Protein Alignment MAP3K9 and mlk-1

DIOPT Version :10

• Sequence 1: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Sequence 2: NP_001300151.1
• Gene: mlk-1 / 178895
• WormBaseID: WBGene00003374
• Length: 1059
• Species: Caenorhabditis elegans
• Alignment Length: 1158
• Identity: 276/1158 - (23%)
• Similarity: 443/1158 - (38%)
• Gaps: 321/1158 - (27%)

Human    57 WTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNY----------- 110
            :.|.:||||..:|||.|.||.::.:::.:   :.::||:.|:||.:||:|||||
 Worm    74 FVASYEYEAQKDDELNLPLGAIITLVTVE---TNEDGWYRGELNGKVGLFPSNYAREVTYKDNLV 135

Human   111 ----------VTPRSAFSSRCQPG-GEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWI 164
                      |..|:.  |.||.| |...:.:.         .::.:::.:..|..|:.     :
 Worm   136 EFKQDEIMLPVAVRTL--SDCQIGHGATATVFK---------MDIKIKKELQNGRMGEA-----V 184

Human   165 GDEVAVKAA-----RHDPD--EDISQT---IENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLV 219
            ||:  :|||     ||..:  .|:..|   :|.:::||.|...|.|.||:.|.|:||::|...|:
 Worm   185 GDQ--MKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLL 247

Human   220 MEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKV 280
            :|...|..|..|.    |...||..:|::||.|:|.||.||..:..|   |||||:.|:|:.::|
 Worm   248 LELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYV---HRDLKADNVLVKEEV 309

Human   281 -----------------ENGDLSNKILKITDFGLAREWHR-TTKMSAAGTYAWMAPEVIRASMFS 327
                             .........|||||||:.|:... ..:.|.||||||:|||..:...:|
 Worm   310 CLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGTYAWLAPEAFKEGTWS 374

Human   328 KGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHS 392
            :.||||||||:||||||.|.|::|.....:|:.:|.....|.|..:||:.:.|||:||||.:|:.
 Worm   375 EASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNF 439

Human   393 RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQ 457
            ||.|:.:     .|....:.:..||: |..:...|..::|::.:..|
 Worm   440 RPKFSTL-----AISFKQYAKEFKDT-HLQRAPSKMAVKELYSECFA------------------ 480

Human   458 QKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPS 522
            .|.:|| ..:|..:|.....||..:..:.|       .|..|.|:.|..|.  |..|   |:.|:
 Worm   481 DKTKEE-FEKRFHDLYAGSGDINRKNRHSI-------APETKARRLKHHKP--KKAD---ITGPT 532

Human   523 DFQHKFTVQAS------------------PTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQ 569
            :.:|..:||..                  |.:::|:|.: |.|||             ....:|.
 Worm   533 EVKHILSVQKDDKNFRVKTYDQSSTGGTLPRLNERQSTL-SLSSP-------------DLFHISN 583

Human   570 ISWGQNTQGHLSPALS----------SHRLVQACSIHNFCHLSSTMCIYMHI--LTPGES----- 617
            :..|.||.||.:..:|          .||:.::..:......|:|.....:.  :.|..|
 Worm   584 LISGSNTVGHSAHRISRKNAIRHKKNQHRMFESPVVSPTMDDSNTFSTIDNADEVDPNHSKESKK 648

Human   618 ----SKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPS 678
                |:.|.:.....::..|:.::||......:....|.....|.:   |...|...|.||
 Worm   649 GGTLSRAWAKLPWNKRDSKEDHDERAVAGSISSRSSSTTSSNRLIT---GQTTRGASAAGL---- 706

Human   679 ESPHFHLGLK----SLVDGYKQWSSSAPNLVKGPRSSPA--LPGFTSLMEMALLAASWVVPIDIE 737
                ..:|.:    |..||::.     ||..|..:.||:  .|..|:......:.       |:|
 Worm   707 ----LEIGARSRAQSTADGWED-----PNTTKKHKVSPSDKRPVKTTNQTERYVK-------DLE 755

Human   738 EDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHE-EPTPVNSATSTPQLTPTNSL 801
            :|....     .::|..:..:|.|....|...:    |.|.|:. .|.|::|..:|     .||.
 Worm   756 KDTPLR-----PAQLPPTHRKSALDQTIPASPN----SPDSINNFHPMPLSSRRTT-----ANSS 806

Human   802 KRGGAHHRRCEVALLGCGAVLAATGLG------FDLLEAGKCQLLPLEEPEPPAREEKKRREGLF 860
            ..|..    |..||     |..:.|.|      |.|.:.     :|| .||.|...:
 Worm   807 SDGAP----CYDAL-----VSHSYGAGHGHKNHFGLSDT-----IPL-FPEEPTHYD-------- 848

Human   861 QRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDS--------D 917
               ..|.|......|.:..:.      ||...:   :|..:.......||:.:|..        |
 Worm   849 ---MGPGRPFGTNGRAIVNQG------GDYYGN---ISGQNYEGFGHGRSINQSTQYYPVGGGCD 901

Human   918 EIV------VYEMPVSPVEAPPLSP---CTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSS 973
            :.:      |.:..|..|...|.|.   |....:.|.:..:.|::.|....|     ..|.:..|
 Worm   902 DYIPIVQKTVIKPTVGEVGNSPYSENIRCATRNVQNPQYIQCKKNQNPRRIP-----ALPMKIQS 961

Human   974 HRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWN 1038
            .....:.|     .:...|....||:..|..:..|..|         |.:|.|   .||.
 Worm   962 ESNLVTSG-----MVFTPRDEQLNGIGNSLSSLSLNEP---------PDIPAP---LPPV----- 1004

Human  1039 TQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETP 1091
                           :..|.|::         .:|||:..|.||....:...|
 Worm  1005 ---------------VTYPIPAS---------LISPSNRVSMSPPTRMAPVLP 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	24/76 (32%)
		STKc_MLK1	137..406	CDD:271047	103/300 (34%)
mlk-1	NP_001300151.1	SH3	75..124	CDD:473055	21/51 (41%)
		Protein Kinases, catalytic domain	156..446	CDD:473864	105/308 (34%)