DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx18 and UFE1

DIOPT Version :9

Sequence 1:	NP_524485.1	Gene:	Syx18 / 42933	FlyBaseID:	FBgn0039212	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_014718.1	Gene:	UFE1 / 854242	SGDID:	S000005601	Length:	346	Species:	Saccharomyces cerevisiae

Alignment Length:	420	Identity:	72/420 - (17%)
Similarity:	154/420 - (36%)	Gaps:	108/420 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DITQSFKASVMTV------------RLQRKAELAGKAKPATVPTKTGPIGPKDDFAKQAKEVCNK 54
            |:|..|:..|..:            .::||.|..|.:.......       :|.|.|:...:...
Yeast     4 DLTPIFRKYVAVIDDARNEQNGIDDHVERKQEDFGNSNETCEMF-------RDSFIKECARLLKF 61

  Fly    55 ITSLRNVLIENRTAYMRIGQHLKSAAHMTDAQRDLIDRESEKFVTFYTQHLAKMRSDWKSAKRKP 119
            :..|..|:.:....|:       ...:|:||::|..|.|....:..|.:.
Yeast    62 LVELNKVIKQIEKNYL-------DDFNMSDAEKDEFDMECRLQIQQYFKK--------------- 104

  Fly   120 QERQHIDAVLDLLVSYLHSVEQIYLDQKKYRVQHELETYRLLKLAADKK---KIPVRPAGSNSG- 180
                     .:.|.:|  .:|:..|..|::    :.:::|..|:.::|.   |..:.|....:|
Yeast   105 ---------FEFLENY--EMERHNLSLKRF----QSKSHRWSKILSNKNDNTKHVIHPQDIENGV 154

  Fly   181 ---KLGRRQVSN-----DDSEATKSSSQA-----NGNHDESADNDWNNDAWGDWDEDEEGDEVDD 232
               :||..:..|     ..|:.|....:.     ..|.:.:.....:|:|     :|...|.:|
Yeast   155 YEFRLGVLRCLNLWIKYVSSKFTTIQQERLILENKMNFNSTPMPTLSNNA-----DDFSADAID- 213

  Fly   233 HDGEKGKEANQANQHKPRTRKRSKANRSDLNNSSSKMALDEELQQQQEADDDDPLSAEDVQLFEA 297
                                       ..::.|:....:.:|::..:|.  ...|:.|.:|:.|.
Yeast   214 ---------------------------ISVSQSAPVETVQDEVKHYEET--ISKLTQEQLQVLET 249

  Fly   298 ENVHIYNFLQGVSEEVEQIEKNVVDIAQLQDIFTEKVAMQQHNIDRIVSAVVGTTENVKDANEQI 362
            |:..:.|......::||.|.|.::||..:|:..:..:.:|..||:.:::.......|:|..|:::
Yeast   250 EHSELLNQKNEQLKKVETINKTILDIVNIQNELSNHLTVQSQNINLMLNNQDDIELNIKKGNKEL 314

  Fly   363 RQATQRNAGLRVWSLFFLLVMSFSLLFLDW 392
            |:|.:........:.:..::|...:||||:
Yeast   315 RKAKRAAGRTAKMTTYGAIIMGVFILFLDY 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx18	NP_524485.1	Syntaxin-18_N	2..90	CDD:287468	18/99 (18%)
Syx18	NP_524485.1	SNARE_syntaxin18	306..364	CDD:277203	13/57 (23%)
UFE1	NP_014718.1	Syntaxin-18_N	4..90	CDD:402222	18/99 (18%)
		COG5325	<170..341	CDD:227635	33/205 (16%)
		SNARE_syntaxin18	258..316	CDD:277203	13/57 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3894
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004915
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103713
Panther	1	1.100	-	-	LDO	PTHR15959
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.740