DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment REPTOR and Crebrf

DIOPT Version :9

Sequence 1:	NP_001036752.1	Gene:	REPTOR / 42930	FlyBaseID:	FBgn0039209	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_084146.1	Gene:	Crebrf / 77128	MGIID:	1924378	Length:	640	Species:	Mus musculus

Alignment Length:	743	Identity:	198/743 - (26%)
Similarity:	288/743 - (38%)	Gaps:	249/743 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 SSNGIGSGSGGYFTPDMSHSLSLNVVSEQVLLQEATTPN-------ELLYEMTPNSNAMWSDISS 262
            |.:|:....|..|   .||:.|...:....||..::.|:       |:.|:..|..|.:
Mouse     5 SVSGMDPPFGDAF---RSHTFSEQTLMSTDLLANSSDPDFMYELDREMNYQQNPRDNFL------ 60

  Fly   263 AIIHTKHEPFSLDDDYIFPNDKAEIQAADLSDLNGGDFLDVIGN--------------IEDFLPQ 313
                      ||:|            ..|:.:|.  .|.||:.|              .||....
Mouse    61 ----------SLED------------CKDIENLE--TFTDVLDNEDALTSNWEQWDTYCEDLTKY 101

  Fly   314 TAV-------TQSVNFLLSPQAQGQDALVAPPMELLQQQQQNHQQLQVGSLPQLQTLLTLSQQQQ 371
            |.:       |:.|::|      |.|...:|           :|..:|     :....||:|...
Mouse   102 TKLTSCDIWGTKEVDYL------GLDDFSSP-----------YQDEEV-----ISKTPTLAQLNS 144

  Fly   372 SNSSSTSPYEIYHSTPQKPQQQQLSASFSPGSQASQSPLTP-----------PPP---PHANRP- 421
            .:|.|.|....|..:....:|..|..|..|..:.:.....|           |..   ..|::|
Mouse   145 EDSQSVSDSLYYPDSLFSVKQNPLPPSSFPSKKITNRAAAPVCSSKTLQAEVPSSDCVQKASKPT 209

  Fly   422 -QYQMVKSRNM------------QELIKKGFPMSSPPE--RSILSQSAALSPGGSSGFGSSASGN 471
             ..|::...||            ::.:||.....:|.:  |.:||
Mouse   210 SSTQIMVKTNMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLS-------------------- 254

  Fly   472 STTTSNQTSGSAVRKSFGYQSAVENSQLSRLSSSAPTHLGLEHIWMRREP------RQHLL---- 526
                  |....|.:::..|..||...|..|         |:|....|..|      .|.||
Mouse   255 ------QVHIDAAKENTCYCGAVAKRQERR---------GVEPHQGRGTPALPFKETQELLLSPL 304

  Fly   527 ---STGSLAEAESFSSLSTGSVLSPDGIDFSQ-------------------------DDEDDNSS 563
               |.|.:|.||| .|||..:.:|    |.||                         |||||...
Mouse   305 TQDSPGLVATAES-GSLSASTSVS----DSSQKKEEHNYSLFVSDNMREQPTKYSPEDDEDDEDE 364

  Fly   564 ENSDNYDD-CSSDNGLSEDEDETRT----------------STPNH-------------LSSSK- 597
            .:.:::|: ..|::.|||:|:|...                |.|.:             :||.|
Mouse   365 FDDEDHDEGFGSEHELSENEEEEEEEEDYEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKR 429

  Fly   598 GKERFFWQYNVQAKGPKGKRLVFQSKLEDPHVLNEVTDPVFSPTCSVRGIKVYKHSG-------- 654
            ||.|:||:|:.|....:.:|::      .|...|..|.|          ..:|:.:|
Mouse   430 GKRRYFWEYSEQLTPSQQERIL------RPSEWNRDTLP----------SNMYQKNGLHHGKYAV 478

  Fly   655 -KARKGDGNDLTPNARKLHNIGKELDKLSRTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKK 718
             |:|:.|..|||||.:||..||.||.||::.|:|:|||||||...||:|||||||||||||||||
Mouse   479 KKSRRTDVEDLTPNPKKLLQIGNELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKK 543

  Fly   719 KAQHEANKIKLFGLEIEHKRLMNGIAELKQALVVKHRTKNLGESTEEVDQQIARIYATASSGIRI 783
            |||:||||:||:||..|:..|:..|..:||.:|  :|.:|..|..|....|...|....:.|:.:
Mouse   544 KAQYEANKVKLWGLNTEYDNLLFVINSIKQDIV--NRVQNPREEREPSMGQKLEILIKDTLGLPV 606

  Fly   784 AGGSTDFVNKVLENMRGGMPNGGLEELR 811
            ||.:::|||:||.....|.|.|||..||
Mouse   607 AGQTSEFVNQVLGKTAEGNPTGGLVGLR 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REPTOR	NP_001036752.1	coiled coil	701..756	CDD:269871	34/54 (63%)
REPTOR	NP_001036752.1	bZIP_AUREO-like	701..756	CDD:269871	34/54 (63%)
Crebrf	NP_084146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..414		27/110 (25%)
		Basic motif. /evidence=ECO:0000250	524..533		7/8 (88%)
		bZIP_AUREO-like	526..>564	CDD:269871	29/37 (78%)
		Leucine-zipper. /evidence=ECO:0000250	534..541		6/6 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KUC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008011
OrthoInspector	1	1.000	-	-		oto94364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21552
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8520
SonicParanoid	1	1.000	-	-		X5970
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.920