DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment REPTOR and crebrf

DIOPT Version :9

Sequence 1:	NP_001036752.1	Gene:	REPTOR / 42930	FlyBaseID:	FBgn0039209	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005170343.1	Gene:	crebrf / 100149876	ZFINID:	ZDB-GENE-120203-3	Length:	717	Species:	Danio rerio

Alignment Length:	784	Identity:	197/784 - (25%)
Similarity:	312/784 - (39%)	Gaps:	180/784 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 PSMTHQQNQLQQQQQQQHHNQQQQLQQSHLALGELSDFGLDALDAASLSPTL----------LQD 182
            |.:..:..:|:|::.|:...|                 |.:.|.:|...|::          .|:
Zfish     8 PEIDDKIGRLRQRRCQKSFRQ-----------------GTEDLCSAMPQPSISGMDPPFGDAFQN 55

  Fly   183 VSLSAVSPLSTTLYNGNTSGAGSSNGIGSGSGGYFTPDMSHSLSLNVVSEQVLLQEATTPNEL-- 245
            .|.:..:..||.|.      |.||:           ||..:.|..::...|....:..|..:.
Zfish    56 CSFADQALTSTDLL------ANSSD-----------PDFMYELDRDMTCRQSPRGDIFTVGDCKD 103

  Fly   246 ---------LYEMTP--NSN-----AMWSDI-------SSAIIHTKHEPFSLDDDYIFPNDKAEI 287
                     |.:..|  |||     ..|.|:       |..|..||...|...||:..|....|:
Zfish   104 LDTMDHLPELVDSDPACNSNFEQWDTYWEDLTKYTRLTSCDIWGTKEVDFLGLDDFSSPYQDEEV 168

  Fly   288 --QAADLSDLNGGDFLDV----------IGNIEDFLPQTAVTQSVNFLLSPQAQGQDALVAPPME 340
              :...|:.||..|...|          :|..:...|...:.:..|...:| :.|..:...|..:
Zfish   169 ISRTPTLAQLNSEDSQPVCDTLYHPDLLVGQKQLLFPTPTMAKKTNRFSNP-STGASSSRNPLPD 232

  Fly   341 LLQQQQQNHQQLQVGSLPQLQTLLTLSQQQQSNSSSTS-----------PYEIYHSTPQKP---- 390
            ..:..|:       .:.|...:..|:::.|....|.||           ..::..|.|:||
Zfish   233 FAEGSQK-------ATWPVPSSTDTMAKAQIHGPSKTSTELLENTDYVRKAKVCFSVPRKPLVES 290

  Fly   391 QQQQLSASFSPGSQASQSPLTPPPPPHANRPQYQMVKSRNMQELIKKGFPMSSPPERSILSQSAA 455
            ..|.:|.|.|...|.|.:.|....|        .::.:.|....|.        .|:.:......
Zfish   291 SAQPVSISSSTPIQESTASLVSEDP--------AVITAANTASSIS--------CEKRVAIPKRE 339

  Fly   456 LSPGGSSGFGS-----------SASGNSTTTSNQTSGSAVRKSFGYQSAVENSQL----SRLSSS 505
            ::.|.:...|:           ||:|:.|..:....||....:...:....|..|    :||:..
Zfish   340 VTSGPAPEVGTLRAVPHKLHFPSATGSETLLTMSALGSDASAADKKKEEEHNYSLFLTRARLAGK 404

  Fly   506 APTHL------------GLEHIWMRREPRQHLLSTGSLAEAESFSSLSTGSVLSPDGIDFSQDDE 558
            ....:            ..|......|.:...|........|.|.|   ...||.:..:..::|:
Zfish   405 VTADIEEEEEEEEEEVDDEEEEEEEEEEKAEELDLDDEDHDEGFGS---EHELSENDEEEEEEDD 466

  Fly   559 DDNSSENSDNYDDCSSDNGLSED-EDETRTSTPNHLSSSKGKERFFWQYNVQAKGPKGKRLVFQS 622
            :|...:..|...|..|:.|...| .|:.:..|.. :|..:||.|:||:|:.|....|.:|::..|
Zfish   467 EDYEGDKDDYASDAFSEPGCDTDMVDDVKGLTAG-ISRKRGKRRYFWEYSEQIIPFKQERMLKPS 530

  Fly   623 KLEDPHVLNEVTDPVFSPTCSVRGIKVYKHSG-----KARKGDGNDLTPNARKLHNIGKELDKLS 682
            :.:        .|.:.|......|:    |.|     |:|:.|..|||||.|||..||.||.||:
Zfish   531 EWD--------RDTLPSNMYQKNGL----HHGKYTLKKSRRTDVEDLTPNPRKLLQIGNELRKLN 583

  Fly   683 RTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKKKAQHEANKIKLFGLEIEHKRLMNGIAELK 747
            :.|:|:|||||||...||:||||||||||||||||||||:||||:||:||..|:.||:..|..:|
Zfish   584 KVISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLGTEYDRLLFVINAIK 648

  Fly   748 QALVVKHRTKNLGES-----TEEVDQQIARIYATASSGIRIAGGSTDFVNKVLENMRGGMPNGGL 807
            :.:|  ::.:::.:.     ||::|:.|........    :|..::||||::|||...|.|.|||
Zfish   649 EEIV--NKVQDISQDKTTSMTEKLDKLIEDTLVEPP----VASQTSDFVNQILENTGKGDPTGGL 707

  Fly   808 EELR 811
            ..||
Zfish   708 VGLR 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REPTOR	NP_001036752.1	coiled coil	701..756	CDD:269871	34/54 (63%)
REPTOR	NP_001036752.1	bZIP_AUREO-like	701..756	CDD:269871	34/54 (63%)
crebrf	XP_005170343.1	bZIP_AUREO-like	602..>640	CDD:269871	29/37 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008011
OrthoInspector	1	1.000	-	-		oto40668
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5970
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030