DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syx18 and Stx18

DIOPT Version :9

Sequence 1:	NP_524485.1	Gene:	Syx18 / 42933	FlyBaseID:	FBgn0039212	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_001012151.1	Gene:	Stx18 / 360953	RGDID:	1310058	Length:	334	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	133/400 - (33%)
Similarity:	196/400 - (49%)	Gaps:	77/400 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDITQSFKASVMTVRLQRKA---ELAGKAKPATVPTKTGPIGPKDDFAKQAKEVCNKITSLRNVL 62
            :|||..|:|||.||:.:.||   .:.|.|..:..........||.||:.:|:||.:.|..||:.|
  Rat     3 VDITLLFRASVKTVKTRNKALGVAVGGGADGSRDELFRRSPRPKGDFSSRAREVISHIGKLRDFL 67

  Fly    63 IENRTAYMRIGQHLKSA-AHMTDAQRDLIDRESEKFVTFYTQHLAKMRSDWKSAKRKPQERQHID 126
            :|:|..|:....|..|. ..|||.:||.||::::.|:......:.::|::........|.::|..
  Rat    68 LEHRKEYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCKDAIQQLRTEAHKEIHSQQVKEHRT 132

  Fly   127 AVLDLLVSYLHSVEQIYLDQKKYRVQHELETYRLLKLAAD---KKKIPVRPAGSNSGKLGRRQVS 188
            ||||.:..||..|.::|.:|:..||:..::..||.||..:   |:|.|
  Rat   133 AVLDFVEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPHTKRKEP----------------- 180

  Fly   189 NDDSEATKSSSQANGNHDESADNDWNNDAWGDWDEDEEGDEVDDHDGEKGKEANQANQHKPRTRK 253
                 |::.||     |:.|.|:             ||            |.|.:....||....
  Rat   181 -----ASEKSS-----HNASQDS-------------EE------------KPAAEDLPEKPLAES 210

  Fly   254 RSKANRSDLNNSSSKMALDEELQQQQEADDDDPLSAEDVQLFEAENVHIYNFLQGVSEEVEQIEK 318
            :                  .||....:...:|.||.|::|:||.||..:...:..:.:||.|||.
  Rat   211 Q------------------PELGTWGDGKGEDELSPEEIQMFEQENQRLIGEMNSLFDEVRQIEG 257

  Fly   319 NVVDIAQLQDIFTEKVAMQQHNIDRIVSAVVGTTENVKDANEQIRQATQRNAGLRVWSLFFLLVM 383
            .||:|::||:||||||..|:..||.|...|||.|||:|:.||.||:|.:.|||.|||.||||::.
  Rat   258 KVVEISRLQEIFTEKVLQQETEIDSIHQLVVGATENIKEGNEDIREAIKNNAGFRVWILFFLVMC 322

  Fly   384 SFSLLFLDWY 393
            ||||||||||
  Rat   323 SFSLLFLDWY 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx18	NP_524485.1	Syntaxin-18_N	2..90	CDD:287468	34/91 (37%)
Syx18	NP_524485.1	SNARE_syntaxin18	306..364	CDD:277203	30/57 (53%)
Stx18	NP_001012151.1	Syntaxin-18_N	4..96	CDD:287468	34/91 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..225		20/128 (16%)
		SNARE_syntaxin18	245..303	CDD:277203	30/57 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351796
Domainoid	1	1.000	51	1.000	Domainoid score	I11322
eggNOG	1	0.900	-	-		E1_KOG3894
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9655
Inparanoid	1	1.050	173	1.000	Inparanoid score	I3996
OMA	1	1.010	-	-		QHG55795
OrthoDB	1	1.010	-	-		D1141750at2759
OrthoFinder	1	1.000	-	-		FOG0004915
OrthoInspector	1	1.000	-	-		oto98745
orthoMCL	1	0.900	-	-		OOG6_103713
Panther	1	1.100	-	-	LDO	PTHR15959
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6026
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770