DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K9 and BCK1

DIOPT Version :9

Sequence 1:	XP_011535090.1	Gene:	MAP3K9 / 4293	HGNCID:	6861	Length:	1166	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	334	Identity:	87/334 - (26%)
Similarity:	150/334 - (44%)	Gaps:	57/334 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   148 EIIGIGGFGKVYRAFWI--GDEVAVKAAR----HDPDEDISQTIENVRQEAKLFAMLKHPNIIAL 206
            |:||.|.||.||....:  |:.:|||...    ...:|.|..|:|.:|.|......|.|.||:..
Yeast  1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQY 1243

Human   207 RGVCLKEPNLCLVMEFARGGPLNRVLS--GKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDL 269
            .|...|.....|.:|:..||.:..::.  | |....::.:...|:.:|:.|||.:.   |:|||:
Yeast  1244 LGFENKNNIYSLFLEYVAGGSVGSLIRMYG-RFDEPLIKHLTTQVLKGLAYLHSKG---ILHRDM 1304

Human   270 KSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKMSAAGTYAWMAPEVIRASM-FSKGS 330
            |:.|:|:.|        :.|.||:|||::|   :.:..:.|:..||..|||||::.... :|...
Yeast  1305 KADNLLLDQ--------DGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKV 1361

Human   331 DVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP-STCP---EPFAKLMEDCWNPDPH 391
            |:||.|.::.|:..|:.|:..::.:|..:.:..:|.|.||| .|.|   :.....::.|:..:|.
Yeast  1362 DIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPE 1426

Human   392 SRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTW---EEELTR 453
            .||:...:|                          .|...|:.:....|...|..:   .::|..
Yeast  1427 KRPTANELL--------------------------SHPFSEVNETFNFKSTRLAKFIKSNDKLNS 1465

Human   454 AALQQKNQE 462
            :.|:..:||
Yeast  1466 SKLRITSQE 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992
		STKc_MLK1	137..406	CDD:271047	79/273 (29%)
		TyrKc	144..403	CDD:197581	79/270 (29%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	80/298 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910