DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and ESYT2

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_024302614.1	Gene:	ESYT2 / 57488	HGNCID:	22211	Length:	868	Species:	Homo sapiens

Alignment Length:	819	Identity:	277/819 - (33%)
Similarity:	445/819 - (54%)	Gaps:	101/819 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LGKKVAIVGSIYLVGYMGWSVAW-LIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVIL--- 140
            |.:..|::..:|.:||:|.|.:| |:|..:|:..|   .....|...:.:|.||..:::.::
Human    88 LARSFALLLPVYALGYLGLSFSWVLLALALLAWCR---RSRGLKALRLCRALALLEDEERVVRLG 149

  Fly   141 ARIDELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRI 205
            .|..:|||||:|||.||.|||||.:|.:||....|...|.:|||||  |:..||..:..|.|.::
Human   150 VRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEP--AVRGANTHLSTFSFTKV 212

  Fly   206 ILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLGG--MKGGIKDFQIHGWVRVVMK 268
            .:|..|.||.|||:|.:|||:.:||:||.:.:..:|:|:..:..  .:.|:|..||||.:||:::
Human   213 DVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILE 277

  Fly   269 PLIRSMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLS 333
            |||..|||||.|.||||..|.::.|..|:.:.:|:|||:.|...||::.|.|.:||||::.:.|.
Human   278 PLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLV 342

  Fly   334 EEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAIINVGAQEFKTQIIDNNVN 396
            .||....|:.|.|:|:||||.:||:||..||..:.|  |||||||.||.||.|.|::::|..|::
Human   343 SEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLS 407

  Fly   397 PKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAK 461
            |||:...||.::...|..:...|:|.|.     ..||.||...||:..|.|:.::|.|.||::..
Human   408 PKWNEVYEALVYEHPGQELEIELFDEDP-----DKDDFLGSLMIDLIEVEKERLLDEWFTLDEVP 467

  Fly   462 HGLLHVRLQWYKLTADPNDLQQILLETQLLRVTS---MSSAVLSVFIDSARHLKQARSSSKPDPY 523
            .|.||:||:|..|..:.::|.::|.:.:..:..:   :|||:|.:::||||:|        |..|
Human   468 KGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNL--------PIRY 524

  Fly   524 LVCSVNKQKQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQ 588
                            :.:.||||:.|||.:.||..:.|.:::.|::....:|.....||.||..
Human   525 ----------------KTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTS 573

  Fly   589 FNMEVIQQPFQLQKSGPESKLYMSLSLRILKPGEIDKDSD-------ALEQVAALTRSSSVK--- 643
            .:|.|.|: |||..|||.|.:.|.::||:|...:.::..|       ....|:...|.:|:|
Human   574 EDMTVSQR-FQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHM 637

  Fly   644 --------------TPDVAAVSPPAFKE---------------SQASSKRLSAESPISEEDPVAA 679
                          ||.:.....|..:|               .::||..|::...||.::|
Human   638 SGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEP--- 699

  Fly   680 TKISPAMSASTSSEKPISELATSVLTHRFP--DSTSSPGEHGLGRMQLSIRYSAQRQKLDVTIHK 742
               :|::::..|  .||   ||..|..|..  ::.::.|:..||::||:||:|:||.||.|.:|.
Human   700 ---TPSIASDIS--LPI---ATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHA 756

  Fly   743 IQKIPLRDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLISIAELRQTELEVT 807
            .:.: :....:..||||::||||.:.:..:|||.|.|...|||:|.||::.:|:.|:::..|:|.
Human   757 CRNL-IAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVA 820

  Fly   808 VCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDL 846
            |....||||....::|.:.:.|...|:.  .|...|:||
Human   821 VKNSGGFLSKDKGLLGKVLVALASEELA--KGWTQWYDL 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	77/179 (43%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	53/124 (43%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	31/104 (30%)
		C2C_KIAA1228	719..847	CDD:175996	48/128 (38%)
ESYT2	XP_024302614.1	SMP_LBD	163..342	CDD:293652	77/180 (43%)
		C2A_C2C_Synaptotagmin_like	357..477	CDD:176037	53/124 (43%)
		C2B_Synaptotagmin-like	509..589	CDD:176015	31/104 (30%)
		C2C_KIAA1228	733..858	CDD:175996	48/128 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152753
Domainoid	1	1.000	157	1.000	Domainoid score	I4142
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32699
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48596
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm42273
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	1	1.100	-	-	O	PTHR45761
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2311
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800