Protein Alignment MAP3K9 and slpr

DIOPT Version :9

• Sequence 1: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Sequence 2: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 376/1173 - (32%)
• Similarity: 516/1173 - (43%)
• Gaps: 329/1173 - (28%)

Human    37 EEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQ 101
            |:....||.|.|        |||:::|:|.||||||||.|::|.|||.||:||||.|||||::..
  Fly    36 EQVETQVGDGSL--------WTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGD 92

Human   102 RVGIFPSNYVTPRSAFSSRCQPGGEDP------SCYPPIQLLEIDFAELTLEEIIGIGGFGKVYR 160
            :||:||.::||            .|||      |....||..||::.||.::|:||.|||.||:|
  Fly    93 KVGVFPKDFVT------------DEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHR 145

Human   161 AFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG 225
            .::.|:|||:|.|....::|:.:..:||.||||||..|||.||.||||||| ...||||||:|||
  Fly   146 GYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARG 209

Human   226 GPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKIL 290
            |.|||:|:|| ||||:|||||:||||||||||:||.:.||||||||||:||.:.:|...|..|.|
  Fly   210 GSLNRILAGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTL 273

Human   291 KITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGL 355
            ||||||||||.:.|.:||||||||||.||||..|.:||.|||||||||||||:|||.|::|.|.|
  Fly   274 KITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPL 338

Human   356 AVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH 420
            :||||||:|.|.||||.||||.:..||:.||..|||.||.|..||.||.:|..|.|...|::|||
  Fly   339 SVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFH 403

Human   421 CLQDNWKHEIQEMFDQLRAKEK-------ELRTWEEELTRAALQQKNQEELLRRREQELAEREID 478
            .:|:.|:.||..:...||.|||       |||..||:|.|...:|:.:..||:.|||.|.|||..
  Fly   404 YMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERV 468

Human   479 ILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLI 543
            ::||||.::       :|...|||.|..|....|    :||||:.|:|..|.            :
  Fly   469 LIERELVML-------QPVPSKRKHKKGKKNKPL----QISLPTGFRHTITA------------V 510

Human   544 NSRSSPPASPTIIPRLRAIQCETVSQISWGQNTQGHLSPALSSHRLVQACSIHNFCHLSSTMCIY 608
            ..::..|.                             ||:.|..|:|
  Fly   511 RDKAEQPG-----------------------------SPSFSGLRIV------------------ 528

Human   609 MHILTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELA------SGDEGSPQR 667
              .||.|.                          ||:||||.|:.|:|.:      ||  |.|:
  Fly   529 --ALTDGH--------------------------KGKTWGPSTMHQRERSLLPSQLSG--GQPE- 562

Human   668 REKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVK-------------------------- 706
                    .|:::           ..:..:|.|||||.|
  Fly   563 --------WPAQT-----------STHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSG 608

Human   707 ---GPRSSPAL-PGFTSLME-------------MALLAASWVVPIDIEEDEDSEGPGSGESRLQ- 753
               |..::|.| ||...::.             ...:..:.....:...:.::....:..::|.
  Fly   609 GAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNN 673

Human   754 -------------HSPSQSYLCIPFPRGEDGDGPSSDG--------------------IHEEPTP 785
                         :..||....|....|.:....|:..                    :..:|.|
  Fly   674 ISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPP 738

Human   786 VNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAV-LAATG--LGFDLLEAGKCQLLPLEEPEP 847
            :...|.....|.|.:...|..|..:...:....||| |...|  ||.......|...|......|
  Fly   739 LYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHP 803

Human   848 PAREEKKRREGLFQRSSRPRRSTSPPS----------RKLFKKEEPMLLLGDPSASLTLLSLSSI 902
            ||.....        .:.|.:.|.|..          |.:.||                :|::|.
  Fly   804 PANGSNS--------FALPNQLTLPSEDNNTYDHAFYRDVIKK----------------MSMASS 844

Human   903 SECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE----RFKRDPNQSLTPTHV 963
            ...||      ..|.::.:|...         :|.|.....:....    ||:|:.:.|..|.|.
  Fly   845 ERVNS------KSSGDLTMYNSS---------TPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHC 894

Human   964 TLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPS----PGAGMLKTPSPSRDPGEFPRLP 1024
            ..|         |...:|..:.|..:|:...:::..:..    |.:.|.:..:.||
  Fly   895 FFT---------RQEEEGEAEDEDAVAAEVDTADADADDECQVPASQMRQNSTTSR--------- 941

Human  1025 DPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTE 1089
            ..:|.|          |..:.|.|   :|:..||.:|..........:|.:..||.||:.|||:.
  Fly   942 KSSVTF----------QSVSFEEP---DFVATPRTTARSDLYTSSASISFATYRSASPSLSSSST 993

Human  1090 TPS 1092
            |.|
  Fly   994 TAS 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	34/56 (61%)
		STKc_MLK1	137..406	CDD:271047	171/268 (64%)
		TyrKc	144..403	CDD:197581	166/258 (64%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	36/76 (47%)
		TyrKc	129..386	CDD:197581	166/258 (64%)
		STKc_MLK	134..389	CDD:270963	166/256 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1091
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm42198
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4635
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800