DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Esyt2 and pla2g4aa

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_571370.1	Gene:	pla2g4aa / 30554	ZFINID:	ZDB-GENE-990415-45	Length:	741	Species:	Danio rerio

Alignment Length:	415	Identity:	83/415 - (20%)
Similarity:	152/415 - (36%)	Gaps:	116/415 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 LQQILLETQ--------LLRVTSMSSAVLSVFIDSARHLKQARSSSKPDPYLVCSV---NKQKQQ 534
            :..|::|.|        ::|..:::.......:|:            ||||:..||   .:.:::
Zfish     1 MSNIIVEHQYSHRLKLTVVRAENVTKGAFGDLLDT------------PDPYVELSVPTTPESRKR 53

  Fly   535 TAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGND--IGQYTYTLSTLLKQFNMEVIQQP 597
            |..|..|.:|.|.:.|.|::....:..|.:.:.|.....|  :|...|:||.|      :|.|..
Zfish    54 TRHINNDINPKWNETFEFILDPNQSNVLEVTLMDANYVMDETLGTAKYSLSKL------KVAQME 112

  Fly   598 FQLQKSGPESKLYMSLSLRILKPGEIDKDSDAL---EQVAALTR--------------------- 638
            ......|..:|:::.|.|.:....:: :.|..|   |::...||
Zfish   113 HVTLSIGKTTKVFLDLLLEVCASTDL-RFSMTLCDQEKLFMQTRRDRVMLSIKKLLKMENPRFLP 176

  Fly   639 SSSVKTPDVAAV-SPPAFKESQASSKRLSA--ESPISEEDPVAATKISPAMSASTSSEKPISELA 700
            ||..:.|.:|.: |...|:.....|..:.|  ||.:.:    .||.:: .:|.||       ...
Zfish   177 SSPREVPTIAILGSGGGFRAMVGFSGVMKALYESGVFD----CATYVA-GLSGST-------WYM 229

  Fly   701 TSVLTH-RFPDSTSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQKIPLR--DPSNIPDPYVKLY 762
            :.:.:| .||  ...||:.....|                 :::...||:  .|.|| :.|||..
Zfish   230 SMLYSHPEFP--AKGPGDINKELM-----------------NRVSNNPLKLLLPQNI-NRYVKAL 274

  Fly   763 LLPGRTKESKRKTSVIKDNCNPV-YDASFEYLISIAELRQTELEVTVCTQKGFLSGGS---PIIG 823
            .        |:|::     ..|| :...|..||. ..|....:.:.:.:.||.::.|.   |:..
Zfish   275 W--------KKKSA-----GQPVTFTDIFGMLIG-ETLIPGRMNIKLSSLKGKINEGQSPLPLFT 325

  Fly   824 MLKIPLDDAEITTQTGLNSWFDLQP 848
            .|.:..|.:|:.    ...|.:..|
Zfish   326 CLHVKPDVSELM----FADWVEFSP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652
		C2A_Synaptotagmin-like	348..471	CDD:175990
		C2B_Synaptotagmin-like	500..605	CDD:176015	24/109 (22%)
		C2C_KIAA1228	719..847	CDD:175996	25/133 (19%)
pla2g4aa	NP_571370.1	Phospholipid binding. /evidence=ECO:0000305	1..172		37/189 (20%)
		C2_cPLA2	13..132	CDD:176001	29/136 (21%)
		PLAc	113..658	CDD:214474	55/285 (19%)
		cPLA2_Grp-IVA	138..719	CDD:132839	51/260 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900