DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and SYTD

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_196671.2	Gene:	SYTD / 830978	AraportID:	AT5G11100	Length:	569	Species:	Arabidopsis thaliana

Alignment Length:	581	Identity:	157/581 - (27%)
Similarity:	269/581 - (46%)	Gaps:	99/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 YLVG-YMGWSVAWLIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVILARI----DELPAWV 150
            :|.| ::|.:|::   .::::.||....: |.::.|:||..|..:...|..:|.    |..|:||
plant     3 FLFGLFIGIAVSF---GLVVAFARYSSVR-STRRADLAKTIAAFARMTVQDSRKLLPGDFYPSWV 63

  Fly   151 YFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANY---KMHGFRFDRIILGTIPP 212
            .|...::..|||..|:::||..|..|..|:|.::||    .|..|   .:...:|.:..|||:.|
plant    64 VFSQRQKLNWLNLELEKIWPYVNEAASELIKSSVEP----VLEQYTPAMLASLKFSKFTLGTVAP 124

  Fly   213 RIGGVKIYDKNVDRNEIIMDLDLFYASD----CDINFYLG-GMKGGIKDFQIHGWVRVVMKPLIR 272
            :..||.|.:.....|.|.|:|::.:..:    .|:...|| .:...:|:....|..|::.|||:.
plant   125 QFTGVSILESESGPNGITMELEMQWDGNPKIVLDVKTLLGVSLPIEVKNIGFTGVFRLIFKPLVD 189

  Fly   273 SMPLVGGLQIFFLNNPNIDFNL--VGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNK--LPISLS 333
            ..|..|.|.........:||.|  :|. :...:||:||.:...|.:.|.:.:..|.:  :|| |.
plant   190 EFPCFGALSYSLREKKGLDFTLKVIGG-ELTSIPGISDAIEETIRDAIEDSITWPVRKIIPI-LP 252

  Fly   334 EEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLGKGKSDPYAIINVGA---QEFKTQIIDNNV 395
            .:.|.:.||   |.|.|.:.||:||||..||:.    ||||||||:.:..   :..||:.|.|::
plant   253 GDYSDLELK---PVGKLDVKVVQAKDLANKDMI----GKSDPYAIVFIRPLPDRTKKTKTISNSL 310

  Fly   396 NPKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTL--- 457
            ||.|:...|..:......::...::|.:    ||.|..::|.|.:.:..::...|.|.||.|
plant   311 NPIWNEHFEFIVEDVSTQHLTVRVFDDE----GVGSSQLIGAAQVPLNELVPGKVKDIWLKLVKD 371

  Fly   458 ----EDAKH-GLLHVRLQW----------------YKLT------------ADPNDLQQILLETQ 489
                .|.|: |.:.:.|.:                |.||            :|..|::::
plant   372 LEIQRDTKNRGQVQLELLYCPLGKEGGLKNPFNPDYSLTILEKVLKPESEDSDATDMKKL----- 431

  Fly   490 LLRVTSMSS-----AVLSVFIDSARHLKQARSSSKPDPYLVCSVNKQ--KQQTAMIMRDDSPVWE 547
               |||...     .||||.:.:|..|.......|.|.::|.::.|.  |.:|.::....:|||.
plant   432 ---VTSKKKDVIVRGVLSVTVVAAEDLPAVDFMGKADAFVVITLKKSETKSKTRVVPDSLNPVWN 493

  Fly   548 QGFTFLVSNPDNESLNIKIYD-QKTGND-IGQYTYTLSTLLKQFNMEVIQQPFQLQ--KSG 604
            |.|.|:|.:..::.|.::::| .|.|.| ||:...||:.::.:..   .|:.|:|.  |||
plant   494 QTFDFVVEDALHDLLTLEVWDHDKFGKDKIGRVIMTLTRVMLEGE---FQEWFELDGAKSG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	51/189 (27%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	41/133 (31%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	34/111 (31%)
		C2C_KIAA1228	719..847	CDD:175996
SYTD	NP_196671.2	SMP_LBD	69..251	CDD:293652	51/187 (27%)
		C2	264..368	CDD:278593	36/111 (32%)
		C2	443..545	CDD:278593	30/104 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I2321
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I1645
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D52746at2759
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm3072
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770