DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and esyt1b

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_699731.6	Gene:	esyt1b / 571083	ZFINID:	ZDB-GENE-040724-209	Length:	1827	Species:	Danio rerio

Alignment Length:	850	Identity:	231/850 - (27%)
Similarity:	397/850 - (46%)	Gaps:	159/850 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VEVKKMNESPVVTPTTPTGNGTPPTQTTNGNSIVATKSVSDDNSIFSVFYTLGKKVAIVGSIYLV 93
            |:.:..|:|..:|        .|...:::|...|....:.|..:|   .:|.||.:..:..:||.
Zfish     4 VDSETTNDSQKIT--------EPAQDSSSGEMDVPKTKLFDAKAI---LWTFGKCLTALLPVYLA 57

  Fly    94 GYMGWSVAWLIAPVILSVARDQLAKTSEKK-----------RDIAKASALASEKDVILARIDELP 147
            ||...|.:.::..:::........:..|.:           ::...:.:..|::|        ||
Zfish    58 GYYRMSTSLVVFGMMVYAGWKHTREAKEARLRSAIQLVNDEQEYVSSKSFRSKRD--------LP 114

  Fly   148 AWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRIILGTIPP 212
            :||.|||||:.|||||::.|.||....:...|:.|||.|  |:..::..:....|.:|..|..|.
Zfish   115 SWVNFPDVEKVEWLNKVIHQAWPFIGQYLEKLLTETIAP--AIRGSSAHLQTLSFTKIDFGGKPM 177

  Fly   213 RIGGVKIYDKNVDRNEIIMDLDLFYASDCDINF----YLGGMKGGIKDFQIHGWVRVVMKPLIRS 273
            ::.|||.:.:| |:.:|::|:.:.|..|.:||.    |.  .|.|:|..|:||.:||:::|||..
Zfish   178 KVVGVKAHTEN-DKGQILLDVYISYVGDVEINVEVKRYF--CKAGVKGIQLHGMMRVILEPLISD 239

  Fly   274 MPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLSEEVSA 338
            :|:||.:.:||:..|.:..|..|:.:.:|:|||:.:...:|::.|.:.:||||:|.:.|..::..
Zfish   240 VPIVGAVTMFFIQRPKLTINWTGLTNLLDIPGLNVMSDTMIMDAIASFLVLPNRLTVPLVADLPV 304

  Fly   339 VALKMPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAIINVGAQEFKTQIIDNNVNPKWDY 401
            ..|:.|.|.|::|||::||.:|..||..|.|  .|.||||||:.||.|.||:..:||.::|||..
Zfish   305 AQLRCPLPRGVVRIHLLEADNLAAKDNYVKGVMAGMSDPYAIVRVGPQTFKSHHLDNTLSPKWGE 369

  Fly   402 WCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAKHGLLH 466
            ..|..:....|..:...::|.|.     ..||.|||..:|:..|.|..:||.|..|:|.:.|.:|
Zfish   370 VYEVVVHEVPGQELEVEVFDKDP-----DHDDFLGRTKLDLGIVKKSKIVDEWFNLKDTQTGRVH 429

  Fly   467 VRLQWYKLTADPNDLQQILLETQLLRVTSM-----SSAVLSVFIDSARHLKQARSSSKPDPYLVC 526
            ::|:|..|......|:::|...:  .|.|.     |:|:|:|::|.|..|...:.:..|:|.:..
Zfish   430 LKLEWLTLETHTERLKEVLKRNE--SVVSKAAEPPSAAILAVYLDKAEALPMKKGNKDPNPIVQI 492

  Fly   527 SVNKQKQQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNM 591
            ||....:.:.:.....:|.||..|||.:.:|:|:.:::::.|......:|:.:...|.||...::
Zfish   493 SVQNATRDSRICWNTVNPQWEDAFTFFIRDPNNQDISVQVKDNDRVQLLGKMSIPASRLLSHPDL 557

  Fly   592 EVIQQPFQLQKSGPESKLYMSLSLRILKPGEIDKDSDALEQVAALTRSSSVKTPDVAAVSPPAFK 656
            . :.:.:.|:.|||:|:::::..||:|...|           ||:|.|
Zfish   558 S-MDEWYNLENSGPKSRIHINTVLRVLWLDE-----------AAVTAS----------------- 593

  Fly   657 ESQASSKRLSAESPISEEDPVAATKISPAMSASTSSEK--PISELATSVLTHRFPDSTSSPGEHG 719
                    |.:..|:|:               |:..||  |.|..||                .|
Zfish   594 --------LLSSGPLSK---------------SSRPEKTTPHSSFAT----------------EG 619

  Fly   720 LGRMQLSIRYSAQRQKLDVTIHKIQKIPLRDPSNI--------PDPYVKLYLLPGRTKESKRKTS 776
            |.|                 ||.::...|....|:        .|||||:. :.|.|    .|:.
Zfish   620 LLR-----------------IHLVEGQNLVAKDNLMGGMVKGKSDPYVKIQ-IGGET----FKSH 662

  Fly   777 VIKDNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGLN 841
            |||:|.||.::..:|  :.:.||...||.:.|..:.  :......:|.||:.|.|  |.:...:|
Zfish   663 VIKENLNPTWNEMYE--VVLTELPGQELTLEVFDKD--MDMKDDFMGRLKMSLSD--IISSQYIN 721

  Fly   842 SWFDL 846
            .||.|
Zfish   722 EWFSL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	63/181 (35%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	48/124 (39%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	24/104 (23%)
		C2C_KIAA1228	719..847	CDD:175996	36/135 (27%)
esyt1b	XP_699731.6	SMP_LBD	121..299	CDD:293652	63/182 (35%)
		C2A_C2C_Synaptotagmin_like	314..434	CDD:176037	48/124 (39%)
		C2B_Synaptotagmin-like	466..570	CDD:176015	24/104 (23%)
		C2A_C2C_Synaptotagmin_like	619..740	CDD:176037	36/135 (27%)
		C2B_Synaptotagmin-like	772..860	CDD:176015
		C2	974..1094	CDD:301316
		C2B_Synaptotagmin-like	1126..1228	CDD:176015
		C2A_C2C_Synaptotagmin_like	1409..1529	CDD:176037
		C2	1561..1663	CDD:301316
		C2C_KIAA1228	1701..1823	CDD:175996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587249
Domainoid	1	1.000	153	1.000	Domainoid score	I4241
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1672
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm24761
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	1	1.100	-	-	O	PTHR45761
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760