DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K9 and byr1

DIOPT Version :9

Sequence 1:	XP_011535090.1	Gene:	MAP3K9 / 4293	HGNCID:	6861	Length:	1166	Species:	Homo sapiens
Sequence 2:	NP_593026.1	Gene:	byr1 / 2542137	PomBaseID:	SPAC1D4.13	Length:	340	Species:	Schizosaccharomyces pombe

Alignment Length:	332	Identity:	84/332 - (25%)
Similarity:	146/332 - (43%)	Gaps:	50/332 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    81 VLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELT 145
            ||:.::.|...:.....:|......|.||.    .||..:|......|:     .:.::|.:.|.
pombe    12 VLNPNASVKSSDNDHKEELINNQKSFESNV----EAFMEQCAHMNRRPA-----WISDLDNSSLE 67

Human   146 LEEIIGIGGFGKV-----------YRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLK 199
            :...:|.|..|.|           .:..::|.:              |:..:.:.:|..:....:
pombe    68 VVRHLGEGNGGAVSLVKHRNIFMARKTVYVGSD--------------SKLQKQILRELGVLHHCR 118

Human   200 HPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIARGMNYLHDEAIVP 263
            .|.|:...|....:.|:.|.||:...|.|:.:| .|..||.|||......:.:|:.||::  ::.
pombe   119 SPYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLYN--VLH 181

Human   264 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSK 328
            |||||||.||:::..:.|        :|:.|||::.|...:...:..||..:|:||.||...::.
pombe   182 IIHRDLKPSNVVVNSRGE--------IKLCDFGVSGELVNSVAQTFVGTSTYMSPERIRGGKYTV 238

Human   329 GSDVWSYGVLLWELLTGEVP--FRGID---GLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNP 388
            .||:||.|:.:.||.|.|:|  |..||   |:.......:.:....:||:.||.....::.|.:.
pombe   239 KSDIWSLGISIIELATQELPWSFSNIDDSIGILDLLHCIVQEEPPRLPSSFPEDLRLFVDACLHK 303

Human   389 DPHSRPS 395
            ||..|.|
pombe   304 DPTLRAS 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	7/31 (23%)
		STKc_MLK1	137..406	CDD:271047	73/276 (26%)
		TyrKc	144..403	CDD:197581	72/269 (27%)
byr1	NP_593026.1	PKc_Byr1_like	60..334	CDD:270792	73/275 (27%)
byr1	NP_593026.1	Pkinase	66..320	CDD:278497	72/269 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910