DRSC/TRiP Functional Genomics Resources

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Protein Alignment Esyt2 and ESYT3

DIOPT Version :9

Sequence 1:NP_001247287.1 Gene:Esyt2 / 42929 FlyBaseID:FBgn0266758 Length:853 Species:Drosophila melanogaster
Sequence 2:NP_001309760.1 Gene:ESYT3 / 83850 HGNCID:24295 Length:886 Species:Homo sapiens


Alignment Length:917 Identity:254/917 - (27%)
Similarity:426/917 - (46%) Gaps:144/917 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 ESPVVTPTTPTGNGTPPTQTTNGNSIVATKSVSDDNSIFSV---FYTLGKKVAIVGSIYLVGYMG 97
            |.| ..|..|:..|   .|.|.|..:..:..:..:...|.|   ||        :|.:||.||:|
Human     4 EEP-CAPGAPSALG---AQRTPGPELRLSSQLLPELCTFVVRVLFY--------LGPVYLAGYLG 56

  Fly    98 WSVAWLIAPVILSV--ARDQLAKTSEKKRDIAKASALASEKDVILARI--DELPAWVYFPDVERC 158
            .|:.||:...:|.:  .|::..|..   |..|....|.:|::.|...:  ..||||::||||||.
Human    57 LSITWLLLGALLWMWWRRNRRGKLG---RLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERV 118

  Fly   159 EWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKN 223
            ||.|||:.|.||..:....:..:|.:||.:  ...:..:..|.|.::..|...||:.|||.:...
Human   119 EWANKIISQTWPYLSMIMESKFREKLEPKI--REKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNT 181

  Fly   224 VDRNEIIMDLDLFYASDCDINFYLGGMKGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNP 288
            .:|..:.:||.:.|..||:|:..|..::.|:...|:.|.:||:::||:...|.||.:.:|||..|
Human   182 CNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTVFFLQKP 246

  Fly   289 NIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIH 353
            ::..|..|:.:.:|.||::|:...::.:.|...:||||::.:.:.:.:....|:.|.|.|::|:|
Human   247 HLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLRFPLPCGVIRVH 311

  Fly   354 VVEAKDLMKKDISVLG-KGKSDPYAIINVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYIGF 417
            ::||:.|.:|| :.|| :|||||||.:::|.|.|:::.|..|:||.|:...|..::...|..:..
Human   312 LLEAEQLAQKD-NFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEV 375

  Fly   418 SLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPNDLQ 482
            .|:|.|     ...||.||...|.:..|:...|||.|..|.|...|.||:||:|..|..|    |
Human   376 DLYDED-----TDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTD----Q 431

  Fly   483 QILLETQLLRVTSMSSAVLSVFIDSARHLKQ------------------ARSSSKPDP--YLVCS 527
            ::|.|..    ..:|:|:|.||::||.:|.:                  ||:....||  |:..|
Human   432 EVLTEDH----GGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLS 492

  Fly   528 VNKQKQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNME 592
            |.|:...:.....:..|||.|.|:|.|.|...|.|::|:.|......:|.....|..:|...:: 
Human   493 VGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECALGMLEVPLCQILPYADL- 556

  Fly   593 VIQQPFQLQKSGPESKLYMSLSLRILK------------PGEIDKDSDALEQVAA---------- 635
            .::|.|||..||.:|.:.|.|.||.|:            |..:.|....:::||.          
Human   557 TLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQE 621

  Fly   636 ------------------LTRSSSVKTPDVAAVSPPAFKES------QASSKRL----------- 665
                              ::||::..|......:.|..:|:      :.|:||.           
Human   622 EGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPA 686

  Fly   666 ---------SAESPISEEDPVAA---------TKISPAMSASTSSEKPISELATSVLTHRFPDST 712
                     .:..||....|:..         .:::|:||:..|......:||...|.....|..
Human   687 TIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGGDLR 751

  Fly   713 SSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKI-PLRDPSNIPDPYVKLYLLPGRTKESKRKTS 776
                ...||.:||::||...|:.|.|.|:..:.: |.  .|:..||||::||||.|....::|||
Human   752 ----RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPC--TSSGADPYVRVYLLPERKWACRKKTS 810

  Fly   777 VIKDNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLN 841
            |.:....|::|.:||:.:.:.|:::..|:|.|...:...|.....:|.:.|.|...::.  .|.:
Human   811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLI--KGFS 873

  Fly   842 SWFDLQP 848
            .|::|.|
Human   874 QWYELTP 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Esyt2NP_001247287.1 SMP_LBD 154..332 CDD:293652 56/177 (32%)
C2A_Synaptotagmin-like 348..471 CDD:175990 47/123 (38%)
C2B_Synaptotagmin-like 500..605 CDD:176015 34/124 (27%)
C2C_KIAA1228 719..847 CDD:175996 39/128 (30%)
ESYT3NP_001309760.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 6/20 (30%)
SMP_LBD 114..290 CDD:293652 56/177 (32%)
C2A_C2C_Synaptotagmin_like 306..424 CDD:176037 47/123 (38%)
C2B_Synaptotagmin-like 445..568 CDD:176015 33/123 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..673 6/59 (10%)
C2C_KIAA1228 755..879 CDD:175996 39/127 (31%)
Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250 801..808 1/6 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152754
Domainoid 1 1.000 157 1.000 Domainoid score I4142
eggNOG 1 0.900 - - E1_COG5038
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 463 1.000 Inparanoid score I1556
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48596
OrthoDB 1 1.010 - - D196935at33208
OrthoFinder 1 1.000 - - FOG0000510
OrthoInspector 1 1.000 - - otm42273
orthoMCL 1 0.900 - - OOG6_100476
Panther 1 1.100 - - LDO PTHR45761
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2311
SonicParanoid 1 1.000 - - X61
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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