Protein Alignment CG13625 and BUD13

DIOPT Version :10

• Sequence 1: NP_651272.1
• Gene: CG13625 / 42931
• FlyBaseID: FBgn0039210
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_116114.1
• Gene: BUD13 / 84811
• HGNCID: 28199
• Length: 619
• Species: Homo sapiens
• Alignment Length: 733
• Identity: 250/733 - (34%)
• Similarity: 330/733 - (45%)
• Gaps: 202/733 - (27%)

  Fly     3 MQKAKVIDQKEYLKKYLSG-------DKEKKKKKKEKKHKKNSANTK-VKIIDDD----AYENDN 55
            |..|..:.:.||||:||||       ..|..:|:::|:.|...|..| ::|:|||    |.....
Human     1 MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTK 65

  Fly    56 LEMDEDLLLGGEDAPQIVGEYIEEDPNVRSKWRNIAVKDEIKEEHEESSPATGIRIKQEPLDEEQ 120
            ||.:|:...|  |.| :|.|:::|.|            :|:|:.....|.|
Human    66 LEKEEEEDDG--DLP-VVAEFVDERP------------EEVKQMEAFRSSA-------------- 101

  Fly   121 EMWGRKATVVKVKDEFSPSRR--------SSPVRIKQEKRSSSRDLSPARSSKPAKREESPQRGR 177
                 |..::...:|..||.|        |||.|:    |..:.|.||.:.     |.::|....
Human   102 -----KWKLLGGHNEDLPSNRHFRHDTPDSSPRRV----RHGTPDPSPRKD-----RHDTPDPSP 152

  Fly   178 RRA--GSSDQSPTRRGR-DGDQSPPRQ-KHRDSDQSPPRKARNGNQSPVRKRRDSDQSPPRK--- 235
            |||  .:.|.||.|..| |.|.||||: :|..||.||||:||  :.||       |.||||:
Human   153 RRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRAR--HDSP-------DPSPPRRPQH 208

  Fly   236 RTGKASPTRRRRDS-DQSPPRR-RRSNSDQSPPRRRRDKDSTPPRRRKDSDQSPPRRRKADD--- 295
            .:..|||.|.|.|| |.||||| |..:||.|.|||..:......||...|..:...||...|
Human   209 NSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPD 273

  Fly   296 ---------------QSPVRRERK-----------------------DSDQSPPRKRR------D 316
                           ::|.|...|                       |.|.|||||::      |
Human   274 LAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGD 338

  Fly   317 NDQ----SPVRRRRDSDQSPPRRRRDDKQTPPRRRRNSDQSPPR-RPK----DVDQSPPRRKRDF 372
            ..|    ...::..|||.|.||.    ||:|..:..:||.|||| ||:    |.|.|||||
Human   339 KKQLDSKGDCQKATDSDLSSPRH----KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRR---- 395

  Fly   373 DQSPTRKRDKSPRRRHDSDQSPARNHRSRERSPPPRNRFKEERKSRWAKASPSKSASPPPTHKPK 437
                 |:|.||    .|||.||.|      ||.||..                           |
Human   396 -----RQRTKS----SDSDLSPPR------RSQPPGK---------------------------K 418

  Fly   438 STKTLDGKKAGLQDAKSLKKETDERRRQEHELFEKMSSEISGRDGDVQVRST--RRKGHRARDAA 500
            :.....|.|.||       ..||.:|.|: ||.|: ..|....:.:.|...|  |.|..|.|:..
Human   419 AAHMYSGAKTGL-------VLTDIQREQQ-ELKEQ-DQETMAFEAEFQYAETVFRDKSGRKRNLK 474

  Fly   501 NEDPAEQGRKEEHEKKKKELYDRWGKGLKQIEDHKSRLEEMVHEASKPVARYANDEDLDRHLREQ 565
            .| ..||.||.|.:.::.|||.:|||||.|....:..:|:.:.|..||:|||.:||||||.||||
Human   475 LE-RLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQ 538

  Fly   566 EHADDPMLEYMRQKRKKRDQQDNKPVMPKYEG-SFPENRFGIRPGYRWDGVDRSNGYEQRWFDKQ 629
            |...|||..::  |:.|..:..||.|.|:|.| :.|.|||.|.|||||||||||||:||:.|.:.
Human   539 EREGDPMANFI--KKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARL 601

  Fly   630 NERRAVQDEAYKYSVEDM 647
            ..::||::.|||:|||||
Human   602 ASKKAVEELAYKWSVEDM 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13625	NP_651272.1	PRK12678	124..>339	CDD:237171	89/282 (32%)
		U2AF_lg	300..>419	CDD:273727	49/156 (31%)
		Bud13	490..630	CDD:462867	69/140 (49%)
BUD13	NP_116114.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..56		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..429		123/390 (32%)
		MSCRAMM_ClfB	<136..402	CDD:468203	101/296 (34%)
		Bud13	460..602	CDD:462867	70/144 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..578		17/41 (41%)