Protein Alignment MAP3K9 and KIN4

DIOPT Version :9

• Sequence 1: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Sequence 2: NP_014876.1
• Gene: KIN4 / 854408
• SGDID: S000005759
• Length: 800
• Species: Saccharomyces cerevisiae
• Alignment Length: 1038
• Identity: 219/1038 - (21%)
• Similarity: 358/1038 - (34%)
• Gaps: 339/1038 - (32%)

Human   106 FPSNYVTPRSAFSSRCQPGGEDPSCYPPI---QLLEIDFAELTLEEIIGIGGFGKVYRAFW---- 163
            :..|.||.|...|.:     .:.....||   |.....|....:...:|.|.|||| :..|
Yeast    10 YGGNVVTDRDRHSLQ-----RNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKV-KLGWTKAS 68

Human   164 ----IGDEVAVKAARHDP-DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFA 223
                :..:||:|..|.|. .:|..:.|: :.:|......|.|||||.|..|......:.:|:||.
Yeast    69 SSNEVPKQVAIKLIRRDTIKKDADKEIK-IYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFV 132

Human   224 RGGPLNRVLSGK-RIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSN 287
            .||...:.:..| |:..........|:..|:||:|.:.:|   |||||..| |:|.|.||
Yeast   133 SGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLV---HRDLKLEN-LLLDKHEN----- 188

Human   288 KILKITDFGLAREWHRTTKM--SAAGTYAWMAPEVIRASMF--SKGSDVWSYGVLLWELLTGEVP 348
              |.|||||...|:....::  ::.|:..:.|||::.::..  ::.:||||.||:|:.:|.|.:|
Yeast   189 --LVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLP 251

Human   349 F-------RGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWN----PDPHSRPSFTNILDQ 402
            :       .| |.:|..|     |.....|...||....:..|...    |:|..|.:
Yeast   252 WDDDHENPTG-DDIARLY-----KYITQTPLKFPEYITPIPRDLLRRILVPNPRRRIN------- 303

Human   403 LTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRR 467
            |.||:...:.: |.::|..:|.|:                    |:|.|.:...:..|:.::.|.
Yeast   304 LQTIKRHVWLK-PHEAFLSIQPNY--------------------WDEHLQKERPKPPNKGDVGRH 347

Human   468 REQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDF-QHKFTVQ 531
                                        .........:.|||    |.|.:.:.|.. ||:.:.|
Yeast   348 ----------------------------STYSSSASSYSKSR----DRNSLIIESTLEQHRMSPQ 380

Human   532 ASPTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNTQGHLSPALSSH--------- 587
            .:             :|.|||||.....:.:..:|.:.:. ..|..|..:.|...:
Yeast   381 LA-------------TSRPASPTFSTGSKVVLNDTKNDMK-ESNINGERTSASCRYTRDSKGNGQ 431

Human   588 -RLVQACSIHNFCHLSSTMCIYMHILTPGESSKTWGRSSVVPKEEGEEEEK-------------- 637
             ::.|..:.|:......|....: :..||  |.|..|:...|..:..|..|
Yeast   432 TQIEQVSARHSSRGNKHTSVAGL-VTIPG--SPTTARTRNAPSSKLTEHVKDSSQTSFTQEEFHR 493

Human   638 ----RAPKKKGR--TWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQ 696
                ..|:.:.|  ::.|| |.:....:.....|..:..:||..|.::.|   :.|.::.|..|.
Yeast   494 IGNYHVPRSRPRPTSYYPG-LSRNTADNSLADIPVNKLGSNGRLTDAKDP---VPLNAIHDTNKA 554

Human   697 WSSSAPNLVKGPRSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYL 761
            ..|:                 .|:|.:                  ||||.:     :.||...:.
Yeast   555 TISN-----------------NSIMLL------------------SEGPAA-----KTSPVDYHY 579

Human   762 CIPFPRGE--DGDGPSS---DGIHEEPT--------PVNS----ATSTPQLT--PTNSLKRGGAH 807
            .|    |:  .||.|.:   |.|:::.|        |..|    :|||..:|  ||||...
Yeast   580 AI----GDLNHGDKPITEVIDKINKDLTHKAAENGFPRESIDPESTSTILVTKEPTNSTDE---- 636

Human   808 HRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSP 872
                                  |.:|:   ||                 |.:...|::...|:..
Yeast   637 ----------------------DHVES---QL-----------------ENVGHSSNKSDASSDK 659

Human   873 PSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPC 937
            .|:|:::|:.           .:.:||  .|..|.:||.:.|.:          |...|||:|
Yeast   660 DSKKIYEKKR-----------FSFMSL--YSSLNGSRSTVESRT----------SKGNAPPVS-- 699

Human   938 THNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPS 1002
                         .|:|:.....:::.: |..||    |..||....|:..:.......|  :||
Yeast   700 -------------SRNPSGQSNRSNIKI-TQQQP----RNLSDRVPNPDKKINDNRIRDN--APS 744

Human  1003 PGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDS---------TLERPKTLEFLPR 1056
                    .:.|.:||...|..    |...|.|..|..:.|         |....|.|.|..|
Yeast   745 --------YAESENPGRSVRAS----VMVSTLREENRSELSNEGNNVEAQTSTARKVLNFFKR 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	2/6 (33%)
		STKc_MLK1	137..406	CDD:271047	82/293 (28%)
		TyrKc	144..403	CDD:197581	80/283 (28%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	83/294 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910