DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esyt2 and Esyt2

DIOPT Version :9

Sequence 1:	NP_001247287.1	Gene:	Esyt2 / 42929	FlyBaseID:	FBgn0266758	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_038968040.1	Gene:	Esyt2 / 299488	RGDID:	1565705	Length:	900	Species:	Rattus norvegicus

Alignment Length:	891	Identity:	288/891 - (32%)
Similarity:	463/891 - (51%)	Gaps:	152/891 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LGKKVAIVGSIYLVGYMGWSVAW-LIAPVILSVARDQLAKTSEKKRDIAKASALASEKDVIL--- 140
            |.:..|::..:|.:||:|.|.:| |:|..:|:..|   .....|...:.:|.||..:::..:
  Rat    40 LARSFALLLPVYALGYLGLSFSWVLLALGLLAWCR---RSRGLKASRLCRALALLEDEEQAVRLG 101

  Fly   141 ARIDELPAWVYFPDVERCEWLNKILKQVWPNANHFARTLVKETIEPNVALALANYKMHGFRFDRI 205
            .|..:|||||:|||.||.|||||.:|.:||....|...|.:|||||  |:..||..:..|.|.::
  Rat   102 VRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEP--AVRGANAHLSTFSFTKV 164

  Fly   206 ILGTIPPRIGGVKIYDKNVDRNEIIMDLDLFYASDCDINFYLGG--MKGGIKDFQIHGWVRVVMK 268
            .:|..|.|:.|||:|.:|||:.:||:||.:.:..:|:|:..:..  .:.|:|..||||.:||:::
  Rat   165 DVGHQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILE 229

  Fly   269 PLIRSMPLVGGLQIFFLNNPNIDFNLVGVIDFMDMPGLSDLLRRIIVEQIGNVMVLPNKLPISLS 333
            |||..|||||.|.||||..|.::.|..|:.:.:|:|||:.|...||::.|.|.:||||::.:.|.
  Rat   230 PLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLV 294

  Fly   334 EEVSAVALKMPEPEGILRIHVVEAKDLMKKDISVLG--KGKSDPYAIINVGAQEFKTQIIDNNVN 396
            .||....|:.|.|:|:||||.:||:||..||..:.|  |||||||.||.||.|.|:::::..|::
  Rat   295 SEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVVKENLS 359

  Fly   397 PKWDYWCEACIFTTIGHYIGFSLWDYDQTMPGVQSDDVLGRASIDIASVIKKGVVDSWLTLEDAK 461
            |||:...||.::...|..:...|:|.|.     ..||.||...||:..|.|:.::|.|.||::..
  Rat   360 PKWNEVYEALVYEHPGQELEIELFDEDP-----DKDDFLGSLMIDLIEVEKERLLDEWFTLDEVP 419

  Fly   462 HGLLHVRLQWYKLTADPNDLQQILLETQLLRVTS---MSSAVLSVFIDSAR-------------H 510
            .|.||::|:|..|..|..:|.::|.:.:..:..:   :|||:|.:::||||             :
  Rat   420 KGKLHLKLEWLTLMPDAANLDKVLADIRADKDQANDGLSSALLILYLDSARNLPSIYEGNFGCGY 484

  Fly   511 LKQARSS-------------------------------------------SKPDPYLVCSVNKQK 532
            ||:.|:|                                           |.|:|.:..||..:.
  Rat   485 LKERRASGLVFCENTTSVYRALFSNPLDFNPGVLKKSAVQRALKSGKKINSNPNPLVQMSVGHKA 549

  Fly   533 QQTAMIMRDDSPVWEQGFTFLVSNPDNESLNIKIYDQKTGNDIGQYTYTLSTLLKQFNMEVIQQP 597
            |::.:..:...||||:.|||.:.||..:.|.:::.|::....:|.....||.||...|| .|.|.
  Rat   550 QESKIRYKTSEPVWEENFTFFIHNPKRQDLEVEVKDEQHQCSLGSLRIPLSQLLASDNM-TINQR 613

  Fly   598 FQLQKSGPESKLYMSLSLRILKPGEIDKDSDALEQVAALTRSSSVKTPDVA------------AV 650
            |||..|||.|.|.|.::||:|   .::|.    |:......|:.||.|.|:            :.
  Rat   614 FQLSNSGPNSTLKMKIALRVL---HLEKQ----ERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSA 671

  Fly   651 SP-------------------PAFKE---------------SQASSKRLSAESPISEEDPVAATK 681
            ||                   ||.:|               .::||..|::.|.|:.::|
  Rat   672 SPGTGGTNTAPSTPVMGVDDKPAMEEKPQPPEASPLGQRDLGRSSSSLLASPSHIAAKEP----- 731

  Fly   682 ISPAMSASTSSEKPISELATSVLTHRFP--DSTSSPGEHGLGRMQLSIRYSAQRQKLDVTIHKIQ 744
             :|::::..|  .||   ||..|..|..  ::.::.|:..||::||:||:|:||.||.|.:|..:
  Rat   732 -TPSIASDIS--LPI---ATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCR 790

  Fly   745 KIPLRDPSNIPDPYVKLYLLPGRTKESKRKTSVIKDNCNPVYDASFEYLISIAELRQTELEVTVC 809
            .: :....:..||||::||||.:.:..:|||.|.|...|||:|.||::.:|:.|:::..|:|.|.
  Rat   791 NL-IAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVK 854

  Fly   810 TQKGFLSGGSPIIGMLKIPLDDAEITTQTGLNSWFDL-----QPEI 850
            ...||||....::|.:.:.|...|:.  .|...|:||     :|::
  Rat   855 NSGGFLSKDKGLLGKVLVALASEELA--KGWTQWYDLTEDGTRPQV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esyt2	NP_001247287.1	SMP_LBD	154..332	CDD:293652	76/179 (42%)
		C2A_Synaptotagmin-like	348..471	CDD:175990	51/124 (41%)
		C2B_Synaptotagmin-like	500..605	CDD:176015	39/160 (24%)
		C2C_KIAA1228	719..847	CDD:175996	48/132 (36%)
Esyt2	XP_038968040.1	SMP_LBD	115..294	CDD:293652	76/180 (42%)
		C2A_C2C_Synaptotagmin_like	309..429	CDD:176037	49/121 (40%)
		C2B_Synaptotagmin-like	461..621	CDD:176015	59/261 (23%)
		C2C_KIAA1228	765..890	CDD:175996	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346274
Domainoid	1	1.000	138	1.000	Domainoid score	I4714
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32699
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1715
OMA	1	1.010	-	-		QHG48596
OrthoDB	1	1.010	-	-		D196935at33208
OrthoFinder	1	1.000	-	-		FOG0000510
OrthoInspector	1	1.000	-	-		otm46424
orthoMCL	1	0.900	-	-		OOG6_100476
Panther	1	1.100	-	-	O	PTHR45761
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910