DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment REPTOR and crebrf

DIOPT Version :9

Sequence 1:	NP_001036752.1	Gene:	REPTOR / 42930	FlyBaseID:	FBgn0039209	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_002936755.1	Gene:	crebrf / 100490775	XenbaseID:	XB-GENE-988760	Length:	680	Species:	Xenopus tropicalis

Alignment Length:	746	Identity:	182/746 - (24%)
Similarity:	291/746 - (39%)	Gaps:	179/746 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 QQSHLALG-ELSDFGLDALDAASLSPTLLQDVSLSAVSPLSTTLYNGNTSGAGSSNGIGSGSGGY 216
            |:.:|.|. |...|.:.....:.:.|. ..|...|...|..|.:         |::.:.:.|...
Frog    21 QRKYLGLSPENLGFEMPQPSVSGMDPP-FGDAFRSPTFPEQTLM---------STDLLANSSDPM 75

  Fly   217 FTPDMSHSLSLNVVSEQVLLQEATTPNELL----------------YEMTPNSNAMWSD------ 259
            |..::...|.         .|::.|.|.|:                .|.:|...:.|..
Frog    76 FMYELDQELG---------YQQSPTENFLMLEDGKDFENLESFTDVLESSPPVTSNWEQWDTYCE 131

  Fly   260 --------ISSAIIHTKHEPFSLDDDYIFPNDKAEI--QAADLSDLNGGDFLDV----------I 304
                    .|..|..||...:...||:..|....|:  :...|:.||..|...|          :
Frog   132 DLTKYTKLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVADSLYYTDSFL 196

  Fly   305 GNIEDFLPQTAVTQSVNFLLSPQAQGQDALVAPPMELLQQQQQNHQQLQVGSLPQLQTLLTLSQQ 369
            |....::|...|| :|. :.:|....:.:....|:....|:...    .|.|: |:.....:|.:
Frog   197 GTKTSYVPGKKVT-AVR-VTAPVCSSKTSHTEVPLADCSQKATK----SVASI-QMAVKTNVSCE 254

  Fly   370 QQSNSS-------STSPYEIYHSTPQKPQQQQLSASFSP------GSQASQSPLTPPPPPHANRP 421
            ::.|..       ..:..:|....|.:|....::|..:.      |:.|.:.......|| ..|.
Frog   255 EKINLHGGCKDYVKKAKVKISSVLPCRPTTTMVAADAAKENTCFCGALAKKQEKAIGEPP-IGRK 318

  Fly   422 QYQMVKSRNMQELIKKGFPMSSPPERSILSQSAALSPG-GSSGFGSSAS---------GNSTTTS 476
            .|.::..:..|:|.        .|..::::    :.|| |::..|:|.|         ..|...|
Frog   319 NYGILPFKETQKLF--------CPAPALIT----IGPGDGNTSAGASVSDPSQKKEEHNYSLFVS 371

  Fly   477 NQTSGSAVRKSFGYQSAVENSQLSRLSSSAPTH---LGLEHIWMRREPRQHLLSTGSLAEAESFS 538
            ...:...|:.....|...|..:.:.|...  .|   .|.||.....|..:         |.|.
Frog   372 EGLTEPTVKSEISQQQEEEEEEEAELDEE--DHDEGFGSEHELSENEEEE---------EEEE-- 423

  Fly   539 SLSTGSVLSPDGIDFSQDDEDDNSSENSDNYDDCSSDNGLSEDEDETRTSTPNHLSSSKGKERFF 603
                         :..:::|:::..::.|:..|..|:.|...|..|.........|..:||.|:|
Frog   424 -------------EEEEEEEEEDYEDDKDDISDTFSEPGYENDSVEDLKGITAISSRKRGKRRYF 475

  Fly   604 WQYNVQAKGPKGKRLVFQSKLED---PHVLNEVTDPVFSPTCSVRGIKVYKHSG---------KA 656
            |:|:.|         :..|:.|.   |...|..|.|          ..:|:.:|         |:
Frog   476 WEYSEQ---------LLPSQQEGTLRPSEWNRDTLP----------SNMYQKNGLHHGKYTVKKS 521

  Fly   657 RKGDGNDLTPNARKLHNIGKELDKLSRTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKKKAQ 721
            |:.|..|||||.|||..||.||.||::.|:|:|||||||...||:||||||||||||||||||||
Frog   522 RRTDVEDLTPNPRKLLQIGGELRKLNKVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQ 586

  Fly   722 HEANKIKLFGLEIEHKRLMNGIAELKQALV------VKHRTKNLGESTEEVDQQIARIYATASSG 780
            :||||:||:||..|:..|:..|..:||.::      .:..:.::|:..:      |.|..|.  |
Frog   587 YEANKVKLWGLNTEYDNLLFVINSIKQEIMNRIQIPCEEWSASMGQKLD------AMIKDTI--G 643

  Fly   781 IRIAGGSTDFVNKVLENMRGGMPNGGLEELR 811
            ..:||.:::|||:|||....|...|||..||
Frog   644 SPVAGQTSEFVNQVLEKTSDGDATGGLVGLR 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REPTOR	NP_001036752.1	coiled coil	701..756	CDD:269871	33/60 (55%)
REPTOR	NP_001036752.1	bZIP_AUREO-like	701..756	CDD:269871	33/60 (55%)
crebrf	XP_002936755.1	bZIP_AUREO-like	566..>604	CDD:269871	29/37 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008011
OrthoInspector	1	1.000	-	-		oto104575
Panther	1	1.100	-	-	LDO	PTHR21552
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8520
SonicParanoid	1	1.000	-	-		X5970
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.130