Protein Alignment Esyt2 and esyt3

DIOPT Version :10

• Sequence 1: NP_001247287.1
• Gene: Esyt2 / 42929
• FlyBaseID: FBgn0266758
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001011364.1
• Gene: esyt3 / 496831
• XenbaseID: XB-GENE-5746165
• Length: 889
• Species: Xenopus tropicalis
• Alignment Length: 918
• Identity: 278/918 - (30%)
• Similarity: 439/918 - (47%)
• Gaps: 126/918 - (13%)

  Fly    18 DPTETEPFVPLVEVKKMNESPVVTPTTPTGNGTPPTQTTNGNSIVATKSVSD------------- 69
            ||....|..|....||.:| |..| ..|.|.|..|.....|.     |.:.|
 Frog     5 DPGGQTPQAPQGTDKKPDE-PKAT-EKPQGAGPQPRDPPGGE-----KGLRDPPGGEKGPRDPGQ 62

  Fly    70 ---DNSIFSVFYTLG----KKVAIVGSIYLVGYMGWSVAWLIAPVILSVARDQLAKTSEKKRDIA 127
               ..::....|.||    :.|..:..:||.|..|.|..||:..:.|     .:..|..||..:|
 Frog    63 GGAGEALAEALYGLGRPVLRAVLYLFPVYLCGRFGLSPTWLLFGLFL-----WMFWTRNKKFKLA 122

  Fly   128 KASA---LASEKDVILAR---IDELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEP 186
            :..|   |...:.:.:.|   :.:|||||.||||||.|||||::.|:||....:...:.::.:||
 Frog   123 RIQAAWDLHENEKLGVTRGLYLQQLPAWVNFPDVERVEWLNKVVGQMWPYIGMYVEKMFQDKVEP 187

  Fly   187 NVALALANYKMHGFRFDRIILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLGGM- 250
            .|..:.|:.|  .|.|.::.||...|||.|||.|.||||:.|:|:||.|.|..|.:||..:..|
 Frog   188 LVRSSSAHLK--AFTFTKVHLGEKFPRINGVKSYTKNVDKREVILDLQLSYNGDVEINVEVKKMC 250

  Fly   251 KGGIKDFQIHGWVRVVMKPLIRSMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIV 315
            |.|:|..|:||.:||::.||:..:|.||.:.:||:..|::|.|..|:.:.:::||:||....:||
 Frog   251 KAGVKGVQLHGTLRVILAPLLPDLPFVGAVTMFFIQRPHLDINWTGLTNVLEIPGVSDFSDSMIV 315

  Fly   316 EQIGNVMVLPNKLPISLSEEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAI 378
            :.|.:.:||||:..:.||.:|.|..|:.|.|.|:||:|::||:||:.||..:.|  :|||||||:
 Frog   316 DMIASHLVLPNRFTVPLSSQVQAAQLRFPLPHGVLRLHLIEAEDLIPKDNYLKGIIRGKSDPYAV 380

  Fly   379 INVGAQEFKTQIIDNNVNPKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIA 443
            :.:|.|.||::.|..|:||||....|..:....|..:...|:|.|.     ..||.||...|.:.
 Frog   381 LRIGNQNFKSRTIKENLNPKWGEMYEFVVHEVPGQDLEVDLYDEDP-----DKDDFLGSLVIGLE 440

  Fly   444 SVIKKGVVDSWLTLEDAKHGLLHVRLQWYKLTADPNDLQQILLETQLLRVTSMSSAVLSVFIDSA 508
            .|::..|||.|..|.|...|.:|:||:|..|......|.:        ....:|:|:|.|::|||
 Frog   441 GVMQDRVVDEWFPLSDVPSGSVHLRLEWLSLLPKSEKLSE--------AKGGISTAMLIVYLDSA 497

  Fly   509 --------------------RHLKQARSSSKPDPYLVCSVNKQKQQTAMIMRDDSPVWEQGFTFL 553
                                ||:...::...|:.|::.||.|:..::........|||.|.|.|.
 Frog   498 SALPRNHFEYSSSEYTTRKQRHMTYTKTDKDPNSYVLMSVGKKSVKSKTCTGSTEPVWGQAFAFF 562

  Fly   554 VSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEV-IQQPFQLQKSGPESKLYMSLSLRI 617
            :.:...:.|::::.|.:....:|.....|..||.  |.|: ..|.|.|..|||.|.:.|.:.||:
 Frog   563 IQDVHMQHLHLEVKDSERQCALGMLDLPLHRLLG--NEELTADQRFPLANSGPNSTIKMKIVLRV 625

  Fly   618 -----------------LKPGEID-------------KDSDALEQVAALTRSSSVKTPDVAAVSP 652
                             ||.|.:.             |...|..|.....::.:|:.|.......
 Frog   626 LHVEAPEPESIYTGINSLKQGPVSIKRAQSQQHKSHGKSHQAHHQAHQTQQNHTVQQPKAERKES 690

  Fly   653 PAFKESQASSKRLSAESPISEEDPVAATKISPAMSASTSSEKPISELATSVLTHRF-------PD 710
            .:....||::   |:.:|...::|.:...:.   .:.|.|.||:..:|.|:|:...       |:
 Frog   691 ISTTSQQANT---SSSNPAPNQNPNSTGAVP---ESHTPSLKPLERIAPSLLSLNSIGSSVFDPN 749

  Fly   711 STSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKIPLRDPSNIPDPYVKLYLLPGRTKESKRKT 775
            ....|.|. .|.:::|:||::.|:.|.|.|:..:.: ::..||..||||::||||.|....::||
 Frog   750 DKRWPSEM-TGEVEVSVRYASLRRCLVVLINSCRNL-IQCSSNGADPYVRIYLLPDRKWSGRKKT 812

  Fly   776 SVIKDNCNPVYDASFEYLISIAELRQTELEVTVCTQKGFLSGGSPIIGMLKIPLDDAEITTQTGL 840
            ||.:...||.|:..||:|:|..|.::..|:|.|...:||.|.....:|.:.:.|...::.  .|.
 Frog   813 SVKRKTLNPQYNERFEFLVSQEEAKKRMLDVAVKNNRGFGSHERKELGKVLVDLSCDDLV--KGF 875

  Fly   841 NSWFDLQP 848
            ..||:|.|
 Frog   876 TKWFELTP 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_ESyt	156..332	CDD:439226	70/176 (40%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	49/124 (40%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	30/125 (24%)
		C2C_KIAA1228	719..847	CDD:175996	42/127 (33%)
esyt3	NP_001011364.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		16/66 (24%)
		gly_rich_SclB	<2..>79	CDD:468478	19/80 (24%)
		SMP_ESyt3	157..334	CDD:439237	71/178 (40%)
		C2A_C2C_Synaptotagmin_like	348..468	CDD:176037	49/124 (40%)
		C2B_Synaptotagmin-like	489..613	CDD:176015	30/125 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..724		11/80 (14%)
		C2C_KIAA1228	757..882	CDD:175996	42/128 (33%)
		Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membrane. /evidence=ECO:0000250	804..811		1/6 (17%)