||||.|.||:||||:|||
Frog   176 CATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYKKPFQTLMFLIRDWSYPYE 240

  Fly   200 AEYGALGGDKILKRRLEVSDKQHPELQSLRRHISSCFTEVACFLMPHPGLNVATNPKFDGRLQDI 264
            ..||..||:..|::||:|...||.|||::|:||.||||.:.|||:|||||.|||||.|||||.:|
Frog   241 HTYGLKGGNSFLEKRLQVKQNQHEELQNVRKHIHSCFTNIGCFLLPHPGLKVATNPYFDGRLAEI 305

  Fly   265 TPEFKSSLRSLVPMLLAPDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNELPEPKSMLVATAEA 329
            ..|||..||.|||:||||:|||.|||||.:|..|||::||::|:.||:|.|||.|||||.|||||
Frog   306 DDEFKKELRELVPLLLAPENLVEKEISGSKVTCRDLLEYFKAYIKIYQGEELPHPKSMLQATAEA 370

  Fly   330 NHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHLRVKDKALFQFAAKRKMGGEEFTEKFRK 394
            |::.|||.||:.|.:.||:||||.:||::.:.|:.:||.:|:..:.||.:.:|||||||..:::.
Frog   371 NNMAAVAGAKDTYSRSMEQVCGGDKPYIAPSDLERKHLDLKESCIKQFRSVKKMGGEEFCRRYQD 435

  Fly   395 QLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYILSGIFGLVGLYTFANFCNLVMGVA 459
            |||.::||.:.|:..||:.||||.||||||..||....|||:||:.|.:|:.:.|..|||:||:|
Frog   436 QLEAEIEESYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGMNSIATICNLIMGLA 500

  Fly   460 LLTLALWAYIRYSGELSDFGGKLDDFATLLWE-----KFMRPIYHGCMEK 504
            ||:...|||::||||..:.|..:|..|.::||     |....::..|..:
Frog   501 LLSFCTWAYVKYSGEFRELGTLIDQIAEIIWEQRSPKKVFSKLFEVCKRR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atl	NP_001287506.1	GBP	14..289	CDD:280433	177/274 (65%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	79/154 (51%)
atl2	XP_004914749.1	P-loop_NTPase	59..330	CDD:304359	177/274 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I820
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56949
Inparanoid	1	1.050	613	1.000	Inparanoid score	I891
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		otm49367
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160