DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13625 and Casc3

DIOPT Version :9

Sequence 1:	NP_651272.1	Gene:	CG13625 / 42931	FlyBaseID:	FBgn0039210	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_619601.2	Gene:	Casc3 / 192160	MGIID:	2179723	Length:	698	Species:	Mus musculus

Alignment Length:	575	Identity:	109/575 - (18%)
Similarity:	184/575 - (32%)	Gaps:	170/575 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DEIKEEHEESSPATGIRIKQEPLDEEQEMWGRKATVVKVKDEFSPSRRSSPVRIKQEKRSSSRDL 158
            |.:..::|.:..:.|    :|...||:                     :|.|.:|.|...:
Mouse    85 DAVLSDYESAEDSEG----EEDYSEEE---------------------NSKVELKSEANDA---- 120

  Fly   159 SPARSSKPAKREESPQ-----RGRRRAGSSDQS--PTRRGRDGDQSPPRQKHRDSDQ---SPPRK 213
              |.||...|.||.|:     .|.|::|...:|  |. ..:.|.:.|   ||.|.|:   :|...
Mouse   121 --ADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPV-ENKVGKKGP---KHLDDDEDRKNPAYI 179

  Fly   214 ARNG--NQSPVRKRRDSDQSPPRKRTGKASPTRRRRDSDQSPPRRRRSNSDQSPPRRRRD----- 271
            .|.|  .:..:|.:...::..|:.|..|......|.:.|       :...|:..|:.|::
Mouse   180 PRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHD-------KFREDEQAPKSRQELIALY 237

  Fly   272 ---------KDSTPPRR-RKDSDQSPPRRRK---ADDQSPVRRERKDSDQSPPRKRRDNDQSPVR 323
                     .|...||| ||....|.|:|..   .|..|...|.:......|||...:.:.:...
Mouse   238 GYDIRSAHNPDDIKPRRIRKPRFGSSPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNTAGTG 302

  Fly   324 RRRDSDQSPPRRRRDDKQTPPRRRRNSDQSPPRRPKDVDQSPPRRKRDFDQSPTRKRDK------ 382
            |...|..........|.:|..|....:.|...|..:.:......|.|..:|:|.|....
Mouse   303 RMSASRNYSRSGGFKDGRTSFRPVEVAGQHGGRSAETLKHEASYRSRRLEQTPVRDPSPEPDAPL 367

  Fly   383 --SPRRRHDSDQSPARNHRSRERSPPPRNR------FKEERKSRWAKASPSKSAS--PPPTHKPK 437
              ||.:...:.::||   ...:.:||..:|      :...|::|.......|:|.  |||:....
Mouse   368 LGSPEKEEVASETPA---AVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLA 429

  Fly   438 STKTLDGKKAGLQDAKSLKKETDERRRQEHELFEKMSSEISGRDGDVQVRSTRRKGHRARDAANE 502
            ||.|:              .||..                :.:.|:.:.......|...:|.|..
Mouse   430 STATV--------------PETTP----------------AAKTGNWEAPVDSTTGGLEQDVAQL 464

  Fly   503 DPAEQGRKEEHEKKKKELYDRWG---------KGLKQIEDHKSRLEEMVHEASKPVARYANDEDL 558
            :.|||.               |.         :.|:.:.:|       :|..:.|..::...|::
Mouse   465 NIAEQS---------------WSPSQPSFLQPRELRGVPNH-------IHMGAGPPPQFNRMEEM 507

  Fly   559 DRHLREQEHADDPMLEYMRQKRKKRDQQDNKPVMPKYEGSFPENRFGIRPGYRWD 613
            .             ::..|.||....:|...|..|.     |.....|..|:.:|
Mouse   508 G-------------VQSGRAKRYSSQRQRPVPEPPA-----PPVHISIMEGHYYD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13625	NP_651272.1	Bud13	490..630	CDD:286779	22/133 (17%)
Casc3	NP_619601.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..229		39/185 (21%)
		Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles. /evidence=ECO:0000250	134..280		34/156 (22%)
		Sufficient to form the EJC. /evidence=ECO:0000250	134..280		34/156 (22%)
		Btz	143..245	CDD:214991	22/112 (20%)
		Nuclear localization signal 1. /evidence=ECO:0000255	201..207		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..457		48/248 (19%)
		Nuclear localization signal 2. /evidence=ECO:0000255	251..259		5/7 (71%)
		Necessary for localization in cytoplasmic stress granules. /evidence=ECO:0000250	374..698		40/244 (16%)
		Nuclear export signal	457..466		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..533		11/69 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..698
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000