DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and TCB2

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_014312.1	Gene:	TCB2 / 855637	SGDID:	S000005031	Length:	1178	Species:	Saccharomyces cerevisiae

Alignment Length:	1167	Identity:	229/1167 - (19%)
Similarity:	383/1167 - (32%)	Gaps:	408/1167 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDNSPSVPLAEFTIPPDPTETEPFVPLVEVKKMNESPVVTPTTPTGNGTPPTQTTNGNSIVATK 65
            ||.||......:.:..|.         :.|..|:....||....|..:..    .|||.|||..|
Yeast     1 MSPNSSKTRTDQISSMPG---------INEATKVESKNVVKDAVPIKSEV----ETNGTSIVREK 52

  Fly    66 S-------------------VSDD------------NSIFSVFYTLGK-----KVAIVGSI--YL 92
            .                   .|:|            |.:...||  |.     .:.|:..:  ::
Yeast    53 QDPSYVGWKQVGGWEEKDELTSEDLLVDVNKDTFLGNLLPDKFY--GDWYHEVAILIIAGLCSFV 115

  Fly    93 VGYMGWSVAWLIAPVILSVARDQLAKTSEKK-----RDIAKASALASEKDVILARIDELPAWVYF 152
            :||..:|:|   :.:|:.:....|.:||.||     ||:|       :|:..:.:|..
Yeast   116 LGYFKFSLA---SVLIVMLTTGMLYRTSSKKYRESLRDLA-------QKEQTVEKITS------- 163

  Fly   153 PDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVA--------------LALANYKMHGFRFD 203
             |.|..||||..|.:.||            .|||:|:              :|:..: :.....|
Yeast   164 -DYESVEWLNTFLDKYWP------------IIEPSVSQQIVDGTNTALSENVAIPKF-IKAIWLD 214

  Fly   204 RIILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYA----SDCD-------------INFYLGGM- 250
            :..||..||||..:|.: :|...:.::||:.|.:.    ||.|             :...:.||
Yeast   215 QFTLGVKPPRIDAIKTF-QNTKSDVVVMDVCLSFTPHDMSDLDAKQCRNYVNSNVVLKAKIFGMD 278

  Fly   251 -KGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDF------NLVGVIDFMDMPGLSD 308
             ...:.|.....:||...: |:.::|||..:.|..|..|.:||      |.|...:.:.:|||..
Yeast   279 IPVSVADIFFQVFVRFRFQ-LMTTLPLVETINIQLLEVPEVDFISRLLGNSVFNWEILAIPGLMR 342

  Fly   309 LLRRIIVEQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLG--KG 371
            |::::..:.:..|::.|..|.:::.:.:|...|    |.|:|.|.|..|..|.|    ::|  |.
Yeast   343 LIQKMAFKYLSPVLLPPFSLQLNIPQLLSKTGL----PIGVLEIKVKNAHGLRK----LVGMIKK 399

  Fly   372 KSDPYAIINV-GAQEFKTQIIDNNVNPKW---------------------------DYWCEACIF 408
            ..|||....: |....||::..|:.||.|                           |......||
Yeast   400 TVDPYLTFELSGKIVGKTKVFKNSANPVWNESIYILLQSFTDPLTIAVYDKRETLSDKKMGTVIF 464

  Fly   409 TT----IGHY--------------IGFSLWDY---------------DQTMPGVQS--------- 431
            ..    ..||              :|...:|.               ::.:|.:.:
Yeast   465 NLNKLHANHYHKNEKVHFLRNSKPVGELTFDLRFFPTIEPKKLLNGDEEPLPDMNTGITKITIRE 529

  Fly   432 ----DDVLGRASI---------------------------DIASVI--------------KKGVV 451
                |::..:..:                           |..||:              :.|.|
Yeast   530 LKGLDELSDKKFVFAELYVNAELVMTTKKEKRTAHLKWNSDYYSVVTDRRKTICRFVLKDQSGKV 594

  Fly   452 DS------------------WLTLEDAKHGLLHVRLQWYKLTADPNDLQQILLETQLLRVTSMSS 498
            .|                  |:.|.:.| |.|.|...|..:..|.. |:.:...|.:
Yeast   595 ISSSVQPLNHLIDRTEVNKEWIPLRNGK-GELKVTTYWRPVDIDLG-LKSVGYTTPI-------- 649

  Fly   499 AVLSVFIDSARHLKQARSSSKPDPYLVCSVN-KQKQQTAMIMRDDSPVWEQGFTFLVSNP----- 557
            .:|.|||:.|.:|:...|..|..||...||| ..:.:|...:...:|:|.|.....|::|
Yeast   650 GMLRVFINKAENLRNPDSLGKISPYAKVSVNGVARGRTNERIETLNPIWNQSIYVSVTSPLQKVS 714

  Fly   558 -----------DNE--SLNIK---IYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQPFQLQKSGPE 606
                       |:.  ||||:   || .|..:|  :||..:....:..|:        :.|.|.:
Yeast   715 IDCFGIDTNGDDHNLGSLNIQTQNIY-HKDNDD--KYTIFIDNAPRTGNL--------IGKKGVK 768

  Fly   607 SKL--YMS-------LSLRILKP-GEIDKDSDALEQVAALTRSSSVKTPDVAAVSPPAFK----- 656
            ..:  |:|       |||...|. .||::..|.||:..:.....::...:...:....|:
Yeast   769 GTVTYYLSFYPVVPVLSLEEAKEVDEINEKKDKLEKQKSTLDDKNISKEEKERIKKEEFRLTEKY 833

  Fly   657 ESQASSKRLSAESPISEEDPVAATKI------SPAMSAST------------------------S 691
            :..:...:|..:..:.....|....:      .|.:...|                        |
Yeast   834 DMYSYKMKLDLDELLQYNAGVLGVTVLGGELPQPGLYVQTFFDSCGYAAITSAKNAIRTIKTGWS 898

  Fly   692 SEKPISELATSVLTHRF---PDSTSSPG---EHGLGRMQL-----------------SIRYSAQR 733
            .:..|.||..||.|.|.   .|:..:..   |..:..::|                 |.:...|.
Yeast   899 GDFMIKELEWSVTTFRVTKTKDANKAENFICEVNIPTIELVRNCYYKPSVLNLIGKKSAKLLVQV 963

  Fly   734 QKLDVTIHKIQ-----------KIPLRDPSNI--------PDPYVKLYLLPGRTKESKRKTSVIK 779
            ....||..::.           ||..:...|:        .||||:.:|....|... .||:|.|
Yeast   964 SWFPVTATELPQSDLITNSGDLKITAKSAENLIGVNKNGYSDPYVEFFLNEKSTSPF-FKTAVQK 1027

  Fly   780 DNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLN 841
            ...||.::.|  ..|.::......|.:.|...:...|..|  ||...:||...:..:.|..|
Yeast  1028 KTLNPTWNES--KTIEVSNRVNDYLTINVKDYESTNSNRS--IGKAVVPLSTIDPESDTTFN 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	52/216 (24%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	40/257 (16%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	32/126 (25%)
		C2C_KIAA1228	719..847	CDD:175996	32/159 (20%)
TCB2	NP_014312.1	COG5038	4..1178	CDD:227371	227/1164 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344866
Domainoid	1	1.000	49	1.000	Domainoid score	I2938
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46963
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X61
TreeFam	0	0.000	Not matched by this tool.
	9	8.720