Protein Alignment Esyt2 and TCB3

DIOPT Version :9

• Sequence 1: NP_001247287.1
• Gene: Esyt2 / 42929
• FlyBaseID: FBgn0266758
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_013639.1
• Gene: TCB3 / 854903
• SGDID: S000004537
• Length: 1545
• Species: Saccharomyces cerevisiae
• Alignment Length: 1015
• Identity: 204/1015 - (20%)
• Similarity: 364/1015 - (35%)
• Gaps: 286/1015 - (28%)

  Fly     7 SVPL-----AEFTIPP-------DPTETEPFVPLVEVKKMNESPV-----------------VTP 42
            :|||     .||...|       |.:.|:|.| |.::.|::|..:                 |..
Yeast   115 AVPLEGLRPKEFRSAPSRKPNKFDTSITKPGV-LDDLGKLDEKDIKEKFHLDSDDKLFPWQNVGE 178

  Fly    43 TTPTGNGTPPTQTTNGNSIVATKSVSDDNSIFSVFYTLGKKVAIVGSIY---LVGYMGWSVAWLI 104
            ...:|.|:|.|:.:.     ..|:...:| .::.:|.  ....::|:.:   |..|:|:| .|.:
Yeast   179 FHASGKGSPNTKMSR-----VIKAYILEN-FYNDWYC--NIATVLGTCFFSWLFAYIGFS-WWSM 234

  Fly   105 APVILSVARDQLAKTSEKKRDIAKASALASEKDVILARIDELPAWVYFPDVERCEWLNKILKQVW 169
            ..:.|..|....|:.:...|:|.......:.::.:..|            ||...|||..|.:.|
Yeast   235 IFIFLGTATVYNAEYTRFNRNIRDDLKRVTVEETLSDR------------VESTTWLNSFLSKFW 287

  Fly   170 PNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIMDLD 234
            ..........||:.:.|.:|.....|.:.....|...||:..|.|.|:|.|.| ..:|.:.||..
Yeast   288 VIYMPVLSQQVKDNVNPQLAGVAPGYGIDALAIDEFTLGSKAPTIKGIKSYTK-TGKNTVEMDWS 351

  Fly   235 L-FYASDCD----------IN--FYLGGMKGG----------IKDFQIHGWVRVVMKPLIRSMPL 276
            . |..||..          ||  ..||...|.          ::|..:.|.:|:.:: ..::.|.
Yeast   352 FAFTPSDVSDMTATEAREKINPKISLGVTLGKSFVSKTMPILVEDINVAGKMRIKVE-FGKAFPN 415

  Fly   277 VGGLQIFFLNNPNIDFNLVGV------IDFMD-MPGLSDLLRRIIVEQIGNVMVLPNKLPISLSE 334
            :..:.:..|..|.|||.|..:      :|.|. :|||...::.||...||.::..||.|.|:: |
Yeast   416 IKIVSLQLLEPPLIDFALKPIGGDTLGLDVMSFLPGLKSFVKNIINSNIGPMLFPPNHLDINV-E 479

  Fly   335 EVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLGKGKSDPYAIINV-----GA-QEFKTQIIDN 393
            ::.|...|  |..|:|.:.:..|..|...|...   ...|||.::..     |. :|.:|.|..|
Yeast   480 DIMAAQSK--EAIGVLAVTIASADSLKGSDFIT---NTVDPYIVMTTEDAVPGTDEEVRTSIKSN 539

  Fly   394 NVNPKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSW---L 455
            ..||:|:. .:..:..|:...:....:|::.    |:.|.|:|...:|:|.:::..|:|:.   |
Yeast   540 VKNPRWNE-TKYLLLNTLEQKLNLKCFDFND----VRKDTVIGDLQLDLADLLQNPVLDNQTAEL 599

  Fly   456 TLEDAKHGLLHVRLQWYKLTADPNDLQQI------------------------------------ 484
            .......|:||..|.|:.:..|.::.:.:
Yeast   600 RSGTKSKGILHYSLHWFPVKEDKSEEKAVERAEAKAKGKKEDENEDTTEKEEDENEESSQTDVGI 664

  Fly   485 ----LLETQLLRVTSMSSAVLS----VFIDSARHLKQARSSSKPDPYLVCSVNKQKQQTAMIMRD 541
                |.:.:.|..||..:..||    :|||..: :|..|:                     :.|.
Yeast   665 AKITLQKVKYLDTTSSMTGSLSPCAELFIDGQK-VKSYRT---------------------LRRI 707

  Fly   542 DSPVWEQGFTFLVSNPDNESLNIKIYDQKTGND--IGQYTYTLSTLLKQFNMEVIQQPFQLQKSG 604
            :.|.|.:....||.:..|....:||:|.:....  |.:|:.:|..:     |..:....:..|..
Yeast   708 NEPSWNETIEVLVPSKSNSKFVLKIFDDRMNGKALICEYSSSLDDI-----MTTLDTAQEFVKGS 767

  Fly   605 PESKLYMSLSLRILKPGEIDKDSDALEQVAALTRSSSVKTPDVAAVSPPAFKESQASSKRLSAES 669
            |:..:|:.:|.:            ::|...|...::||..| :..:             :|..:.
Yeast   768 PQGDIYLDVSWK------------SIEMTGAFAAANSVSEP-IGCI-------------KLDVKD 806

  Fly   670 PISEEDPVAATKISPAMSAS------------TSSEKPISELAT--------SVLTHRFPDSTSS 714
            .|.:.|......:.|..:.|            :.::.||.:.:|        .:||..|.|....
Yeast   807 AIIKGDLSGVGDVDPYYTVSLNRRVLYKSIYHSDTDHPIFDNSTYVPIFSPNQILTLEFHDYQKI 871

  Fly   715 PGEHGLGRMQL-----------SIRYSAQRQKLDVTIHKIQKIPLRD-----------------P 751
            ..:..:|.:|:           |.:|.....|     .:|.|:.|:|                 |
Yeast   872 GKDRFIGSVQIPTSNVFKKDPKSGKYVGNNGK-----EEISKLKLKDHEHKVTESIVNVSTTFIP 931

  Fly   752 SNI---PDPYVKLYLLPGRTKESKRKTSVIKD------NCNP----------VYDASFEYLISIA 797
            .|:   |:..|.:..|....||.|:|....::      ..||          .:|:..:.:...|
Yeast   932 INLVYSPEELVNVEKLEKELKEKKKKFEATQEENEQEMEKNPKEWEVAEIEDPFDSDEKKINRKA 996

  Fly   798 ELRQTELEVTVCTQKGFLSGG------SPIIGMLKIPLDD 831
            :|...||   :..:.|.||..      ||....|:|..||
Yeast   997 KLSLNEL---IKQKSGILSMQILEGTLSPSSAYLEILADD 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	55/207 (27%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	31/131 (24%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	21/110 (19%)
		C2C_KIAA1228	719..847	CDD:175996	34/166 (20%)
TCB3	NP_013639.1	COG5038	44..1335	CDD:227371	204/1015 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I2938
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46963
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X61
TreeFam	0	0.000	Not matched by this tool.
	8	7.790